Výsledky vyhledávání - "David P. Gearing"

A Feline‐Specific Anti‐Nerve Growth Factor Antibody Improves Mobility in Cats with Degenerative Joint Disease–Associated Pain: A Pilot Proof of Concept Study

Autor: David P. Gearing, Andrea Thomson, Margaret E. Gruen, B.D.X. Lascelles, Emily H. Griffith, Hayley Paradise

Publikováno v: Journal of Veterinary Internal Medicine

Background Neutralizing antibodies against nerve growth factor (NGF) are analgesic in rodent models, naturally occurring degenerative joint disease (DJD) pain in dogs, and chronic pain in humans. Objectives To evaluate the efficacy of a fully feliniz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0138415698852f9a74f0a897e472680
http://europepmc.org/articles/PMC5153962

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In Vitro and In Vivo Characterization of a Fully Felinized Therapeutic Anti‐Nerve Growth Factor Monoclonal Antibody for the Treatment of Pain in Cats

Autor: Alexander Charles Drew, R.P. Gearing, E.R. Virtue, David P. Gearing, K. Knight, Per Hansen, B.D.X. Lascelles, M. Huebner

Publikováno v: Journal of Veterinary Internal Medicine

Background Limited options are available for the treatment of pain in cats. Monoclonal antibodies (mAbs) that neutralize nerve growth factor (NGF) have demonstrated analgesic capacity in rodent models, people with osteoarthritis, and dogs with degene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4493b2ac7f0d4b430768555378d381d7
http://europepmc.org/articles/PMC5094543

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A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain

Autor: David P. Gearing, John F. Innes, David Knazovicky, B. Duncan X. Lascelles, Alexander Charles Drew, Mila Freire, Beth Case

Publikováno v: BMC Veterinary Research

Background There is a critical need for proven drugs other than non-steroidal anti-inflammatory drugs for treatment of degenerative joint disease (DJD) pain in dogs. Antibodies against nerve growth factor (NGF) are analgesic in rodent models and in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173f088d4680f527607bfdcf8b6809ab
https://doi.org/10.1186/s12917-015-0413-x

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High-Resolution Structure of Murine Interleukin 1 Homologue IL-1F5 Reveals Unique Loop Conformations for Receptor Binding Specificity

Autor: Eleanor F. Dunn, Nicholas J. Gay, Adrian F. Bristow, David P. Gearing, Luke A. J. O'Neill, Xue Yuan Pei

Publikováno v: Biochemistry. 42:10938-10944

Interleukin-1 (IL-1) F5 is a novel member of the IL-1 family. The IL-1 family are involved in innate immune responses to infection and injury. These cytokines bind to specific receptors and cause activation of NFkappaB and MAP kinase. IL-1F5 has a se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464e2754d29cf7034918968f1dec018e
https://doi.org/10.1021/bi0341197

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Canine Brief Pain Inventory scores for dogs with osteoarthritis before and after administration of a monoclonal antibody against nerve growth factor

Autor: David P. Gearing, Gail I. Anderson, Ralph P. Webster

Publikováno v: American journal of veterinary research. 75(6)

Objective—To determine changes in Canine Brief Pain Inventory scores for dogs with osteoarthritis after administration of a monoclonal antibody (mAb) against nerve growth factor (NGF) that was modified by use of a proprietary process for administra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73f1fb99063fc317bcb0d6a07e477c6
https://pubmed.ncbi.nlm.nih.gov/24866508

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Twisted gastrulation can function as a BMP antagonist

Autor: David P. Gearing, William E. Holmes, Jana Bodorova, Lisa Holmgren, Chenbei Chang, Samantha Chau, Elizabeth A. Woolf, Ali H. Brivanlou, Douglas A. Holtzman, Troy Chickering

Publikováno v: Nature. 410:483-487

Bone morphogenetic proteins (BMPs), including the fly homologue Decapentaplegic (DPP), are important regulators of early vertebrate and invertebrate dorsal–ventral development1,2,3,4,5,6. An evolutionarily conserved BMP regulatory mechanism operate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09530d1c70460e6522ac94616a70a2fa
https://doi.org/10.1038/35068583

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Characterization of a Neuregulin-Related Gene, Don-1, That Is Highly Expressed in Restricted Regions of the Cerebellum and Hippocampus

Autor: Christopher A. Comrack, Andrew D. J. Goodearl, Jessica Woolf, Samantha J. Busfield, Tracy L. Revett, Donna A. Michnick, David P. Gearing, Barry J. Dussault, Jingya Ma, Elizabeth A. Woolf, Troy Chickering

Publikováno v: Molecular and Cellular Biology. 17:4007-4014

Members of the epidermal growth factor family of receptors have long been implicated in the pathogenesis of various tumors, and more recently, apparent roles in the developing heart and nervous system have been described. Numerous ligands that activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40cbd56bc9c5a0c0d22d3d290fe4b92
https://doi.org/10.1128/mcb.17.7.4007

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Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

Autor: Barry J. Dussault, Hong Zhou, Janice A. Culpepper, Jim Deeds, David P. Gearing, Jose-Carlos Gutierrez-Ramos, Mike L. Gosselin, Jim Vath, Clare M. Lloyd, Sylvia Dolich, Jose-Angel Gonzalo, Elizabeth A. Woolf, Yang Pan, Geoff Alperin, Jingya Ma

Publikováno v: Nature. 387:611-617

Chemokines are small secreted proteins that stimulate the directional migration of leukocytes and mediate inflammation. During screening of a murine choroid plexus complementary DNA library, we identified a new chemokine, designated neurotactin. Unli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb27a82f221f1486bda48da3eedefb7b
https://doi.org/10.1038/42491

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Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells

Autor: Weiyu Lin, Ronald Hoffman, Ann Tsukamoto, Kevin R. Leiby, David P. Gearing, Stephen J. Szilvassy, Arun K. Sharma, Kevin P. Weller, Alice S.Y. Ho

Publikováno v: Blood. 87:4618-4628

Attempts to maintain or expand primitive hematopoietic stem cells in vitro without the concomitant loss of their differentiative and proliferative potential in vivo have largely been unsuccessful. To investigate this problem, we compared the ability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6dff35f4c31ea40d83ad111500666fad
https://doi.org/10.1182/blood.v87.11.4618.bloodjournal87114618

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