Zobrazeno 1 - 10
of 93
pro vyhledávání: '"David P. Weiner"'
Autor:
Tríona‐Marie Dooley‐Cullinane, Catherine O'Reilly, Bilal Aslam, David P. Weiner, David O'Neill, Erica Owens, Denise O'Meara, Lee Coffey
Publikováno v:
MicrobiologyOpen, Vol 8, Iss 4, Pp n/a-n/a (2019)
Abstract Nitrilase enzymes (EC 3.5.5.1) are responsible for the direct hydration of nitriles to their corresponding carboxylic acids and ammonia. The utilization of nitrilase enzymes in biocatalysis toward bio‐pharmaceuticals and industrial applica
Externí odkaz:
https://doaj.org/article/11ed707fd9b9451c9c1ffe802b1287c4
Autor:
Ami Patel, Kyle Rosenke, Elizabeth M. Parzych, Friederike Feldmann, Suman Bharti, Amanda J. Griffin, Blake Schouest, Matt Lewis, Jihae Choi, Neethu Chokkalingam, Viviane Machado, Brian J. Smith, Drew Frase, Ali R. Ali, Jamie Lovaglio, Brian Nguyen, Patrick W. Hanley, Susanne N. Walker, Ebony N. Gary, Abhijeet Kulkarni, Allison Generotti, Joseph R. Francica, Kim Rosenthal, Daniel W. Kulp, Mark T. Esser, Trevor R. F. Smith, Carl Shaia, David B. Weiner, Heinz Feldmann
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTCOVID-19 remains a major public health concern. Monoclonal antibodies have received emergency use authorization (EUA) for pre-exposure prophylaxis against COVID-19 among high-risk groups for treatment of mild to moderate COVID-19. In addition
Externí odkaz:
https://doaj.org/article/b981edf4969f4fdb9843528b197ac517
Publikováno v:
Journal of Dermatological Treatment, Vol 35, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/8520089ab9ad4f519b04b84f131ad2d2
Autor:
Daniel H. Park, Kevin Liaw, Pratik Bhojnagarwala, Xizhou Zhu, Jihae Choi, Ali R. Ali, Devivasha Bordoloi, Ebony N. Gary, Ryan P. O’Connell, Abhijeet Kulkarni, Diana Guimet, Trevor Smith, Alfredo Perales-Puchalt, Ami Patel, David B. Weiner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 249-263 (2023)
Glioblastoma multiforme (GBM) is among the most difficult cancers to treat with a 5-year survival rate less than 5%. An immunotherapeutic vaccine approach targeting GBM-specific antigen, EGFRvIII, previously demonstrated important clinical impact. Ho
Externí odkaz:
https://doaj.org/article/711f820743e943359c7145d81fe55987
Autor:
Elizabeth M. Parzych, Jianqiu Du, Ali R. Ali, Katherine Schultheis, Drew Frase, Trevor R. F. Smith, Jiayan Cui, Neethu Chokkalingam, Nicholas J. Tursi, Viviane M. Andrade, Bryce M. Warner, Ebony N. Gary, Yue Li, Jihae Choi, Jillian Eisenhauer, Igor Maricic, Abhijeet Kulkarni, Jacqueline D. Chu, Gabrielle Villafana, Kim Rosenthal, Kuishu Ren, Joseph R. Francica, Sarah K. Wootton, Pablo Tebas, Darwyn Kobasa, Kate E. Broderick, Jean D. Boyer, Mark T. Esser, Jesper Pallesen, Dan W. Kulp, Ami Patel, David B. Weiner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here, Parzych et al describe the development of a DNA-delivered SARS-CoV-2 mAb cocktail displaying synergistic RBD binding that confers broad neutralizing activity against variants of concern and prophylactic efficacy in multiple small animal models.
