Zobrazeno 1 - 10
of 11
pro vyhledávání: '"David Pelloso"'
Autor:
Yi Jiun Chen, Hua Chen Chang, Shivani Srivastava, John F. Toso, Hailin Feng, Zdenka Haskova, Michael J. Robertson, Zdenka Ludmila Jonak, David Pelloso, Stephen H. Trulli, Margaret N. Whitacre, Larry Voiles, David W. Lewis
Publikováno v:
Cancer Immunology, Immunotherapy. 62:1073-1082
The antitumor activity of monoclonal antibodies is mediated by effector cells, such as natural killer (NK) cells, that express Fc receptors for immunoglobulin. Efficacy of monoclonal antibodies, including the CD20 antibody rituximab, could be improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3268756781270515ee9dbaca2a5dd325
https://doi.org/10.1007/s00262-013-1403-0
https://doi.org/10.1007/s00262-013-1403-0
Autor:
Jeffrey B. Travers, Hua Chen Chang, Michael J. Robertson, Manuel De La Rosa, Kinnari Oza, Ling Han, Allysia Schwartz, Ivan P. Lupov, Ravi P. Sahu, David Pelloso, Larry Voiles
Publikováno v:
Blood. 118:6097-6106
Signal Transducer and Activator of Transcription 4 (STAT4) is a transcription factor that is activated by IL-12 signaling and promotes Th1-cell differentiation and IFN-γ production. Defective IFN-γ production because of STAT4 mRNA and protein defic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9033a588b6a6212685c4cc55767aa76f
https://doi.org/10.1182/blood-2011-03-341867
https://doi.org/10.1182/blood-2011-03-341867
Publikováno v:
Blood. 106:963-970
Production of interferon γ (IFN-γ) is critical for optimal antitumor immunotherapy in several preclinical animal models. Interleukin-12 (IL-12)–induced IFN-γ production is markedly defective after autologous stem cell transplantation. Quantitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002977c69f4922b3fff40153b1bc0ff7
https://doi.org/10.1182/blood-2005-01-0201
https://doi.org/10.1182/blood-2005-01-0201
Publikováno v:
Clinical Cancer Research. 10:1935-1942
Purpose: The purpose is to determine the immunological effects of recombinant human interleukin (rhIL)-12 therapy after autologous stem cell transplantation.Experimental Design: Twelve patients (8 non-Hodgkin’s lymphoma, 2 Hodgkin’s disease, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae163cd38e8cb8f00e2164f47999aeb5
https://doi.org/10.1158/1078-0432.ccr-03-1156
https://doi.org/10.1158/1078-0432.ccr-03-1156
Publikováno v:
Journal of Clinical Oncology. 34:e19066-e19066
Background: Iboctadekin (recombinant human IL-18) is an immunostimulatory cytokine with anti-tumor activity in preclinical animal models. Phase I clinical trials have demonstrated that IL-18 is well-tolerated as monotherapy or in combination with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba51b4d2c0c2d350170edf0c1ea63d4
https://doi.org/10.1200/jco.2016.34.15_suppl.e19066
https://doi.org/10.1200/jco.2016.34.15_suppl.e19066
Autor:
Michael J, Robertson, David, Pelloso, Rafat, Abonour, Robert A, Hromas, Robert P, Nelson, Lisa, Wood, Kenneth, Cornetta
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 8(11)
To determine the safety, maximum tolerated dose,and biological effects of recombinant human IL-12 after autologous stem cell transplantation for cancer.Twelve patients with hematological malignancies (8 non-Hodgkin's lymphoma, 2 Hodgkin's disease, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21ce881bd5baa6e64904b766d4a93c19
https://pubmed.ncbi.nlm.nih.gov/12429625
https://pubmed.ncbi.nlm.nih.gov/12429625
Autor:
Chun-Yu Tung, Sharifah Kyazike, David Lewis, Ling Han, Alexander Kolb, David Pelloso, Anthony Sinn, Karen E. Pollok, Shivani Srivastava, Michael J. Robertson, Hua-Chen Chang
Publikováno v:
Blood. 122:1042-1042
Introduction Immunostimulatory cytokines can enhance anti-tumor immunity and are part of the therapeutic armamentarium for cancer treatment. We have previously reported that chemotherapy-treated lymphoma patients have acquired deficiency of Signal Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1253a658a096e96b07adbfc57c45af
https://doi.org/10.1182/blood.v122.21.1042.1042
https://doi.org/10.1182/blood.v122.21.1042.1042
Publikováno v:
Blood. 116:2780-2780
Abstract 2780 NK cells play an important role in innate and adaptive immune responses. Most human NK cells express CD16, an Fc receptor for IgG that mediates lysis of antibody-coated target cells and costimulates interferon (IFN)-g production in resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5842f8eec0e9ab4d15df66b22664dc4c
https://doi.org/10.1182/blood.v116.21.2780.2780
https://doi.org/10.1182/blood.v116.21.2780.2780
Autor:
Hua-Chen Chang, Ling Han, Ritobrata Goswami, Evelyn Thi Nguyen, David Pelloso, Michael J. Robertson, Mark H. Kaplan
Publikováno v:
The Journal of Immunology. 182:46.14-46.14
IL-12 activates STAT4, which is a critical regulator of inflammation and Th1 lineage development in murine systems. The requirement for STAT4 in the generation of human Th1 cells has not been examined thoroughly. Expression of the Th1 signature marke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20d29448a3d92c3663583e83218a9932
https://doi.org/10.4049/jimmunol.182.supp.46.14
https://doi.org/10.4049/jimmunol.182.supp.46.14
Publikováno v:
Blood. 108:3700-3700
Production of IFN-gamma is critical for optimal antitumor immune responses in several preclinical animal models. Patients with lymphoma who have undergone autologous hematopoietic stem cell transplantation exhibit profoundly diminished IFN-gamma prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b28f6b29135c957d9d0f46418fdce82
https://doi.org/10.1182/blood.v108.11.3700.3700
https://doi.org/10.1182/blood.v108.11.3700.3700