Zobrazeno 1 - 10
of 50
pro vyhledávání: '"David Plouffe"'
Autor:
Gregory LaMonte, Michelle Yi-Xiu Lim, Melanie Wree, Christin Reimer, Marie Nachon, Victoria Corey, Peter Gedeck, David Plouffe, Alan Du, Nelissa Figueroa, Bryan Yeung, Pablo Bifani, Elizabeth A. Winzeler
Publikováno v:
mBio, Vol 7, Iss 4 (2016)
ABSTRACT Mutations in the Plasmodium falciparum cyclic amine resistance locus (PfCARL) are associated with parasite resistance to the imidazolopiperazines, a potent class of novel antimalarial compounds that display both prophylactic and transmission
Externí odkaz:
https://doaj.org/article/33570c8df3e44fc5aca76e483b8c7bab
Autor:
Selina E R Bopp, Micah J Manary, A Taylor Bright, Geoffrey L Johnston, Neekesh V Dharia, Fabio L Luna, Susan McCormack, David Plouffe, Case W McNamara, John R Walker, David A Fidock, Eros Lazzerini Denchi, Elizabeth A Winzeler
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003293 (2013)
Malaria parasites elude eradication attempts both within the human host and across nations. At the individual level, parasites evade the host immune responses through antigenic variation. At the global level, parasites escape drug pressure through si
Externí odkaz:
https://doaj.org/article/8dafe0de613f4bffa311fa8d95a17f85
Autor:
Michael Delves, David Plouffe, Christian Scheurer, Stephan Meister, Sergio Wittlin, Elizabeth A Winzeler, Robert E Sinden, Didier Leroy
Publikováno v:
PLoS Medicine, Vol 9, Iss 2, p e1001169 (2012)
BackgroundMalaria remains a disease of devastating global impact, killing more than 800,000 people every year-the vast majority being children under the age of 5. While effective therapies are available, if malaria is to be eradicated a broader range
Externí odkaz:
https://doaj.org/article/eab4562c67984e28b2e94ac3e6fdc00d
Autor:
Yingyao Zhou, Vandana Ramachandran, Kota Arun Kumar, Scott Westenberger, Phillippe Refour, Bin Zhou, Fengwu Li, Jason A Young, Kaisheng Chen, David Plouffe, Kerstin Henson, Victor Nussenzweig, Jane Carlton, Joseph M Vinetz, Manoj T Duraisingh, Elizabeth A Winzeler
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1570 (2008)
A fundamental problem in systems biology and whole genome sequence analysis is how to infer functions for the many uncharacterized proteins that are identified, whether they are conserved across organisms of different phyla or are phylum-specific. Th
Externí odkaz:
https://doaj.org/article/9ff24481e65442d8b72e2de939c307a5
Autor:
Claire Kidgell, Sarah K Volkman, Johanna Daily, Justin O Borevitz, David Plouffe, Yingyao Zhou, Jeffrey R Johnson, Karine G. Le Roch, Ousmane Sarr, Omar Ndir, Soulyemane Mboup, Serge Batalov, Dyann F Wirth, Elizabeth A Winzeler
Publikováno v:
PLoS Pathogens, Vol 2, Iss 8 (2006)
Externí odkaz:
https://doaj.org/article/abf4c3ab37304e8aa510c2a2dcc35cfe
Autor:
Claire Kidgell, Sarah K Volkman, Johanna Daily, Justin O Borevitz, David Plouffe, Yingyao Zhou, Jeffrey R Johnson, Karine Le Roch, Ousmane Sarr, Omar Ndir, Soulyemane Mboup, Serge Batalov, Dyann F Wirth, Elizabeth A Winzeler
Publikováno v:
PLoS Pathogens, Vol 2, Iss 6, p e57 (2006)
Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in the development of new effective vaccines and in the
Externí odkaz:
https://doaj.org/article/ba60074bd6a54c3593f223908982d7b0
Autor:
Manu Vanaerschot, David A. Fidock, Kerstin Gagaring, Karla P. Godinez-Macias, Jaeson Calla, Yevgeniya Antonova-Koch, Case W. McNamara, Madeline R. Luth, Melanie Wree, Elizabeth A. Winzeler, Sabine Ottilie, Marisa L. Martino, Korina Eribez, David Plouffe, Alan Y. Du, Matthew Abraham
Publikováno v:
ACS Infectious Diseases
Most phenotypic screens aiming to discover new antimalarial chemotypes begin with low cost, high-throughput tests against the asexual blood stage (ABS) of the malaria parasite life cycle. Compounds active against the ABS are then sequentially tested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7959fd781960974e52a313b682449f16
https://doi.org/10.1021/acsinfecdis.9b00482
https://doi.org/10.1021/acsinfecdis.9b00482
Autor:
Michael Leven, Vicky M. Avery, Stephan Meister, Jana Held, Michael J. Delves, Sandra Duffy, Krystina Kuna, Elizabeth A. Winzeler, Benjamin Mordmüller, Thomas Kurz, Leandro A. Alves Avelar, Serena Tschan, David Plouffe
Publikováno v:
ChemMedChem. 14:501-511
A series of novel 8-aminoquinolines (8-AQs) with an aminoxyalkyl side chain were synthesized and evaluated for in vitro antiplasmodial properties against asexual blood stages, liver stages, and sexual stages of Plasmodium falciparum. 8-AQs bearing 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78defdef19417f9bc4af603611451eb1
https://doi.org/10.1002/cmdc.201800691
https://doi.org/10.1002/cmdc.201800691
Autor:
Case W. McNamara, Dyann F. Wirth, Francisco-Javier Gamo, Dionicio Siegel, Yevgeniya Antonova-Koch, Dennis E. Kyle, Korina Eribez, Cullin McLean Taggard, Maureen Ibanez, François Nosten, Yang Zhong, Sabine Ottilie, Edward Owen, Victor Chaumeau, Jeremy N. Burrows, Kaisheng Chen, Elizabeth A. Winzeler, Mélanie Rouillier, Madeline R. Luth, Christie Lincoln, Stephan Meister, Juan Carlos Jado, Tomoyo Sakata-Kato, David A. Fidock, Yingyao Zhou, Kerstin Gagaring, Manuel Llinás, Jaeson Calla, Biniam Ambachew, Matthew Abraham, Amanda K. Lukens, Amy J. Conway, Fernando Neria Serrano, Manu Vanaerschot, Andrea L. Cheung, Brice Campo, Steven P. Maher, David Plouffe
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Science (New York, N.Y.), vol 362, iss 6419
Science (New York, N.y.)
Consejería de Sanidad de la Comunidad de Madrid
Science (New York, N.Y.), vol 362, iss 6419
Science (New York, N.y.)
To discover leads for next-generation chemoprotective antimalarial drugs,we tested more than 500,000 compounds for their ability to inhibit liver-stage development of luciferase-expressing Plasmodium spp. parasites (681 compounds showed a half-maxima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276ca79aa5124b1a30513b1776aa4ace
https://doi.org/10.1126/science.aat9446
https://doi.org/10.1126/science.aat9446
Autor:
David Plouffe
A NEW YORK TIMES BESTSELLERAs seen on CBS This Morning, PBS NewsHour, The Daily Show with Trevor Noah, Pod Save America and moreA voter's playbook on making a difference in the 2020 election and beyond from the most recognized and most successful pol
