Zobrazeno 1 - 10
of 310
pro vyhledávání: '"David P. Siderovski"'
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Cognitive decline in Parkinson’s disease (PD) is a critical premotor sign that may occur in approximately 40% of PD patients up to 10 years prior to clinical recognition and diagnosis. Delineating the mechanisms and specific behavioral signs of cog
Externí odkaz:
https://doaj.org/article/96f62cda69934543be6094b7c62b33e8
Autor:
Adam B Schroer, Junaith S Mohamed, Melinda D Willard, Vincent Setola, Emily Oestreich, David P Siderovski
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0216167 (2019)
Regulators of G Protein Signaling (RGS proteins) inhibit G protein-coupled receptor (GPCR) signaling by accelerating the GTP hydrolysis rate of activated Gα subunits. Some RGS proteins exert additional signal modulatory functions, and RGS12 is one s
Externí odkaz:
https://doaj.org/article/91c5797ef9b144e89da277b344d6565d
Autor:
Tresa George, Matthew Bell, Mainak Chakraborty, David P Siderovski, Mark A Giembycz, Robert Newton
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170269 (2017)
The GTPase-accelerating protein, regulator of G-protein signalling 2 (RGS2) reduces signalling from G-protein-coupled receptors (GPCRs) that signal via Gαq. In humans, RGS2 expression is up-regulated by inhaled corticosteroids (ICSs) and long-acting
Externí odkaz:
https://doaj.org/article/572fe8d91a2047e4a7e647fc646c4bf5
Autor:
Sara C. Campbell, Marko Oydanich, Jie Zhang, Candace R. Longoria, Dorothy E. Vatner, David P. Siderovski, Stephen F. Vatner
Publikováno v:
The FASEB Journal. 36
Potential for Kappa-Opioid Receptor Agonists to Engineer Nonaddictive Analgesics: A Narrative Review
Publikováno v:
Anesth Analg
A serious adverse effect of prescription opioid analgesics is addiction, both to these analgesics and to illicit drugs like heroin that also activate the mu opioid receptor (MOR). Opioid Use Disorder (OUD) and opioid overdose deaths represent a curre
Autor:
Joshua D Gross, Kristen R Trexler, Vincent Setola, William C. Wetsel, Shane W Kaski, Allison N White, Kim Wix, Steven G. Kinsey, David P. Siderovski
Publikováno v:
J Psychopharmacol
Background:Regulator of G protein Signaling (RGS) proteins inhibit G protein-coupled receptor (GPCR) signaling, including the signals that arise from neurotransmitter release. We have shown that RGS12 loss diminishes locomotor responses of C57BL/6J m
Publikováno v:
Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology ISBN: 9783031123979
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7cd6381ce01b3154b626b2e03a71551
https://doi.org/10.1007/978-3-031-12398-6_14
https://doi.org/10.1007/978-3-031-12398-6_14
Autor:
Sara C Campbell, Marko Oydanich, Jie Zhang, Candace R Longoria, Olufunmilola Ibironke, Dorothy E Vatner, David P Siderovski, Stephen F Vatner
Publikováno v:
Circulation. 144
The Regulator of G Protein Signaling 14 knockout (RGS14 KO) mouse strain has a unique brown adipose tissue (BAT) mechanism mediating its phenotype of healthful longevity and improved exercise performance. RGS14 KO mice demonstrated a 51 ± 8% increas
Autor:
Paul D. Chantler, Joshua D Gross, Adam B. Schroer, Kayla W. Branyan, Adam J. Kimple, David P. Siderovski, Aurelie Vandenbeuch
Publikováno v:
Chem Senses
The T1R and T2R families of G protein-coupled receptors (GPCRs) initiate tastant perception by signaling via guanine nucleotide exchange and hydrolysis performed by associated heterotrimeric G proteins (Gαβγ). Heterotrimeric G protein signal termi
Autor:
Michel Guipponi, Federico A Santoni, Vincent Setola, Corinne Gehrig, Maud Rotharmel, Macarena Cuenca, Olivier Guillin, Dimitris Dikeos, Georgios Georgantopoulos, George Papadimitriou, Logos Curtis, Alexandre Méary, Franck Schürhoff, Stéphane Jamain, Dimitri Avramopoulos, Marion Leboyer, Dan Rujescu, Ann Pulver, Dominique Campion, David P Siderovski, Stylianos E Antonarakis
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141630 (2015)
Externí odkaz:
https://doaj.org/article/963ed32e16e74ae781d3e8f65c32befa