Zobrazeno 1 - 10
of 56
pro vyhledávání: '"David P. Humphreys"'
Autor:
Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, Anthony Shock
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTRozanolixizumab is a humanized anti-neonatal Fc receptor (FcRn) monoclonal antibody (mAb) of the immunoglobulin G4 (IgG4) sub-class, currently in clinical development for the treatment of IgG autoantibody-driven diseases. This format is frequ
Externí odkaz:
https://doaj.org/article/f74b0a47f067425f9e3ed7abc893041a
Autor:
Emma Davé, Oliver Durrant, Neha Dhami, Joanne Compson, Janice Broadbridge, Sophie Archer, Asher Maroof, Kevin Whale, Karelle Menochet, Pierre Bonnaillie, Emily Barry, Gavin Wild, Claude Peerboom, Pallavi Bhatta, Mark Ellis, Matthew Hinchliffe, David P. Humphreys, Sam P. Heywood
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTTrYbe® is an Fc-free therapeutic antibody format, capable of engaging up to three targets simultaneously, with long in vivo half-life conferred by albumin binding. This format is shown by small-angle X-ray scattering to be conformationally f
Externí odkaz:
https://doaj.org/article/da5a5f25917d459295f40b2ca83010e7
Autor:
Joshua M. Sopp, Shirley J. Peters, Tania F. Rowley, Robert J. Oldham, Sonya James, Ian Mockridge, Ruth R. French, Alison Turner, Stephen A. Beers, David P. Humphreys, Mark S. Cragg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Sopp et al describe an approach, which exploits the tailpiece of the naturally multimeric IgM to augment hexamerisation of IgG. Their approach provides a newly engineered format of antibodies for promoting hexamerisation and enhanced complement-depen
Externí odkaz:
https://doaj.org/article/26ae9b2bf9f1415f9ed90dfd8fef8201
Autor:
Khiyam Hussain, Chantal E. Hargreaves, Tania F. Rowley, Joshua M. Sopp, Kate V. Latham, Pallavi Bhatta, John Sherington, Rona M. Cutler, David P. Humphreys, Martin J. Glennie, Jonathan C. Strefford, Mark S. Cragg
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Monoclonal antibody (mAb) immunotherapy has transformed the treatment of allergy, autoimmunity, and cancer. The interaction of mAb with Fc gamma receptors (FcγR) is often critical for efficacy. The genes encoding the low-affinity FcγR have single n
Externí odkaz:
https://doaj.org/article/6395b221ff5b495993308829d817aa61
Autor:
Pallavi Bhatta, David P. Humphreys
Publikováno v:
Antibodies, Vol 7, Iss 3, p 35 (2018)
Bispecific antibodies represent an emerging class of antibody drugs that are commonly generated by fusion of Fv or scFv antigen binding domains to IgG or Fab scaffolds. Fv- or scFv-mediated multimerisation of bispecific antibodies via promiscuous vH-
Externí odkaz:
https://doaj.org/article/6f97f7ab75634c70a1c9f843308e4c7c
Autor:
Jennifer Cable, Erica Ollmann Saphire, Adrian C. Hayday, Timothy D. Wiltshire, Jarrod J. Mousa, David P. Humphreys, Esther C. W. Breij, Pierre Bruhns, Matteo Broketa, Genta Furuya, Blake M. Hauser, Matthieu Mahévas, Andrea Carfi, Tineke Cantaert, Peter D. Kwong, Prabhanshu Tripathi, Jonathan H. Davis, Neil Brewis, Bruce A. Keyt, Felix L. Fennemann, Vincent Dussupt, Arvind Sivasubramanian, Philip M. Kim, Reda Rawi, Eve Richardson, Daniel Leventhal, Rachael M. Wolters, Cecile A. W. Geuijen, Matthew A. Sleeman, Niccolo Pengo, Francesca Rose Donnellan
Publikováno v:
Annals of the New York Academy of Sciences. 1519:153-166
Therapeutic antibodies have broad indications across diverse disease states, such as oncology, autoimmune diseases, and infectious diseases. New research continues to identify antibodies with therapeutic potential as well as methods to improve upon e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351a2f61d632111c45e1bd85b269f42a
https://doi.org/10.1111/nyas.14915
https://doi.org/10.1111/nyas.14915
Autor:
Ruth R. French, Shirley Jane Peters, Mark S. Cragg, David P. Humphreys, IC Mockridge, Sonya James, Alison Turner, Robert J. Oldham, Tania F. Rowley, Stephen A. Beers, Joshua M. Sopp
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
The majority of depleting monoclonal antibody (mAb) drugs elicit responses via Fc-FcγR and Fc-C1q interactions. Optimal C1q interaction is achieved through hexameric Fc:Fc interactions at the target cell surface. Herein is described an approach to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81f70d0586c1d9d75eb7e79e57a4b45
https://doaj.org/article/26ae9b2bf9f1415f9ed90dfd8fef8201
https://doaj.org/article/26ae9b2bf9f1415f9ed90dfd8fef8201
Publikováno v:
Journal of Allergy and Clinical Immunology. 146:492-500
Since the first description of the administration of high doses of pooled serum IgG, also referred to as intravenous IgG (IVIg) therapy, as being able to ameliorate various autoimmune diseases, researchers have been investigating which molecular and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948a3761bdde632aaed8466b6c53f1d8
https://doi.org/10.1016/j.jaci.2020.06.036
https://doi.org/10.1016/j.jaci.2020.06.036
Autor:
Oliver Zaccheo, Hanna Hailu, Shirley Jane Peters, Frank R. Brennan, Eleanor J. Ward, Rona M. Cutler, Andrew M. Ventom, Nicola L. Davies, David P. Humphreys, Farnaz Fallah-Arani, Thomas L. Pither, Tania F. Rowley, Gianluca Fossati, Louise J. Healy, Joshua M. Sopp, Mike Aylott, Katharine Cain, Alison Eddleston, John Sherington, Robert J. Griffin
Publikováno v:
Communications Biology, Vol 1, Iss 1, Pp 1-12 (2018)
Autoantibody-mediated diseases are currently treated with intravenous immunoglobulin, which is thought to act in part via blockade of Fc gamma receptors, thereby inhibiting autoantibody effector functions and subsequent pathology. We aimed to develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5549f806a17d958b41fae45c108dfc14
http://link.springer.com/article/10.1038/s42003-018-0149-9
http://link.springer.com/article/10.1038/s42003-018-0149-9
Publikováno v:
Journal of Immunological Methods. 454:32-39
Immune complex (IC) deposition of IgG containing autologous antigens has been observed in autoimmunity. This can lead to IC-mediated antigen uptake and presentation by antigen presenting cells (APC) driving T cell dependent inflammation. IgG receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaa4c2010f5b7c46e0a708d43b19ec5
https://doi.org/10.1016/j.jim.2017.12.002
https://doi.org/10.1016/j.jim.2017.12.002