Výsledky vyhledávání - "David Philip Lowe"

Estimating alloantibody levels in highly sensitized renal allograft candidates: Using serial dilutions to demonstrate a treatment effect in clinical trials

Autor: Carrie A. Schinstock, Anat R. Tambur, David Philip Lowe, Byron H. Smith, Mark D. Stegall, Chelsea Maguire

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsREFERENCES. 21(3)

Small reductions in calculated panel-reactive antibody (cPRA) are associated with increased kidney transplantation in 100% cPRA patients. However, the high level of antibody in these patients is such that desensitization may reduce antibody but not c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c377691eb9bb2b5a8f742d8625ffd7
https://pubmed.ncbi.nlm.nih.gov/33078553

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Pregnancy-induced HLA antibodies respond more vigorously after renal transplantation than antibodies induced by prior transplantation

Autor: Sunil Daga, Robert Higgins, Lam Chin Tan, Nithya Krishnan, Habib Kashi, Pat Hart, Connie White Williams, David Philip Lowe, Christopher H.E. Imray, Simon Fletcher, Daniel Zehnder, David Briggs, M. Hathaway, For T. Lam

Publikováno v: Human Immunology. 76:546-552

Acute antibody mediated rejection after HLA-specific antibody incompatible renal transplantation is related to donor specific HLA antibody (DSA) levels. DSA levels may rise sharply after transplant, and aim of this study was to examine changes in DSA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8098824c7c1dad412d987bd5c87463f
https://doi.org/10.1016/j.humimm.2015.06.013

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Meeting report: 3rd international transplant conference: how much risk can you take?

Autor: Robert Higgins, Nithya Krishnan, Sunil Daga, David Briggs, Daniel A. Mitchell, N. A. Khovanova, David Philip Lowe

Publikováno v: International Journal of Immunogenetics. 42:59-68

The 3rd International Transplant Conference took place on 31st October and 1st November 2014 at the University of Warwick, Coventry, UK. Key focal points of the meeting were the exploration of the molecular basis of antibody–antigen interactions an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9255ebd504c713ebf4c36bf2a26c5b2e
https://doi.org/10.1111/iji.12184

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Novel data-driven stochastic model for antibody dynamics in kidney transplantation∗∗This work has been supported by EPSRC UK (EP/K02504X/1)

Autor: N. A. Khovanova, David Philip Lowe, Yan Zhang, David Briggs, Robert Higgins

Publikováno v: IFAC-PapersOnLine. 48:249-254

Falls in the serum levels of donor specific HLA antibodies (DSA) after kidney transplantation are of great clinical interest, as they are associated with resolution of rejection and good long term outcomes in patients at high risk of graft loss. A da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd818354cb9af94204a69e70dad1692d
https://doi.org/10.1016/j.ifacol.2015.10.147

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HLA incompatible combined liver–kidney transplantation: Dynamics of antibody modulation revealed by a novel approach to HLA antibody characterisation

Autor: Ahmed Hamsho, Andrew Holt, David Philip Lowe, John A. C. Buckels, Richard Borrows, Paolo Muiesan, David Briggs, Kassi Skordilis, Graham Lipkin, Geoffrey Hayden, Shazia Shabir

Publikováno v: Transplant Immunology. 30:30-33

This case report confirms the utility of simultaneous liver transplantation in allowing successful kidney transplantation in the face of preformed, high levels of DSA, which would under normal circumstances be associated with hyperacute rejection and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e504ca83024caf70d2415db3241d5a16
https://doi.org/10.1016/j.trim.2013.11.002

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Human Leukocyte Antigen-Specific Antibodies and Gamma-Interferon Stimulate Human Microvascular and Glomerular Endothelial Cells to Produce Complement Factor C4

Autor: Guerman Molostvov, David Briggs, Daniel Zehnder, Lam Chin Tan, Christopher H.E. Imray, David Philip Lowe, Nithya Krishnan, Daniel A. Mitchell, Peter W. Mathieson, Rizwan Hamer, For T. Lam, Robert Higgins, Habib Kashi, Simon C. Satchell, Simon Fletcher, Rebecca Ilyas

Publikováno v: Transplantation. 93:867-873

Background: The role of the complement system in antibody-mediated rejection has been investigated in relation to circulating complement interacting with renal microvascular endothelium, resulting in the formation of peritubular capillary C4d. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1c6e61318c693c1451e947e5420802
https://doi.org/10.1097/tp.0b013e31824b3762

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Human Leukocyte Antigen Antibody-Incompatible Renal Transplantation: Excellent Medium-Term Outcomes With Negative Cytotoxic Crossmatch

Autor: David Philip Lowe, Matthew Edey, Habib Kashi, Daniel Zehnder, Nithya Krishnan, Rizwan Hamer, Klaus Chen, M. Hathaway, Robert Higgins, C. Imray, Clare Williams, Sunil Daga, Simon Fletcher, David Briggs, Lam Chin Tan, For T. Lam

Publikováno v: Transplantation. 92:900-906

Background. Human leukocyte antigen (HLA) antibody-incompatible renal transplantation has been increasingly performed since 2000 but with few data on the medium-term outcomes. Methods. Between 2003 and 2011, 84 patients received renal transplants wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378d60b8f5423381fecdbb9781159766
https://doi.org/10.1097/tp.0b013e31822dc38d

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Cryofiltration in the Treatment of Cryoglobulinemia and HLA Antibody-Incompatible Transplantation

Autor: Nithya Krishnan, Rizwan Hamer, Simon Fletcher, Robert Higgins, Mark Lambie, Daniel Zehnder, Kath McSorley, David Briggs, David Philip Lowe, Devan Sinha

Publikováno v: Therapeutic Apheresis and Dialysis. 16:91-96

Cryofiltration is a technique in which plasma is separated from blood and chilled, leading to the formation of "cryogel", a composite of heparin, fibronectin, fibrinogen, immunoglobulins, and other proteins. This is retained by further filtration and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68c5fc9396d9839004de003ffdbf8a31
https://doi.org/10.1111/j.1744-9987.2011.01004.x

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Double Filtration Plasmapheresis in Antibody-Incompatible Kidney Transplantation

Autor: Nithya Krishnan, Rizwan Hamer, Klaus Chen, M. Hathaway, Lam Chin Tan, For T. Lam, Robert Higgins, Habib Kashi, David Philip Lowe, David Briggs, Simon Fletcher, Daniel Zehnder, Christopher H.E. Imray

Publikováno v: Therapeutic Apheresis and Dialysis. 14:392-399

Double filtration plasmapheresis (DFPP) was used in preference to plasma exchange in our program of antibody-incompatible transplantation, to treat higher volumes of plasma. Forty-two patients had 259 sessions of DFPP, 201 pre-transplant and 58 post-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89051810763e314bb0d3a259e25e70c6
https://doi.org/10.1111/j.1744-9987.2010.00821.x

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