Externí odkaz:
https://doaj.org/article/dec1ebc23ee2448fb7ad32d2457e1b56
Autor:
Nicholas J. Tursi, Sophia M. Reeder, Yevel Flores-Garcia, Mamadou A. Bah, Shamika Mathis-Torres, Berenice Salgado-Jimenez, Rianne Esquivel, Ziyang Xu, Jacqueline D. Chu, Laurent Humeau, Ami Patel, Fidel Zavala, David B. Weiner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Novel approaches for malaria prophylaxis remain important. Synthetic DNA-encoded monoclonal antibodies (DMAbs) are a promising approach to generate rapid, direct in vivo host-generated mAbs with potential benefits in production simplicity an
Externí odkaz:
https://doaj.org/article/2a9b0778593442f08dfbfe70da161a9c
Autor:
Narendranath Epperla, Qiuhong Zhao, Sayan Mullick Chowdhury, Lauren Shea, Tamara K. Moyo, Nishitha Reddy, Julia Sheets, David M. Weiner, Praveen Ramakrishnan Geethakumari, Malathi Kandarpa, Ximena Jordan Bruno, Colin Thomas, Michael C. Churnetski, Andrew Hsu, Luke Zurbriggen, Cherie Tan, Kathryn Lindsey, Joseph Maakaron, Paolo F. Caimi, Pallawi Torka, Celeste Bello, Sabarish Ayyappan, Reem Karmali, Seo-Hyun Kim, Anna Kress, Shalin Kothari, Yazeed Sawalha, Beth Christian, Kevin A. David, Irl Brian Greenwell, Murali Janakiram, Vaishalee P. Kenkre, Adam J. Olszewski, Jonathon B. Cohen, Neil Palmisiano, Elvira Umyarova, Ryan A. Wilcox, Farrukh T. Awan, Juan Pablo Alderuccio, Stefan K. Barta, Natalie S. Grover, Nilanjan Ghosh, Nancy L. Bartlett, Alex F. Herrera, Geoffrey Shouse
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-6 (2022)
Abstract Ibrutinib is effective in the treatment of relapsed/refractory (R/R) marginal zone lymphoma (MZL) with an overall response rate (ORR) of 48%. However, factors associated with response (or lack thereof) to ibrutinib in R/R MZL in clinical pra
Externí odkaz:
https://doaj.org/article/742e9377f2884da1b8eeb0b6ff560e57
Autor:
Ebony N. Gary, Nicholas J. Tursi, Bryce M. Warner, Gina Cuismano, Jennifer Connors, Elizabeth M. Parzych, Bryan D. Griffin, Matthew R. Bell, Ali R. Ali, Drew Frase, Casey E. Hojecki, Gabriela A. Canziani, Irwin Chaiken, Toshitha Kannan, Estella Moffat, Carissa Embury-Hyatt, Sarah K. Wooton, Andrew Kossenkov, Ami Patel, Darwyn Kobasa, Michele A. Kutzler, Elias K. Haddad, David B. Weiner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Despite numerous clinically available vaccines and therapeutics, aged patients remain at increased risk for COVID-19 morbidity. Furthermore, various patient populations, including the aged can have suboptimal responses to SARS-CoV-2 vaccine antigens.
Externí odkaz:
https://doaj.org/article/54e6d5648e304ae68b9b6bf090ee114c
Autor:
Xizhou Zhu, Alfredo Perales-Puchalt, Krzysztof Wojtak, Ziyang Xu, Kun Yun, Pratik S. Bhojnagarwala, Devivasha Bordoloi, Daniel H. Park, Kevin Liaw, Mamadou A. Bah, Paul M. Lieberman, Ebony N. Gary, Ami Patel, David B. Weiner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 218-229 (2022)
Latent Epstein-Barr virus (EBV) infection is associated with several types of cancer. Several clinical studies have targeted EBV antigens as immune therapeutic targets with limited efficacy of EBV malignancies, suggesting that additional targets migh
Externí odkaz:
https://doaj.org/article/f6f4c101657c4f7aa88799ba04927cda
Autor:
Ziyang Xu, Susanne Walker, Megan C. Wise, Neethu Chokkalingam, Mansi Purwar, Alan Moore, Edgar Tello-Ruiz, Yuanhan Wu, Sonali Majumdar, Kylie M. Konrath, Abhijeet Kulkarni, Nicholas J. Tursi, Faraz I. Zaidi, Emma L. Reuschel, Ishaan Patel, April Obeirne, Jianqiu Du, Katherine Schultheis, Lauren Gites, Trevor Smith, Janess Mendoza, Kate E. Broderick, Laurent Humeau, Jesper Pallesen, David B. Weiner, Daniel W. Kulp
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
HIV envelope is a target for vaccine development, but induction of broadly neutralizing antibodies has been difficult. Here, the authors show that electroporation with a synthetic DNA vaccine construct allows in vivo production of HIV envelope native
Externí odkaz:
https://doaj.org/article/35ba9a407faa49de8522273b74f5d21c