Zobrazeno 1 - 10
of 15
pro vyhledávání: '"David P. Sparling"'
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 326-335 (2020)
Adipocyte-mediated inflammatory signalling has been proposed to alter adipose physiology in obesity and Type 2 diabetes mellitus. Novel targets for alteration of inflammatory signalling are needed to improve obesity-related outcomes. The γ-secretase
Externí odkaz:
https://doaj.org/article/942cc493fb034abea8d2689a4faeb9ab
Autor:
David P. Sparling, Junjie Yu, KyeongJin Kim, Changyu Zhu, Sebastian Brachs, Andreas L. Birkenfeld, Utpal B. Pajvani
Publikováno v:
Molecular Metabolism, Vol 5, Iss 2, Pp 113-121 (2016)
Objective: As the obesity pandemic continues to expand, novel molecular targets to reduce obesity-related insulin resistance and Type 2 Diabetes (T2D) continue to be needed. We have recently shown that obesity is associated with reactivated liver Not
Externí odkaz:
https://doaj.org/article/5cd97b3acb34442aa129a27401d92fbc
Autor:
KyeongJin Kim, Li Qiang, Matthew S. Hayden, David P. Sparling, Nicole H. Purcell, Utpal B. Pajvani
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The protein raptor is a subunit of the mTORC signalling complex. Here the authors show that Raptor also exists in a free form, unbound to mTORC, and that this free Raptor negatively regulates hepatic Akt activity and lipid metabolism in mice via a me
Externí odkaz:
https://doaj.org/article/4557982e90754044bc5dda4f28d8a993
Autor:
Joni K. Beck, Rebecca A. Allen, Kathryn M. Jeter, Rachel S. Fisher, Taylor M. Dattilo, Katherine A. Traino, Michael Anderson, James Cutler, David P. Sparling
Publikováno v:
Pediatric Diabetes. 2023:1-10
Real-time continuous glucose monitoring (rtCGM) can directly improve patient outcomes, including decreased health care system utilization and associated costs. The purpose of this study was to evaluate the clinical benefits of rtCGM use in a high-ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b671e510b0e3079ca8a0389b183cbf
https://doi.org/10.1155/2023/5253515
https://doi.org/10.1155/2023/5253515
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 326-335 (2020)
Adipocyte
article-version (VoR) Version of Record
Adipocyte
article-version (VoR) Version of Record
Adipocyte-mediated inflammatory signalling has been proposed to alter adipose physiology in obesity and Type 2 diabetes mellitus. Novel targets for alteration of inflammatory signalling are needed to improve obesity-related outcomes. The γ-secretase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379782056c96e48f8551896fcbb51cd5
https://doi.org/10.1080/21623945.2020.1788235
https://doi.org/10.1080/21623945.2020.1788235
Autor:
Ann Louise Olson, David P. Sparling, Beth A. Griesel, Willard M. Freeman, Robert M. Jackson, Kevin R. Short
Publikováno v:
Obesity (Silver Spring)
Objective Obesity is a major risk factor for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus, whereas weight loss is associated with improved health outcomes. It is therefore important to learn how adipose contraction during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dea82aa18ae5f634543a6a26fec7f77
https://doi.org/10.1002/oby.22652
https://doi.org/10.1002/oby.22652
Autor:
David P. Sparling, Shaoning Jiang, Jeanie B. Tryggestad, April M. Teague, Steven D. Chernausek
Publikováno v:
Obesity (Silver Spring)
Objective This study aimed to investigate cellular sources of microRNAs (miRNA) within adipose tissue and the impact of obesity on miRNA expression, as well as to examine targets of miRNAs. Methods miRNA expression by quantitative polymerase chain re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd7eb7783de10f580fe07a2aed921f3
https://doi.org/10.1002/oby.22616
https://doi.org/10.1002/oby.22616
Autor:
Michael Tansey, Stephanie N. DuBose, Ruth S. Weinstock, David P. Sparling, Zoey Li, Viral N. Shah, William V. Tamborlane, Davida F. Kruger, Sara E Watson, Francesco Vendrame, Anne L. Peters, Stephanie Woerner, Roy W. Beck, Jennifer L. Sherr, Richard M. Bergenstal
Publikováno v:
J Clin Endocrinol Metab
Context Use of continuous glucose monitoring (CGM) is increasing for insulin-requiring patients with diabetes. Although data on glycemic profiles of healthy, nondiabetic individuals exist for older sensors, assessment of glycemic metrics with new-gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1e85246cd616418da47ba31c1e6721
https://doi.org/10.1210/jc.2018-02763
https://doi.org/10.1210/jc.2018-02763
Autor:
Sheri L. Stone, Nudrat Noor, Robert Rapaport, David P. Sparling, Laura Levin, Osagie Ebekozien, David M. Maahs
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Objective We examined whether diabetic ketoacidosis (DKA), a serious complication of type 1 diabetes (T1D) was more prevalent among Non-Hispanic (NH) Black and Hispanic patients with T1D and laboratory-confirmed coronavirus disease 2019 (COVID-19) co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33018fb79bbc8cfe61b4a082cf96cf1d
https://pubmed.ncbi.nlm.nih.gov/33410917
https://pubmed.ncbi.nlm.nih.gov/33410917
Autor:
Nicole H. Purcell, Li Qiang, Kyeong Jin Kim, David P. Sparling, Matthew S. Hayden, Utpal B. Pajvani
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Mechanistic target of rapamycin complex 1 (mTORC1), defined by the presence of Raptor, is an evolutionarily conserved and nutrient-sensitive regulator of cellular growth and other metabolic processes. To date, all known functions of Raptor involve it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb447abd6084e4f2f2819e02cc5a5fb1
https://doi.org/10.1038/ncomms10255
https://doi.org/10.1038/ncomms10255