Zobrazeno 1 - 10
of 111
pro vyhledávání: '"David Pantoja"'
Autor:
Rosa Antón, Miguel Á. Treviño, David Pantoja-Uceda, Sara Félix, María Babu, Eurico J. Cabrita, Markus Zweckstetter, Philip Tinnefeld, Andrés M. Vera, Javier Oroz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Abnormal trinucleotide repeat expansions alter protein conformation causing malfunction and contribute to a significant number of incurable human diseases. Scarce structural insights available on disease-related homorepeat expansions hinder
Externí odkaz:
https://doaj.org/article/3794aa1413964515962ab2aa2be23a71
Autor:
Jaime Carrasco, Rosa Antón, Alejandro Valbuena, David Pantoja-Uceda, Mayur Mukhi, Rubén Hervás, Douglas V. Laurents, María Gasset, Javier Oroz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
In this work, the authors show that metamorphism in the post-translationally modified TDP-43 prion-like domain encodes determinants that command mechanisms with major relevance in disease and stress the relevance of post-translationally modified chai
Externí odkaz:
https://doaj.org/article/9a9166e33ea74700a35643c8927458e0
Autor:
David Pantoja-Uceda, Cristiana Stuani, Douglas V Laurents, Ann E McDermott, Emanuele Buratti, Miguel Mompeán
Publikováno v:
PLoS Biology, Vol 19, Iss 4, p e3001198 (2021)
Transactive response DNA-binding Protein of 43 kDa (TDP-43) assembles various aggregate forms, including biomolecular condensates or functional and pathological amyloids, with roles in disparate scenarios (e.g., muscle regeneration versus neurodegene
Externí odkaz:
https://doaj.org/article/5c3974d5df084d1e8289dc404e4a15f8
Autor:
Valeria A. Risso, Sergio Martinez-Rodriguez, Adela M. Candel, Dennis M. Krüger, David Pantoja-Uceda, Mariano Ortega-Muñoz, Francisco Santoyo-Gonzalez, Eric A. Gaucher, Shina C. L. Kamerlin, Marta Bruix, Jose A. Gavira, Jose M. Sanchez-Ruiz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The emergence of novel catalytic functions in ancient proteins likely played a role in the evolution of modern enzymes. Here, the authors use protein sequences from Precambrian beta-lactamases and demonstrate that a single hydrophobic-to-ionizable am
Externí odkaz:
https://doaj.org/article/7c76aaa815614d3a948e230f4b0670e6
Autor:
David Pantoja Morán
Publikováno v:
Revista Mexicana de Ciencias Políticas y Sociales, Vol 49, Iss 201, Pp 85-109 (2007)
A partir de las discusiones habidas en el seno del Congreso Constituyente de 1824, el trabajo analiza el primer esfuerzo de reordenación de las finanzas públicas nacionales. Propone hacer una lectura política y sociológica, y no solo jurídica, d
Externí odkaz:
https://doaj.org/article/9c594cab2841429091096c9a110c9dfe
Autor:
David Pantoja Morán
Publikováno v:
Historia Mexicana El Colegio de México, Vol 64, Iss 2 (2014)
Externí odkaz:
https://doaj.org/article/10c0975db41748de9e89f68dc50527d6
Autor:
David Pantoja Morán
Publikováno v:
Revista Mexicana de Ciencias Políticas y Sociales, Vol 47, Iss 193, Pp 143-162 (2005)
En este artículo, el autor aborda el origen doctrinal de las dimensiones institucionales y constitucionales del sistema presidencial-constitucional mexicano para tratar de encontrar ahí los posibles orígenes o explicaciones del éxito o fracaso
Externí odkaz:
https://doaj.org/article/725ff73e91944c9399f1510410c0d631
Autor:
Maurício Morais, Héctor Zamora-Carreras, Paula D. Raposinho, Maria Cristina Oliveira, David Pantoja-Uceda, João D. G. Correia, M. Angeles Jiménez
Publikováno v:
Molecules, Vol 22, Iss 7, p 1189 (2017)
Linear and cyclic analogues of the α-melanocyte stimulating hormone (α-MSH) targeting the human melanocortin receptor 1 (MC1R) are of pharmacological interest for detecting and treating melanoma. The central sequence of α-MSH (His-Phe-Arg-Trp) has
Externí odkaz:
https://doaj.org/article/cbf5326e5dac4c2c88db4478c64bf0fc
Autor:
David Aguado-Llera, Tewfik Hamidi, Rosa Doménech, David Pantoja-Uceda, Meritxell Gironella, Jorge Santoro, Adrián Velázquez-Campoy, José L Neira, Juan L Iovanna
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78101 (2013)
The stress protein Nupr1 is a highly basic, multifunctional, intrinsically disordered protein (IDP). MSL1 is a histone acetyl transferase-associated protein, known to intervene in the dosage compensation complex (DCC). In this work, we show that both
Externí odkaz:
https://doaj.org/article/5d92fd0d15044e9892b0fd93e7dfb61c
Autor:
Alfredo De Biasio, Ramón Campos-Olivas, Ricardo Sánchez, Jorge P López-Alonso, David Pantoja-Uceda, Nekane Merino, Maider Villate, Jose M Martin-Garcia, Francisco Castillo, Irene Luque, Francisco J Blanco
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48390 (2012)
PCNA is an essential factor for DNA replication and repair. It forms a ring shaped structure of 86 kDa by the symmetric association of three identical protomers. The ring encircles the DNA and acts as a docking platform for other proteins, most of th
Externí odkaz:
https://doaj.org/article/44063a7f82b44aba8d88c7faa47436a8