Zobrazeno 1 - 10
of 31
pro vyhledávání: '"David Palesch"'
Autor:
Michelle Zanoni, David Palesch, Claudia Pinacchio, Maura Statzu, Gregory K Tharp, Mirko Paiardini, Ann Chahroudi, Steven E Bosinger, Jack Yoon, Bryan Cox, Guido Silvestri, Deanna A Kulpa
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008821 (2020)
MHC-I-restricted, virus-specific cytotoxic CD8+ T cells (CTLs) may control human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication via the recognition and killing of productively infected CD4+ T cells. Several studies i
Externí odkaz:
https://doaj.org/article/88b19171596b48d391661c9c882ff045
Autor:
Steffen Eipper, Robin Steiner, Adam Lesner, Marcin Sienczyk, David Palesch, Marc-Eric Halatsch, Ewa Zaczynska, Christopher Heim, Marcus D Hartmann, Michal Zimecki, Christian Rainer Wirtz, Timo Burster
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151509 (2016)
Protease-mediated degradation of proteins is critical in a plethora of physiological processes. Neutrophils secrete serine proteases including cathepsin G (CatG), neutrophile elastase (NE), and proteinase 3 (PR3) together with lactoferrin (LF) as a f
Externí odkaz:
https://doaj.org/article/d3ce30b2596a4d178a0a69b6c596b172
Autor:
Edina Lump, Laura M Castellano, Christoph Meier, Janine Seeliger, Nelli Erwin, Benjamin Sperlich, Christina M Stürzel, Shariq Usmani, Rebecca M Hammond, Jens von Einem, Gisa Gerold, Florian Kreppel, Kenny Bravo-Rodriguez, Thomas Pietschmann, Veronica M Holmes, David Palesch, Onofrio Zirafi, Drew Weissman, Andrea Sowislok, Burkhard Wettig, Christian Heid, Frank Kirchhoff, Tanja Weil, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Elsa Sanchez-Garcia, Roland Winter, James Shorter, Jan Münch
Publikováno v:
eLife, Vol 4 (2015)
Semen is the main vector for HIV transmission and contains amyloid fibrils that enhance viral infection. Available microbicides that target viral components have proven largely ineffective in preventing sexual virus transmission. In this study, we es
Externí odkaz:
https://doaj.org/article/0c9550c7aa694a08a411342bf36bd1d9
Autor:
Christina Martina Stürzel, David Palesch, Mohammad Khalid, Silke Wissing, Nicole Fischer, Jan Münch
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74427 (2013)
The gammaretrovirus termed xenotropic murine leukemia virus-related virus (XMRV) was described to be isolated from prostate cancer tissue biopsies and from blood of patients suffering from chronic fatigue syndrome. However, many studies failed to det
Externí odkaz:
https://doaj.org/article/73c3eb5aa6864ae58391c5e4aa3f12f6
Autor:
Fang Zou, Nadja Schäfer, David Palesch, Ruth Brücken, Alexander Beck, Marcin Sienczyk, Hubert Kalbacher, ZiLin Sun, Bernhard O Boehm, Timo Burster
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22815 (2011)
Autoantigenic peptides resulting from self-proteins such as proinsulin are important players in the development of type 1 diabetes mellitus (T1D). Self-proteins can be processed by cathepsins (Cats) within endocytic compartments and loaded to major h
Externí odkaz:
https://doaj.org/article/70dfaef387b04cc0a15572a686e743e5
Autor:
Ann Chahroudi, Gregory K. Tharp, Guido Silvestri, Mirko Paiardini, Steven E. Bosinger, Claudia Pinacchio, Michelle Zanoni, Deanna A. Kulpa, Jack Yoon, Bryan Cox, David Palesch, Maura Statzu
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008821 (2020)
PLoS Pathogens
PLoS Pathogens
MHC-I-restricted, virus-specific cytotoxic CD8+ T cells (CTLs) may control human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication via the recognition and killing of productively infected CD4+ T cells. Several studies i
Autor:
Joseph C. Mudd, R. Keith Reeves, Virginia Sheik, Brian Richardson, David Palesch, Andrea Lisco, Mirko Paiardini, Kathleen Busman-Sahay, Jacob D. Estes, Irini Sereti, Jason M. Brenchley, Stephen H. Lai, Sarah R. DiNapoli, Claire Deleage, Mark J. Cameron
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Innate lymphoid cells (ILCs) play critical roles in mucosal barrier defense and tissue homeostasis. While ILCs are depleted in HIV-1 infection, this phenomenon is not a generalized feature of all viral infections. Here we show in untreated SIV-infect
Autor:
Kim C. Worley, Muthuswamy Raveendran, Mirko Paiardini, Matthew W. Hahn, R. Alan Harris, Gregory K. Tharp, Donald L. Sodora, Daniel Sauter, Guido Silvestri, David Palesch, Reem A. Dawoud, Sara M. Seepo, Richard A. Gibbs, Jeffrey Rogers, Thomas H. Vanderford, Yi Han, Caro-Beth Stewart, Frank Kirchhoff, Gregg W.C. Thomas, Donna M. Muzny, Nirav B. Patel, Ann Chahroudi, Beatrice H. Hahn, Adam C. English, Robert B. Norgren, Yue Liu, Zachary P. Johnson, Christopher E. Mason, Steven E. Bosinger, Lenore Pipes
Publikováno v:
Nature
In contrast to infections with human immunodeficiency virus (HIV) in humans and simian immunodeficiency virus (SIV) in macaques, SIV infection of a natural host, sooty mangabeys (Cercocebus atys), is non-pathogenic despite high viraemia1. Here we seq
Autor:
Henintsoa, Rabezanahary, Félicien, Moukambi, David, Palesch, Julien, Clain, Gina, Racine, Guadalupe, Andreani, Ghita, Benmadid-Laktout, Ouafa, Zghidi-Abouzid, Calayselvy, Soundaramourty, Cécile, Tremblay, Guido, Silvestri, Jérôme, Estaquier
Publikováno v:
Mucosal Immunology
Whereas antiretroviral therapy (ART) suppresses viral replication, ART discontinuation results in viral rebound, indicating the presence of viral reservoirs (VRs) established within lymphoid tissues. Herein, by sorting CD4 T-cell subsets from the spl
Autor:
Maud Mavigner, Emily K. Cartwright, Guido Silvestri, Mirko Paiardini, David Palesch, Ann Chahroudi
Publikováno v:
Journal of Virology. 90:6699-6708
Treatment of human immunodeficiency virus (HIV) infection with antiretroviral therapy (ART) has significantly improved prognosis. Unfortunately, interruption of ART almost invariably results in viral rebound, attributed to a pool of long-lived, laten