Zobrazeno 1 - 10
of 190
pro vyhledávání: '"David P. Lewis"'
Autor:
Cynthia M. Arokiaraj, Michael J. Leone, Michael Kleyman, Alexander Chamessian, Myung-Chul Noh, BaDoi N. Phan, Bettega C. Lopes, Kelly A. Corrigan, Vijay Kiran Cherupally, Deepika Yeramosu, Michael E. Franusich, Riya Podder, Sumitra Lele, Stephanie Shiers, Byungsoo Kang, Meaghan M. Kennedy, Viola Chen, Ziheng Chen, Hansruedi Mathys, Richard P. Dum, David A. Lewis, Yawar Qadri, Theodore J. Price, Andreas R. Pfenning, Rebecca P. Seal
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114876- (2024)
Summary: Key mechanisms underlying chronic pain occur within the dorsal horn. Genome-wide association studies (GWASs) have identified genetic variants predisposed to chronic pain. However, most of these variants lie within regulatory non-coding regio
Externí odkaz:
https://doaj.org/article/3f588436835441efb2ed009e8dffb3e7
Autor:
Philip A Wheeler, Nicholas S West, Richard Powis, Rhydian Maggs, Michael Chu, Rachel A Pearson, Nick Willis, Bartlomiej Kurec, Katie L. Reed, David G. Lewis, John Staffurth, Emiliano Spezi, Anthony E. Millin
Publikováno v:
Radiation Oncology, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background Current automated planning solutions are calibrated using trial and error or machine learning on historical datasets. Neither method allows for the intuitive exploration of differing trade-off options during calibration, which may
Externí odkaz:
https://doaj.org/article/e896d6b30ee2484b927251cdf6a63ef2
Publikováno v:
Frontiers in Environmental Archaeology, Vol 3 (2024)
Fire is a key disturbance process that shapes the structure and function of montane temperate rainforest in the Pacific Northwest (PNW). Recent research is revealing more frequent historical fire activity in the western central Cascades than expected
Externí odkaz:
https://doaj.org/article/9f1c138c046c434894a42ccd9e8a0605
Autor:
BaDoi N. Phan, Madelyn H. Ray, Xiangning Xue, Chen Fu, Robert J. Fenster, Stephen J. Kohut, Jack Bergman, Suzanne N. Haber, Kenneth M. McCullough, Madeline K. Fish, Jill R. Glausier, Qiao Su, Allison E. Tipton, David A. Lewis, Zachary Freyberg, George C. Tseng, Shelley J. Russek, Yuriy Alekseyev, Kerry J. Ressler, Marianne L. Seney, Andreas R. Pfenning, Ryan W. Logan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract In brain, the striatum is a heterogenous region involved in reward and goal-directed behaviors. Striatal dysfunction is linked to psychiatric disorders, including opioid use disorder (OUD). Striatal subregions are divided based on neuroanato
Externí odkaz:
https://doaj.org/article/82f5489316cf4dc69335f0d491c9b09c
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Background and objectiveAberrant epigenetic regulation and increased oxidative stress in the placenta play a significant role in placental pathophysiology and fetal programming in preeclampsia, a hypertensive disorder in human pregnancy. The purpose
Externí odkaz:
https://doaj.org/article/11779194e98f4d6085a639f4df75e6fa
Autor:
Eric P F Chow, Christopher K Fairley, Marcus Y Chen, Basil Donovan, Fengyi Jin, Andrew E Grulich, Anna McNulty, Matthew Law, Kate L Seib, Brent Mackie, David A Lewis, Benjamin R Bavinton, David M Whiley, Caroline Thng, Monica M Lahra, Amy V Jennison, Barbara Yeung, Doug Fraser, Michael P Jennings
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction Gonorrhoea, the sexually transmissible infection caused by Neisseria gonorrhoeae, has a substantial impact on sexual and reproductive health globally with an estimated 82 million new infections each year worldwide. N. gonorrhoeae antimic
Externí odkaz:
https://doaj.org/article/75a4a901698349c5862681484babd0a1
Autor:
Caroline R. Perry, Nicole E. Scangarella-Oman, Helen Millns, William Flight, Sally Gatsi, Charles Jakielaszek, Salim Janmohamed, David A. Lewis
Publikováno v:
Infectious Diseases and Therapy, Vol 12, Iss 9, Pp 2307-2320 (2023)
Abstract Introduction Gonorrhea, caused by Neisseria gonorrhoeae (NG), is the second most common bacterial sexually transmitted infection (STI). Rates of antimicrobial resistance to standard care are increasing worldwide, with many antibiotic classes
Externí odkaz:
https://doaj.org/article/cc36ad392f934716b949adc17100ac8c
Autor:
Piotr Dzien, Agata Mackintosh, Gaurav Malviya, Emma Johnson, Dmitry Soloviev, Gavin Brown, Alejandro Huerta Uribe, Colin Nixon, Scott K. Lyons, Oliver Maddocks, Karen Blyth, David Y. Lewis
Publikováno v:
Cancer & Metabolism, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Background Tissue environment is critical in determining tumour metabolic vulnerability. However, in vivo drug testing is slow and waiting for tumour growth delay may not be the most appropriate endpoint for metabolic treatments. An in vivo
Externí odkaz:
https://doaj.org/article/054ecccc8bf24e56a8d145f064232de3
Autor:
Joseph R. Merrill, Alessandra Inguscio, Taemoon Chung, Breanna Demestichas, Libia A. Garcia, Jill Habel, David Y. Lewis, Tobias Janowitz, Scott K. Lyons
Publikováno v:
Cell Stress, Vol 7, Iss 8, Pp 59-68 (2023)
Non-invasive imaging of tumors expressing reporter transgenes is a popular preclinical method for studying tumor development and response to therapy in vivo due to its ability to distinguish signal from tumors over background noise. However, the util
Externí odkaz:
https://doaj.org/article/48a7a68f22f346339e6f85ed6593c731
Publikováno v:
Neurobiology of Disease, Vol 191, Iss , Pp 106394- (2024)
Background: Dorsolateral prefrontal cortex (DLPFC) dysfunction in schizophrenia appears to reflect alterations in layer 3 pyramidal neurons (L3PNs), including smaller cell bodies and lower expression of mitochondrial energy production genes. However,
Externí odkaz:
https://doaj.org/article/59ffa2dcc3244045869c1f9fc092a9d7