Zobrazeno 1 - 10
of 36
pro vyhledávání: '"David P. Glass"'
Autor:
Jason S. Wasserman, Bulat Faezov, Kishan R. Patel, Alison M. Kurimchak, Seren M. Palacio, David J. Glass, Holly Fowle, Brennan C. McEwan, Qifang Xu, Ziran Zhao, Lauren Cressey, Neil Johnson, James S. Duncan, Arminja N. Kettenbach, Roland L. Dunbrack, Xavier Graña
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The Ser/Thr protein phosphatase 2 A (PP2A) regulates the dephosphorylation of many phosphoproteins. Substrate recognition are mediated by B regulatory subunits. Here, we report the identification of a substrate conserved motif [RK]-V-x-x-[VI
Externí odkaz:
https://doaj.org/article/6e9017a5c5d34b82817862a82164f6a6
Autor:
YeEun Kim, Ariel A. Calderon, Patricia Favaro, David R. Glass, Albert G. Tsai, Daniel Ho, Luciene Borges, William J. Greenleaf, Sean C. Bendall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Lymphoid specification in human hematopoietic progenitors is not fully understood. To better associate lymphoid identity with protein-level cell features, we conduct a highly multiplexed single-cell proteomic screen on human bone marrow prog
Externí odkaz:
https://doaj.org/article/051d1acc4a3e494b86aac1b487e294fc
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110625- (2024)
Summary: Endocrine glands secrete hormones into the circulation to target distant tissues and regulate their functions. The qualitative relationship between hormone-secreting organs and their target tissues is well established, but a quantitative app
Externí odkaz:
https://doaj.org/article/884e19eba5b0471aaaa2a3147f1588cb
Autor:
John J. Krais, David J. Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson, Pooja Patel, Zemin Liu, Ryan Neumann-Domer, Robert G. Betsch, Andrea J. Bernhardy, Alice M. Bradbury, Jason Conger, Wei-Ting Yueh, Joseph Nacson, Richard T. Pomerantz, Gaorav P. Gupta, Joseph R. Testa, Neil Johnson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Homologous recombination (HR)-deficiency induces a dependency on DNA polymerase theta (Polθ/Polq)-mediated end joining, and Polθ inhibitors (Polθi) are in development for cancer therapy. BRCA1 and BRCA2 deficient cells are thought to be s
Externí odkaz:
https://doaj.org/article/1134d3c423c24ee9b10823404374aee9
Autor:
Tea Shavlakadze, Kun Xiong, Shawn Mishra, Corissa McEwen, Abhilash Gadi, Matthew Wakai, Hunter Salmon, Michael J. Stec, Nicole Negron, Min Ni, Yi Wei, Gurinder S. Atwal, Yu Bai, David J. Glass
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakness is known as “sarcopenia”. Sarcopenia is part of the frailty observed in humans. In order to discover
Externí odkaz:
https://doaj.org/article/a43926fa120c4d5db9e644d5c5986045
Autor:
Neil Johns, Shinji Hatakeyama, Nathan A Stephens, Martin Degen, Simone Degen, Wilfried Frieauff, Christian Lambert, James A Ross, Ronenn Roubenoff, David J Glass, Carsten Jacobi, Kenneth C H Fearon, PLOS ONE Editors
Publikováno v:
PLoS ONE, Vol 19, Iss 12, p e0314953 (2024)
[This corrects the article DOI: 10.1371/journal.pone.0083618.].
Externí odkaz:
https://doaj.org/article/d9358f7d2f0148d5a1b74062c8bdf0b8
Autor:
Dana J. Murdock, Ning Wu, Joseph S. Grimsby, Roberto A. Calle, Stephen Donahue, David J. Glass, Mark W. Sleeman, Robert J. Sanchez
Publikováno v:
Skeletal Muscle, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Background Sarcopenia is defined as age-related low muscle mass and function, and can also describe the loss of muscle mass in certain medical conditions, such as sarcopenic obesity. Sarcopenic obesity describes loss of muscle and function i
Externí odkaz:
https://doaj.org/article/4f56a81b31534134b1d3d6277a01fa08
Autor:
Marco S. Kaiser, Giulia Milan, Daniel J. Ham, Shuo Lin, Filippo Oliveri, Kathrin Chojnowska, Lionel A. Tintignac, Nitish Mittal, Christian E. Zimmerli, David J. Glass, Mihaela Zavolan, Markus A. Rüegg
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Exploring the relationship between mTORC1 and the ubiquitin-proteasome system, light is shed on the paradox between mTORC1-mediated muscle hypertrophy induced by PKB/Akt and the muscle atrophy induced by mTORC1 alone.
Externí odkaz:
https://doaj.org/article/f20a08691add485199dd53a06c8fd523
Autor:
Celestine N. Wanjalla, Curtis L. Gabriel, Hubaida Fuseini, Samuel S. Bailin, Mona Mashayekhi, Joshua Simmons, Christopher M. Warren, David R. Glass, Jared Oakes, Rama Gangula, Erin Wilfong, Stephen Priest, Tecla Temu, Evan W. Newell, Suman Pakala, Spyros A. Kalams, Sara Gianella, David Smith, David G. Harrison, Simon A. Mallal, John R. Koethe
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Persons with HIV (PWH) on long-term antiretroviral therapy (ART) have a higher incidence and prevalence of cardiometabolic diseases attributed, in part, to persistent inflammation despite viral suppression. In addition to traditional risk factors, im
Externí odkaz:
https://doaj.org/article/2838cff8bda74656ae8136d9ff338554
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Network motif models focus on small sub-networks in biological systems to quantitatively describe overall behavior but they often overlook time delays. Here, the authors systematically examine the most common network motifs via delay differential equ
Externí odkaz:
https://doaj.org/article/aba959ab8e8b4d49bc6ed53854e3b5b3