Zobrazeno 1 - 10
of 99
pro vyhledávání: '"David P. Hornby"'
Autor:
Maryam M. Matin, David P. Hornby
Publikováno v:
Journal of Cell and Molecular Research, Vol 11, Iss 2, Pp 55-58 (2020)
We have developed a rapid, quantitative method for analysing the outcome of the first strand synthesis step in cDNA library preparation, yield and molecular weight range of the final cDNA products are determined after size fractionation. This method
Externí odkaz:
https://doaj.org/article/2d9797e5c9e0431d8e18e33d41d4887d
Autor:
Oliver T. Carnell, Nikolay Zenkin, William L. Kelley, Bohdan Bilyk, Jeffrey Green, Viralkumar V. Panchal, Simon J. Foster, Jamie K. Hobbs, Joshua A. F. Sutton, Hamed Mosaei, David P. Hornby, Caitlin Griffiths
Publikováno v:
PLoS Pathogens
PLOS Pathogens, Vol. 16, No 7 (2020) P. e1008672
PLoS Pathogens, Vol 16, Iss 7, p e1008672 (2020)
PLOS Pathogens, Vol. 16, No 7 (2020) P. e1008672
PLoS Pathogens, Vol 16, Iss 7, p e1008672 (2020)
Most clinical MRSA (methicillin-resistant S. aureus) isolates exhibit low-level β-lactam resistance (oxacillin MIC 2–4 μg/ml) due to the acquisition of a novel penicillin binding protein (PBP2A), encoded by mecA. However, strains can evolve high-
Autor:
James Florence, Qaiser I. Sheikh, Yueh Ting Lu, Samir Al Harbi, Paul J. Hurd, Laila Alfageih, Maryam Moghaddam Matin, A M Al-Swailem, Abdulaziz Bin-Dukhyil, Asma Abdalgelel, Adel Al-Ghanim, David P. Hornby, Paul E. Brown, Mohammed Al-Shemirti
The controlled formation of sequence specific DNA protein complexes is a fundamental feature of most genetic transactions. Studies of the impact of point mutations on the function of individual components, such as repressors, remains a key aspect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0cdbccb05a3d1f6d0ee9664595844c
https://doi.org/10.1101/2020.03.09.983320
https://doi.org/10.1101/2020.03.09.983320
Publikováno v:
Molecules, Vol 17, Iss 10, Pp 12086-12101 (2012)
Molecules
Volume 17
Issue 10
Pages 12086-12101
Molecules
Volume 17
Issue 10
Pages 12086-12101
Recent genetic studies have shown that PCSK9, one of the key genes in cholesterol metabolism, plays a critical role by controlling the level of low-density lipoprotein receptor. However, how PCSK9 mediates LDLR degradation is still unknown. By combin
Publikováno v:
Molecules, Vol 17, Iss 1, Pp 796-808 (2012)
Molecules; Volume 17; Issue 1; Pages: 796-808
Molecules
Molecules; Volume 17; Issue 1; Pages: 796-808
Molecules
Semiconductor quantum dots (Qdots) have recently been shown to offer significant advantages over conventional fluorescent probes to image and study biological processes. The stability and low toxicity of QDs are well suited for biological application
Autor:
David P. Hornby
Publikováno v:
The Biochemist. 39:51
Autor:
Guillaume M. Hautbergue, Paul J. Hurd, Alex Bloom, Helen L. Phillips, Mark J. Dickman, Ambrosius P. Snijders, David P. Hornby, Thomas C. Minshull, Simeon R. Mihaylov, Douglas T. Gjerde, Stuart A. Wilson, James C. Williamson
Publikováno v:
RNA (New York, N.Y.). 21(3)
Splicing factor proline- and glutamine-rich (SFPQ) also commonly known as polypyrimidine tract-binding protein-associated-splicing factor (PSF) and its binding partner non-POU domain-containing octamer-binding protein (NONO/p54nrb), are highly abunda
Autor:
Mark J. Dickman, David P. Hornby
Publikováno v:
RNA. 12:691-696
Here we describe a procedure for the rapid enrichment of RNA from cell extracts and the subsequent fractionation and analysis of the “small RNA” population by ion pair reverse phase chromatography. Solid phase extraction procedures have been deve
Publikováno v:
Journal of Biochemical and Biophysical Methods. 58:39-48
The RuvABC resolvasome of Escherichia coli typifies nucleoprotein complexes involved in genetic transactions. This molecular assembly catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. This process
Autor:
Victoria H. Harris, Alan L. Hamilton, David M. Williams, W. Jonathan Cummins, David P. Hornby, Clifford Smith
Publikováno v:
Org. Biomol. Chem.. 1:2070-2074
The highly mutagenic nucleoside dP (6-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4-dihydro-6H,8H-pyrimido[4,5-c][1,2]oxazin-2-one) is a bicyclic analogue of N4-methoxy-2'-deoxycytidine. It exists as a mixture of its imino and amino tautomers in soluti