Zobrazeno 1 - 10
of 233
pro vyhledávání: '"David P. Giedroc"'
Autor:
Claire C. Mammoser, Brynn E. LeMasters, Sydney G. Edwards, Emma M. McRae, M. Hunter Mullins, Yiqi Wang, Nicholas M. Garcia, Katherine A. Edmonds, David P. Giedroc, Megan C. Thielges
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Blue copper proteins are models for illustrating how proteins tune metal properties. Nevertheless, the mechanisms by which the protein controls the metal site remain to be fully elucidated. A hindrance is that the closed shell Cu(I) site is
Externí odkaz:
https://doaj.org/article/f73a1aa8abd44131a24ab020e3fde38c
Autor:
Yifan Zhang, Giovanni Gonzalez-Gutierrez, Katherine A. Legg, Brenna J. C. Walsh, Cristian M. Pis Diez, Katherine A. Edmonds, David P. Giedroc
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The extent to which human bacterial pathogens broadly utilize ergothioneine as an antioxidant is unknown. Here, authors describe the discovery of a specific transporter for ergothioneine in a respiratory pathogen that is highly conserved among Firmic
Externí odkaz:
https://doaj.org/article/020e1d9700b54130b84870a80838af9c
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101424- (2022)
Summary: Hydrogen sulfide (H2S) and downstream reactive sulfur species (RSS), including organic persulfides, protect bacterial cells against diverse oxidative stressors. Specialized dithiol-based transcriptional repressors sense persulfides directly
Externí odkaz:
https://doaj.org/article/8f6ecb79ca6e465091356e7a4bf81337
Autor:
Brenna J. C. Walsh, Sofia Soares Costa, Katherine A. Edmonds, Jonathan C. Trinidad, Federico M. Issoglio, José A. Brito, David P. Giedroc
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1607 (2022)
Hydrogen sulfide (H2S) is implicated as a cytoprotective agent that bacteria employ in response to host-induced stressors, such as oxidative stress and antibiotics. The physiological benefits often attributed to H2S, however, are likely a result of d
Externí odkaz:
https://doaj.org/article/b80dede8359641e39486f883ee6e0b87
Autor:
Brenna J. C. Walsh, Jiefei Wang, Katherine A. Edmonds, Lauren D. Palmer, Yixiang Zhang, Jonathan C. Trinidad, Eric P. Skaar, David P. Giedroc
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Acinetobacter baumannii is an opportunistic nosocomial pathogen that is the causative agent of several serious infections in humans, including pneumonia, sepsis, and wound and burn infections. A. baumannii is also capable of forming proteina
Externí odkaz:
https://doaj.org/article/9c05a8f948d04b15b84e77a4280b07b8
Autor:
Britta E. Rued, Martín Alcorlo, Katherine A. Edmonds, Siseth Martínez-Caballero, Daniel Straume, Yue Fu, Kevin E. Bruce, Hongwei Wu, Leiv S. Håvarstein, Juan A. Hermoso, Malcolm E. Winkler, David P. Giedroc
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT Streptococcus pneumoniae is a leading killer of infants and immunocompromised adults and has become increasingly resistant to major antibiotics. Therefore, the development of new antibiotic strategies is desperately needed. Targeting bacteri
Externí odkaz:
https://doaj.org/article/28bda687b8f04f1b9f23af1eaef5cc27
Autor:
Zachery R. Lonergan, Brittany L. Nairn, Jiefei Wang, Yen-Pang Hsu, Laura E. Hesse, William N. Beavers, Walter J. Chazin, Jonathan C. Trinidad, Michael S. VanNieuwenhze, David P. Giedroc, Eric P. Skaar
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2009-2018.e6 (2019)
Summary: Acinetobacter baumannii is an important nosocomial pathogen capable of causing wound infections, pneumonia, and bacteremia. During infection, A. baumannii must acquire Zn to survive and colonize the host. Vertebrates have evolved mechanisms
Externí odkaz:
https://doaj.org/article/20909d2dfa1a429390eb5ab0218db2a6
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Hydrogen sulfide (H2S) is thought to signal through protein S-sulfuration (persulfidation; S-sulfhydration) in both mammalian systems and bacteria. We previously profiled proteome S-sulfuration in Staphylococcus aureus (S. aureus) and identified two
Externí odkaz:
https://doaj.org/article/83b25c1230464ee28475cc8fde7b0f4f
Autor:
Hui Peng, Jiangchuan Shen, Katherine A. Edmonds, Justin L. Luebke, Anne K. Hickey, Lauren D. Palmer, Feng-Ming James Chang, Kevin A. Bruce, Thomas E. Kehl-Fie, Eric P. Skaar, David P. Giedroc
Publikováno v:
mSphere, Vol 2, Iss 3 (2017)
ABSTRACT Staphylococcus aureus is a commensal human pathogen and a major cause of nosocomial infections. As gaseous signaling molecules, endogenous hydrogen sulfide (H2S) and nitric oxide (NO·) protect S. aureus from antibiotic stress synergisticall
Externí odkaz:
https://doaj.org/article/60c8556789154f8cabe92ef3914e72d7
Autor:
John P. Lisher, Ho-Ching Tiffany Tsui, Smirla Ramos-Montañez, Kristy L. Hentchel, Julia E. Martin, Jonathan C. Trinidad, Malcolm E. Winkler, David P. Giedroc
Publikováno v:
mSphere, Vol 2, Iss 1 (2017)
ABSTRACT The catalase-negative, facultative anaerobe Streptococcus pneumoniae D39 is naturally resistant to hydrogen peroxide (H2O2) produced endogenously by pyruvate oxidase (SpxB). Here, we investigate the adaptive response to endogenously produced
Externí odkaz:
https://doaj.org/article/9b263744cdb6477bb91a837cfbe40d8f