Výsledky vyhledávání - "David Peckham"

Akademický článek

A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors

Autor: Shawn Iadonato, Yulia Ovechkina, Kurt Lustig, Jessica Cross, Nathan Eyde, Emily Frazier, Neda Kabi, Chen Katz, Remington Lance, David Peckham, Shaarwari Sridhar, Carla Talbaux, Isabelle Tihista, Mei Xu, Thierry Guillaudeux

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundImmune checkpoint therapies have led to significant breakthroughs in cancer patient treatment in recent years. However, their efficiency is variable, and resistance to immunotherapies is common. VISTA is an immune-suppressive checkpoint inh

Externí odkaz: https://doaj.org/article/1bcf4547427541778d5e2eddbf4444bb

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Akademický článek

Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial.

Autor: Eric J Tarcha, Chelsea M Olsen, Peter Probst, David Peckham, Ernesto J Muñoz-Elías, James G Kruger, Shawn P Iadonato

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0180762 (2017)

Dalazatide is a specific inhibitor of the Kv1.3 potassium channel. The expression and function of Kv1.3 channels are required for the function of chronically activated memory T cells, which have been shown to be key mediators of autoimmune diseases,

Externí odkaz: https://doaj.org/article/f137890bf7c24d3ebf96fb3d4a62b3ef

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Abstract 972: VISTA expression in patients with advanced solid tumors: A potential biomarker in VISTA-101 clinical trial

Autor: Neda Kabi, Chen Katz, Remington Lance, Jessica Cross, Nathan Eyde, Emily Frazier, Kurt Lustig, Yulia Ovechkina, David Peckham, Shaarwari Sridhar, Carla Talbaux, Isabelle Tihista, Mei Xu, Shawn Iadonato, Thierry Guillaudeux

Publikováno v: Cancer Research. 83:972-972

V-domain Immunoglobulin Suppressor of T cell Activation (VISTA/PD-1H) is a B7 family member highly expressed on circulating and intra-tumoral myeloid cells. It is a negative checkpoint inhibitor that inhibits anti-tumor T cell response. In patients,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16668782e1089360485a1af9c956b499
https://doi.org/10.1158/1538-7445.am2023-972

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879 A promising cancer immunotherapy target: novel fully human agonist antibodies against the human T-cell costimulatory receptor CD27

Autor: Thierry Guillaudeux, Yulia Ovechkina, Eric J. Tarcha, David Jurchen, Shawn P. Iadonato, David Peckham, Emily Frazier, Shaarwari Sridhar

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundCD27 is a member of the TNF receptor superfamily and plays a critical role in T-cell activation by providing a costimulatory signal. CD27 signaling enhances T-cell proliferation, activation and differentiation of effector and memory T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153e8b0489beeed0ddf703e5321ee2f4
https://doaj.org/article/4790c3f21dfb4f7ca6e878ba872663fa

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Abstract 4261: CD27 a new immuno-oncology target shaping innate and adaptive anti-tumor immune responses

Autor: Thierry Guillaudeux, Yulia Ovechkina, Shaarwari Sridhar, David Peckham, Jessica Cross, Nathan Eyde, Emily Frazier, Neda Kabi, Remington Lance, Kurt Lustig, Mei Xu, Tarcha Eric, Shawn Iadonato

Publikováno v: Cancer Research. 82:4261-4261

CD27 is a member of the TNF-receptor superfamily, highly expressed on CD4+ and CD8+ T cells as well as on NK and NKT cells. It plays a key role on T cell proliferation and differentiation after stimulation with its ligand CD70. The co-stimulatory sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bba0bb983268dc8b658c8d03d089f92e
https://doi.org/10.1158/1538-7445.am2022-4261

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182 Highly potent fully human anti-VISTA antibodies – a new target checkpoint inhibitor against immunosuppressive myeloid cells

Autor: Thierry Guillaudeux, Eric Tarcha, Robert Bader, Benjamin Dutzar, Nathan Eyde, Emily Frazier, David Jurchen, Remington Lance, Cristina Loomis, Kurt Lustig, Yulia Ovechkina, David Peckham, Shaarwari Sridhar, Mei Xu, Shawn Iadonato, Jeff Posakony

Publikováno v: Regular and young investigator award abstracts.

Background V-domain Immunoglobulin Suppressor of T cell Activation (VISTA/PD-1H) is a B7 family ligand expressed on circulating and intratumoural myeloid cells as well as Treg and NK cells. It has been shown to inhibit T cell responses in vitro and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a70c7fe4017d15faa789c709761b5fef
https://doi.org/10.1136/jitc-2020-sitc2020.0182

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