Zobrazeno 1 - 10
of 32
pro vyhledávání: '"David P. Nowotnik"'
Autor:
David P. Nowotnik
Publikováno v:
Current Bioactive Compounds. 7:21-26
Autor:
Jaafar Bennouna, David P. Nowotnik, Jeany M. Rademaker-Lakhai, Stephen B. Howell, Jan H.M. Schellens, Jos H. Beijnen, Mario Campone
Publikováno v:
Cancer Chemotherapy and Pharmacology. 60:523-533
To determine the maximum tolerated dose (MTD) safety and pharmacokinetics of AP5346, a copolymer-linked 1,2-diaminocyclohexane(DACH)-platinum compound, in advanced solid tumor patients.AP5346 was administered as a 1-hour IV infusion on days 1, 8, 15
Publikováno v:
Clinical Cancer Research. 12:2248-2254
Purpose: AP5346 is designed to target a diaminocyclohexane platinum (Pt) moiety to tumors through pH-sensitive linkage to a 25 kDa hydroxypropylmethacrylamide polymer. The goal of these studies was to determine the rate of release of Pt as a function
Autor:
Michael A. Taylor, Dimitrios Papadopoulos, David E. Pruitt, Charles J. Meakin, Doug F. Ciuba, David P. Nowotnik, Dwight E. Heron, Grace E. Yuh, Ranjini Gandhavadi, Youssef Arshoun, Aaron A. Ambrad, Richard J. Carmel, William M. Wisbeck, Stephen T. Sonis, Ron R. Allison, Steven E. Finkelstein, Elizabeth Feldman, Steven C. Lane, John M. Longo, Lynn M. Steinbrenner
Publikováno v:
Cancer
BACKGROUND The objective of this trial was to determine how a mucoadhesive hydrogel (MuGard), a marketed medical device, would fare when tested with the strictness of a conventional multi‐institutional, double‐blind, randomized, placebo‐control
Autor:
David P. Nowotnik, K. Ramalingam, Adrian D. Nunn, Silvia S. Jurisson, Di Rocco Richard J, Rama K. Narra, Bruce L. Kuczynski
Publikováno v:
Nuclear Medicine and Biology. 22:625-634
To prepare less lipophilic BATO complexes, two new methoxy-substituted dioximes were synthesized: cis-4,5-dimethoxycyclohexane-1,2-dione dioxime (DMCDO) and 1,4-dimethoxybutane-2,3-dione dioxime (DMDMG). 99mTcCl(DMCDO)3BMe (BMe = methylboronic acid)
Autor:
William C. Eckelman, Silvia S. Jurisson, Adrian D. Nunn, Elaine Jagoda, P. Nanjappan, Pirro John P, David P. Nowotnik, Karen C. Rosenspire, Richard J. DiRocco
Publikováno v:
Nuclear Medicine and Biology. 22:269-281
We have investigated the possibility of using BATO complexes derivatized with the muscarinic acetylcholine receptor (mAChR) antagonist, quinuclidinyl benzilate (QNB), for mAChR imaging. The BATO complexes, TcCl(DMG)3B-QNB, were prepared using QNB der
Publikováno v:
Tetrahedron. 51:2875-2894
A series of 2-substituted-1,3-diaminopropanes ( 1b-1f, 1h ) have been synthesized as precursors to nitroimidazole-substituted 3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime ( 21b, 21d, 21e and 26a-26c ) (Propylene Amine Oxime, PnAO) ligands
Publikováno v:
Journal of Liquid Chromatography. 18:673-687
The Resolvosil BSA-7, Chiracel OD, and Chiralpak AD columns were examined to determine whether one might be suitable for the separation of enatiomers of the ligand hexamethyl-propyleneamine oxime (HM-PAO) and/or its technetium-99m complex. Using hexa
Autor:
Rama K. Narra, Bruce L. Kuczynski, John E. Cyr, Yee Wai Chan, Di Rocco Richard J, Pirro John P, Al A. Bauer, K. Ramalingam, Adrian D. Nunn, N. Raju, David P. Nowotnik, K. E. Linder
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 13:755-762
Autoradiograms obtained after middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats show that the 99mTc complex of a 2-nitroimidazole-derivatized propylene amine oxime (BMS-181321) is selectively retained in acutely ischemic brai