Zobrazeno 1 - 10
of 20
pro vyhledávání: '"David P. Guertin"'
Autor:
Adriana A. Zuniga-Teran, Barron J. Orr, Randy H. Gimblett, Nader V. Chalfoun, Stuart E. Marsh, David P. Guertin, Scott B. Going
Publikováno v:
Frontiers of Architectural Research, Vol 6, Iss 1, Pp 63-73 (2017)
Research from multiple domains has provided insights into how neighborhood design can be improved to have a more favorable effect on physical activity, a concept known as walkability. The relevant research findings/hypotheses have been integrated int
Externí odkaz:
https://doaj.org/article/b143c2e0a3dd40af8470167c1d74737f
Autor:
Adriana A. Zuniga-Teran, Barron J. Orr, Randy H. Gimblett, Nader V. Chalfoun, Scott B. Going, David P. Guertin, Stuart E. Marsh
Publikováno v:
Frontiers of Architectural Research, Vol 5, Iss 4, Pp 433-452 (2016)
Prevailing city design in many countries has created sedentary societies that depend on automobile use. Consequently, architects, urban designers, and land planners have developed new urban design theories, which have been incorporated into the Leade
Externí odkaz:
https://doaj.org/article/ea505556b88846418d820373450643c9
Autor:
Nuria Martinez, Catherine Y. Cheng, Natkunam Ketheesan, Aidan Cullen, Yuefeng Tang, Josephine Lum, Kim West, Michael Poidinger, David A. Guertin, Amit Singhal, Hardy Kornfeld
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 314-327 (2019)
Background: Mycobacterium tuberculosis has co-evolved with the human host, adapting to exploit the immune system for persistence and transmission. While immunity to tuberculosis (TB) has been intensively studied in the lung and lymphoid system, littl
Externí odkaz:
https://doaj.org/article/d7e6f9f991b54091830661097d95a4ef
Publikováno v:
Molecular Metabolism, Vol 23, Iss , Pp 60-74 (2019)
Objective: Understanding the signaling mechanisms that control brown adipose tissue (BAT) development is relevant to understanding energy homeostasis and obesity. The AKT kinases are insulin effectors with critical in vivo functions in adipocytes; ho
Externí odkaz:
https://doaj.org/article/e82e5aa598154a1f86c7f650aaf996df
Autor:
Wen-Yu Hsiao, Su Myung Jung, Yuefeng Tang, John A. Haley, Rui Li, Huawei Li, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Chien-Min Hung, Amelia K. Luciano, Victoria DeMambro, Kathryn E. Wellen, Clifford J. Rosen, Lihua Julie Zhu, David A. Guertin
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108223- (2020)
Summary: Overweight and obesity are associated with type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular disease and cancer, but all fat is not equal, as storing excess lipid in subcutaneous white adipose tissue (SWAT) is more metabolic
Externí odkaz:
https://doaj.org/article/ebbfe315580b43abaa7443bebda88fd8
Publikováno v:
International Soil and Water Conservation Research. 10:177-187
Hydrologic response in a watershed is driven by precipitation. Multi-site rainfall generators can be used to model watersheds using spatially varied rainfall inputs to better analyze how the rainfall variability affects runoff generation. This study
Autor:
Sully Fernandez, John M. Viola, AnnMarie Torres, Martina Wallace, Sophie Trefely, Steven Zhao, Hayley C. Affronti, Jivani M. Gengatharan, David A. Guertin, Nathaniel W. Snyder, Christian M. Metallo, Kathryn E. Wellen
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2772-2784.e6 (2019)
Summary: Sugars and refined carbohydrates are major components of the modern diet. ATP-citrate lyase (ACLY) is upregulated in adipocytes in response to carbohydrate consumption and generates acetyl-coenzyme A (CoA) for both lipid synthesis and acetyl
Externí odkaz:
https://doaj.org/article/b1e97b77b6bb47a5b16ec6174ac70f5c
Publikováno v:
Molecular Metabolism, Vol 5, Iss 6, Pp 422-432 (2016)
Objective: Normal adipose tissue growth and function is critical to maintaining metabolic homeostasis and its excess (e.g. obesity) or absence (e.g. lipodystrophy) is associated with severe metabolic disease. The goal of this study was to understand
Externí odkaz:
https://doaj.org/article/952396a00d2245e0b1193e3419f3526b
Autor:
Yuefeng Tang, Martina Wallace, Joan Sanchez-Gurmaches, Wen-Yu Hsiao, Huawei Li, Peter L. Lee, Santiago Vernia, Christian M. Metallo, David A. Guertin
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The kinase mTOR controls anabolic metabolism. Here, the authors create fat-specific mTORC2 knockout mice using the Adiponectin-Cre driver and show mTORC2 signalling is important for systemic metabolic homeostasis by controlling adipocyte de novolipog
Externí odkaz:
https://doaj.org/article/8b210ace86684fa9b926e0715133be0a
Publikováno v:
Stem Cell Reports, Vol 4, Iss 4, Pp 541-550 (2015)
The origins of individual fat depots are not well understood, and thus, the availability of tools useful for studying depot-specific adipose tissue development and function is limited. Cre drivers that selectively target only brown adipocyte, subcuta
Externí odkaz:
https://doaj.org/article/a26405374b714d5abe7047b7bb26ba86