Zobrazeno 1 - 10
of 171
pro vyhledávání: '"David PIRES"'
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 848 (2024)
Tuberculosis and AIDS remain two of the most relevant human infectious diseases. The pathogens that cause them, Mycobacterium tuberculosis (Mtb) and HIV, individually elicit an immune response that treads the line between beneficial and detrimental t
Externí odkaz:
https://doaj.org/article/a8737089735848548b75be701e76fa54
Autor:
João P. Pais, Olha Antoniuk, David Pires, Tiago Delgado, Andreia Fortuna, Paulo J. Costa, Elsa Anes, Luis Constantino
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 608 (2024)
Tuberculosis (TB) is a disease that plagues the frailest members of society. We have developed a family of N-alkyl nitrobenzamides that exhibit promising antitubercular activities and can be considered a structural simplification of known inhibitors
Externí odkaz:
https://doaj.org/article/c9a92fb65a89432a8cf1b066f95ee090
Autor:
Tiago Delgado, João P. Pais, David Pires, Filipe G. A. Estrada, Rita C. Guedes, Elsa Anes, Luis Constantino
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 559 (2024)
Tuberculosis (TB) continues to be a major global health challenge and a leading cause of death from infectious diseases. Inspired by the results from a previous work by our group on antimycobacterial N-alkylnitrobenzamides, which are structurally rel
Externí odkaz:
https://doaj.org/article/5143a65786274f779874a2bd07b31276
Publikováno v:
BMC Health Services Research, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Congestive heart failure (CHF) is a significant health problem in Australia, and disproportionately affects rural Australians. Management of CHF in Australia is heavily centred around the general practitioner (GP). Australian and
Externí odkaz:
https://doaj.org/article/2cf53a4ca6bc4d51b7b52cc394c3dd18
Autor:
Cátia Silveiro, Mariana Marques, Francisco Olivença, David Pires, Diana Mortinho, Alexandra Nunes, Madalena Pimentel, Elsa Anes, Maria João Catalão
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
The lack of effective therapeutics against emerging multi-drug resistant strains of Mycobacterium tuberculosis (Mtb) prompts the identification of novel anti-tuberculosis targets. The essential nature of the peptidoglycan (PG) layer of the mycobacter
Externí odkaz:
https://doaj.org/article/4398c16770e648bab823c479db2a3ad7
Publikováno v:
Microorganisms, Vol 11, Iss 7, p 1861 (2023)
Tuberculosis (TB) treatment relies primarily on 70-year-old drugs, and prophylaxis suffers from the lack of an effective vaccine. Among the 10 million people exhibiting disease symptoms yearly, 450,000 have multidrug or extensively drug-resistant (MD
Externí odkaz:
https://doaj.org/article/2b6bdd2aff4f4531a9716597f03217b6
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cathepsins were first described, as endolysosomal proteolytic enzymes in reference to the organelles where they degrade the bulk of endogenous and exogenous substrates in a slightly acidic environment. These substrates include pathogens internalized
Externí odkaz:
https://doaj.org/article/be8c1c915c8144ddac1aadf716b4b5af
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 968 (2023)
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of the most successfully adapted human pathogens. Human-to-human transmission occurs at high rates through aerosols containing bacteria, but the pathogen evolved
Externí odkaz:
https://doaj.org/article/95e5b7fa88264b2393d146c3daf67db4
Autor:
Marta Calado, David Pires, Carolina Conceição, Rita Ferreira, Quirina Santos-Costa, Elsa Anes, José Miguel Azevedo-Pereira
Publikováno v:
Viruses, Vol 15, Iss 5, p 1030 (2023)
Macrophages (Mø) and dendritic cells (DCs) are key players in human immunodeficiency virus (HIV) infection and pathogenesis. They are essential for the spread of HIV to CD4+ T lymphocytes (TCD4+) during acute infection. In addition, they constitute
Externí odkaz:
https://doaj.org/article/a08003afa1d1452d9d25d8f1c056e0fa
Autor:
David Pires, Manoj Mandal, Ana I. Matos, Carina Peres, Maria João Catalão, José Miguel Azevedo-Pereira, Ronit Satchi-Fainaro, Helena F. Florindo, Elsa Anes
Publikováno v:
Antibiotics, Vol 12, Iss 4, p 729 (2023)
The golden age of antibiotics for tuberculosis (TB) is marked by its success in the 1950s of the last century. However, TB is not under control, and the rise in antibiotic resistance worldwide is a major threat to global health care. Understanding th
Externí odkaz:
https://doaj.org/article/fd4ab8f8cb614e7bbe58b5d7533af708