Zobrazeno 1 - 10
of 34
pro vyhledávání: '"David P. Jacobson"'
Autor:
Pushkar S. Sathe, Caitlyn M. Wolf, Youngju Kim, Sarah M. Robinson, M. Cyrus Daugherty, Ryan P. Murphy, Jacob M. LaManna, Michael G. Huber, David L. Jacobson, Paul A. Kienzle, Katie M. Weigandt, Nikolai N. Klimov, Daniel S. Hussey, Peter Bajcsy
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Neutron interferometry uniquely combines neutron imaging and scattering methods to enable characterization of multiple length scales from 1 nm to 10 µm. However, building, operating, and using such neutron imaging instruments poses constrai
Externí odkaz:
https://doaj.org/article/148b8ee530314312bd97d19607a30519
Autor:
Arya Y Nakhe, Prasanna K Dadi, Jinsun Kim, Matthew T Dickerson, Soma Behera, Jordyn R Dobson, Shristi Shrestha, Jean-Philippe Cartailler, Leesa Sampson, Mark A Magnuson, David A Jacobson
Publikováno v:
eLife, Vol 12 (2024)
The gain-of-function mutation in the TALK-1 K+ channel (p.L114P) is associated with maturity-onset diabetes of the young (MODY). TALK-1 is a key regulator of β-cell electrical activity and glucose-stimulated insulin secretion. The KCNK16 gene encodi
Externí odkaz:
https://doaj.org/article/add61f69979043f080ec8914198063ad
Autor:
Sarah M. Graff, Arya Y. Nakhe, Prasanna K. Dadi, Matthew T. Dickerson, Jordyn R. Dobson, Karolina E. Zaborska, Chloe E. Ibsen, Regan B. Butterworth, Nicholas C. Vierra, David A. Jacobson
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113673- (2024)
Summary: Mitochondrial Ca2+ ([Ca2+]m) homeostasis is critical for β-cell function and becomes disrupted during the pathogenesis of diabetes. [Ca2+]m uptake is dependent on elevations in cytoplasmic Ca2+ ([Ca2+]c) and endoplasmic reticulum Ca2+ ([Ca2
Externí odkaz:
https://doaj.org/article/bafc4693a1fb4df690f3a63ad1e180e7
Autor:
Jordyn R. Dobson, David A. Jacobson
Publikováno v:
Biology, Vol 13, Iss 6, p 379 (2024)
The β-cell workload increases in the setting of insulin resistance and reduced β-cell mass, which occurs in type 2 and type 1 diabetes, respectively. The prolonged elevation of insulin production and secretion during the pathogenesis of diabetes re
Externí odkaz:
https://doaj.org/article/f836267799244632a50c12fa6480f4c7
Autor:
Susan R. Leonard, Mark K. Mammel, Sonia Almeria, Solomon T. Gebru, David K. Jacobson, Anna C. Peterson, Joel L. N. Barratt, Steven M. Musser
Publikováno v:
Microorganisms, Vol 12, Iss 5, p 848 (2024)
Cyclospora cayetanensis is a foodborne parasite that causes cyclosporiasis, an enteric illness in humans. Genotyping methods are used to genetically discriminate between specimens from cyclosporiasis cases and can complement source attribution invest
Externí odkaz:
https://doaj.org/article/3f3bd05d9817403dbe373dfe766244fa
Autor:
Matthew T. Dickerson, Prasanna K. Dadi, Karolina E. Zaborska, Arya Y. Nakhe, Charles M. Schaub, Jordyn R. Dobson, Nicole M. Wright, Joshua C. Lynch, Claire F. Scott, Logan D. Robinson, David A. Jacobson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Gi/o protein-coupled receptors (Gi/o-GPCRs) limit β-cell insulin secretion by decreasing Ca2+ entry; however, the underlying mechanism has not been identified. Here, the authors show that Gi/o-GPCRs hyperpolarize mouse and human β-cell membrane pot
Externí odkaz:
https://doaj.org/article/eb23a693600e41d29543c852619dfa62
Publikováno v:
Current Research in Parasitology and Vector-Borne Diseases, Vol 4, Iss , Pp 100145- (2023)
Human-infecting Cyclospora was recently characterized as three species, two of which (C. cayetanensis and C. ashfordi) are currently responsible for all known human infections in the USA, yet much remains unknown about the genetic structure within th
Externí odkaz:
https://doaj.org/article/72a8316fc2cd48428d6c3536322e52df
Autor:
Joanna McFarlane, Victoria H. DiStefano, Philip R. Bingham, Hassina Z. Bilheux, Michael C. Cheshire, Richard E. Hale, Daniel S. Hussey, David L. Jacobson, Lindsay Kolbus, Jacob M. LaManna, Edmund Perfect, Mark Rivers, Louis J. Santodonato, Lawrence M. Anovitz
Publikováno v:
ACS Omega, Vol 6, Iss 48, Pp 32618-32630 (2021)
Externí odkaz:
https://doaj.org/article/6b9b2c3652744280b58ae901d6b2b2a7
Autor:
David M. Jacobson
Publikováno v:
Electrum (2022)
Without having any contemporaneous account of the Bar Kokhba Revolt comparable to the writings of Josephus that describe the First Jewish Revolt, our knowledge about many aspects of the later uprising is rather sketchy. The publication of Roman milit
Externí odkaz:
https://doaj.org/article/35ff1be73ee443168c0d2d69745dcdb8
Autor:
Kishan Bellur, Ezequiel F. Medici, Daniel S. Hussey, David L. Jacobson, Jacob LaManna, Juscelino B. Leao, Julia Scherschligt, James C Hermanson, Chang Kyoung Choi, Jeffrey S. Allen
Publikováno v:
Data in Brief, Vol 43, Iss , Pp 108474- (2022)
Cryogenic Propellant management is a critical roadblock to enable long term space missions. Commonly used propellants (liquid hydrogen and methane) undergo constant vaporization but there is limited knowledge on the phase change rate and its implicat
Externí odkaz:
https://doaj.org/article/aa7cb7e56ae444b6a4b9b8197e2fdf98