Zobrazeno 1 - 10
of 176
pro vyhledávání: '"David P. Hajjar"'
Autor:
Ying Liu, Zhuo Wei, Xingzhe Ma, Xiaoxiao Yang, Yuanli Chen, Lei Sun, Chuanrui Ma, Qing R. Miao, David P. Hajjar, Jihong Han, Yajun Duan
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 439-451 (2018)
Cholesterol 25-hydroxylase (CH25H) catalyzes the production of 25-hydroxycholesterol (25-HC), an oxysterol that can play an important role in different biological processes. However, the mechanisms regulating CH25H expression have not been fully eluc
Externí odkaz:
https://doaj.org/article/7a35415dcb4345548725178c11011f23
Autor:
Ruba S. Deeb, Gang Hao, Steven S. Gross, Muriel Laineé, Ju Hua Qiu, Brad Resnick, Elisar J. Barbar, David P. Hajjar, Rita K. Upmacis
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 5, Pp 898-911 (2006)
The mechanism by which the inflammatory enzyme prostaglandin H2 synthase-1 (PGHS-1) deactivates remains undefined. This study aimed to determine the stabilizing parameters of PGHS-1 and identify factors leading to deactivation by nitric oxide species
Externí odkaz:
https://doaj.org/article/b1388b80843d4688af2a98c165e4df8b
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 10, Pp 1877-1886 (2003)
Adipocyte fatty acid binding protein (aP2) is a key mediator of intracellular transport and metabolism of fatty acids. Its expression during adipocyte differentiation is regulated through the actions of peroxisome proliferator-activated receptor γ (
Externí odkaz:
https://doaj.org/article/423bb47c718745fcb0800d4751ef778d
Autor:
Ruba S. Deeb, Matthew J. Resnick, Dev Mittar, Timothy McCaffrey, David P. Hajjar, Rita K. Upmacis
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 10, Pp 1718-1726 (2002)
In this study, we investigated the effects of various nitrogen oxide (NOx) species on the extent of prostaglandin H2 synthase-1 (PGHS-1) nitration in purified protein and in vascular smooth muscle cells. We also examined PGHS-1 activity under these c
Externí odkaz:
https://doaj.org/article/6da71e16a94645198e8f330e94068e9b
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 5, Pp 830-838 (1999)
CD36, the macrophage type B scavenger receptor, binds and internalizes oxidized low density lipoprotein (OxLDL), and may potentially play a role in the development of atherosclerosis. We reported that the native and modified low density lipoproteins
Externí odkaz:
https://doaj.org/article/ba3c10fd36c54edeb3185c4a6bd3ea09
Autor:
Aaron J. Marcus, David P. Hajjar
Publikováno v:
Journal of Lipid Research, Vol 34, Iss 12, Pp 2017-2031 (1993)
Thus, it is apparent that humoral factors released during inflammation can affect cholesterol metabolism in arterial cells during atherogenesis. These humoral factors released from the macrophage, endothelium, or smooth muscle can modify the cytokine
Externí odkaz:
https://doaj.org/article/0891ef35564f410898cfdb499ee96f86
Autor:
Yajun Duan, Chuanrui Ma, Jihong Han, Derun Kong, Qi Li, Yujue Zhang, Wenquan Hu, Huaqing Hu, Yan Zhu, Zhuo Wei, David P. Hajjar, Qing Robert Miao, Hua Wang, Yuanli Chen, Shuang Zhang, Fangling Guo, Xiaoxiao Yang, Miao Yu, Xiaoju Li
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Intrahepatic cholestasis is mainly caused by dysfunction of bile secretion and has limited effective treatment. Rosiglitazone is a synthetic agonist of PPARγ, whose endogenous agonist is 15‐deoxy‐Δ(12,14)‐PGJ(2) (15d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8dad30a76380edbd6658318d41bc0a7
https://doi.org/10.1111/bph.14886
https://doi.org/10.1111/bph.14886
Publikováno v:
The American Journal of Pathology. 189:492-501
The complex relationship between diet and metabolism is an important contributor to cellular metabolism and health. Over the past few decades, a central role for mammalian target of rapamycin (mTOR) in the regulation of multiple cellular processes, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e632a05c75b2b20aa5aca5481bb8ca1
https://doi.org/10.1016/j.ajpath.2018.11.013
https://doi.org/10.1016/j.ajpath.2018.11.013
Autor:
S. Schwartz, James A. Hamilton, Karel A. Erion, G. Tasik, Nathan E. Burritt, Barbara E. Corkey, N. Huang, J. Bodde, Antonio M. Gotto, K. Sao, C. Sponseller, E. Gajrawala, Elizabeth Anne Kolar, M. Sitaram, David P. Hajjar, Jude T. Deeney
Publikováno v:
Atherosclerosis. 331:e170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e920b9ad2584475370292393d957453
https://doi.org/10.1016/j.atherosclerosis.2021.06.518
https://doi.org/10.1016/j.atherosclerosis.2021.06.518
Autor:
David P. Hajjar, Ruba S. Deeb
Publikováno v:
The American Journal of Pathology. 186:1736-1749
The interplay that governs chronic diseases through pathways specifically associated with chronic inflammation remains undefined. Many metabolic events have been identified during the injury and repair process. Nonetheless, the cellular events that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99e4f618ce1889e7b97c1a05ba8ebfc
https://doi.org/10.1016/j.ajpath.2016.03.001
https://doi.org/10.1016/j.ajpath.2016.03.001