Zobrazeno 1 - 10
of 113
pro vyhledávání: '"David P. Fewer"'
Autor:
Lassi Matti Petteri Heinilä, David P. Fewer, Jouni Kalevi Jokela, Matti Wahlsten, Anna Jortikka, Kaarina Sivonen
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Cyanobacteria produce a wide range of lipopeptides that exhibit potent membrane-disrupting activities. Laxaphycins consist of two families of structurally distinct macrocyclic lipopeptides that act in a synergistic manner to produce antifungal and an
Externí odkaz:
https://doaj.org/article/5fd067d827154c9a8051306a5641dcf0
Publikováno v:
Marine Drugs, Vol 19, Iss 6, p 298 (2021)
Sponges form symbiotic relationships with diverse and abundant microbial communities. Cyanobacteria are among the most important members of the microbial communities that are associated with sponges. Here, we performed a genus-wide comparative genomi
Externí odkaz:
https://doaj.org/article/7b995f675e49403eb74bcec42c82b6a2
Publikováno v:
Toxins, Vol 12, Iss 4, p 248 (2020)
Cyanobacteria produce an array of toxins that pose serious health risks to humans and animals. The closely related diazotrophic genera, Anabaena, Dolichospermum and Aphanizomenon, frequently form poisonous blooms in lakes and brackish waters around t
Externí odkaz:
https://doaj.org/article/0faf624877d64d67bdd7d6aac57a7121
Autor:
Tania Keiko Shishido, Rafael Vicentini Popin, Jouni Jokela, Matti Wahlsten, Marli Fatima Fiore, David P. Fewer, Lars Herfindal, Kaarina Sivonen
Publikováno v:
Toxins, Vol 12, Iss 1, p 12 (2019)
Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms a
Externí odkaz:
https://doaj.org/article/1bef88250b7147aa97e4314e268ea74f
Autor:
Tânia K. Shishido, Anu Humisto, Jouni Jokela, Liwei Liu, Matti Wahlsten, Anisha Tamrakar, David P. Fewer, Perttu Permi, Ana P. D. Andreote, Marli F. Fiore, Kaarina Sivonen
Publikováno v:
Marine Drugs, Vol 13, Iss 4, Pp 2124-2140 (2015)
Cyanobacteria are photosynthetic prokaryotes found in a range of environments. They are infamous for the production of toxins, as well as bioactive compounds, which exhibit anticancer, antimicrobial and protease inhibition activities. Cyanobacteria p
Externí odkaz:
https://doaj.org/article/9c1620342a61452a883e0759040a9117
Autor:
Jouni Jokela, Lassi M. P. Heinilä, Tânia K. Shishido, Matti Wahlsten, David P. Fewer, Marli F. Fiore, Hao Wang, Esa Haapaniemi, Perttu Permi, Kaarina Sivonen
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Nostoc is a cyanobacterial genus, common in soils and a prolific producer of natural products. This research project aimed to explore and characterize Brazilian cyanobacteria for new bioactive compounds. Here we report the production of hepatotoxins
Externí odkaz:
https://doaj.org/article/65f4729182ed416d9d8a554d3c0f60d7
Autor:
Tânia Keiko Shishido, Jouni Jokela, Anu Humisto, Suvi Suurnäkki, Matti Wahlsten, Danillo O. Alvarenga, Kaarina Sivonen, David P. Fewer
Publikováno v:
Marine Drugs, Vol 17, Iss 5, p 271 (2019)
Microcystins are a family of chemically diverse hepatotoxins produced by distantly related cyanobacteria and are potent inhibitors of eukaryotic protein phosphatases 1 and 2A. Here we provide evidence for the biosynthesis of rare variants of microcys
Externí odkaz:
https://doaj.org/article/b363cc5e8f4441d9835dce78895ea6f9
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 22, Iss 6, Pp 695-702 (2009)
We show that the cyanobacterial symbionts of a tripartite cyanolichen can produce hepatotoxic microcystins in situ. Microcystins were detected with high-performance liquid chromatography mass spectrometry both from cephalodia of the tripartite cyanol
Externí odkaz:
https://doaj.org/article/b9075991e5474c5083087b2cd21c5c90
Autor:
Kumar Saurav, Alessia Caso, Petra Urajová, Pavel Hrouzek, Germana Esposito, Kateřina Delawská, Markéta Macho, Jan Hájek, José Cheel, Subhasish Saha, Petra Divoká, Sila Arsin, Kaarina Sivonen, David P. Fewer, Valeria Costantino
Publikováno v:
ACS Omega. 7:11818-11828
Puwainaphycins (PUW) and minutissamides (MIN) are structurally homologous cyclic lipopeptides that exhibit high structural variability and possess antifungal and cytotoxic activities. While only a minor variation can be found in the amino acid compos
Autor:
Claudia Clemente, Nicholas Johnson, Xiaodan Ouyang, Rafael V. Popin, Sergio Dall'Angelo, Matti Wahlsten, Jouni Jokela, Alessandro Colombano, Brunello Nardone, David P. Fewer, Wael E. Houssen
Publikováno v:
Chemical Communications. 58:12054-12057
Cyanobactins are linear and cyclic post-translationally modified peptides. Here we show that the prenyl-D-Arg-containing autum-nalamide A is a member of the cyanobactin family. Biochemical assays demonstrate that the AutF prenyltransferase targets th