Zobrazeno 1 - 10
of 26
pro vyhledávání: '"David P. Dimasi"'
Autor:
Glyn Chidlow, John P M Wood, Shiwani Sharma, David P Dimasi, Kathryn P Burdon, Robert J Casson, Jamie E Craig
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75067 (2013)
It has recently been shown that there are highly significant associations for common single nucleotide polymorphisms (SNPs) near the CDKN2B-AS1 gene region at the 9p21 locus with primary open angle glaucoma (POAG), a leading cause of irreversible bli
Externí odkaz:
https://doaj.org/article/d6ebf5f55bf541d0b5457a12e13110d7
Autor:
Janey L Wiggs, Alex W Hewitt, Bao Jian Fan, Dan Yi Wang, Dayse R Figueiredo Sena, Colm O'Brien, Anthony Realini, Jamie E Craig, David P Dimasi, David A Mackey, Jonathan L Haines, Louis R Pasquale
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45613 (2012)
BACKGROUND:Loss of vision in glaucoma is due to apoptotic retinal ganglion cell loss. While p53 modulates apoptosis, gene association studies between p53 variants and glaucoma have been inconsistent. In this study we evaluate the association between
Externí odkaz:
https://doaj.org/article/23cf4157ef054dd488041e9c0256275a
Autor:
David P Dimasi, Alex W Hewitt, Kenneth Kagame, Sam Ruvama, Ludovica Tindyebwa, Bastien Llamas, Kirsty A Kirk, Paul Mitchell, Kathryn P Burdon, Jamie E Craig
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22103 (2011)
The cornea is a transparent structure that permits the refraction of light into the eye. Evidence from a range of studies indicates that central corneal thickness (CCT) is strongly genetically determined. Support for a genetic component comes from da
Externí odkaz:
https://doaj.org/article/c921b5b79e0e49ef85b0aa45ccf87ee2
Autor:
Yi Lu, David P Dimasi, Pirro G Hysi, Alex W Hewitt, Kathryn P Burdon, Tze'Yo Toh, Jonathan B Ruddle, Yi Ju Li, Paul Mitchell, Paul R Healey, Grant W Montgomery, Narelle Hansell, Timothy D Spector, Nicholas G Martin, Terri L Young, Christopher J Hammond, Stuart Macgregor, Jamie E Craig, David A Mackey
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000947 (2010)
Central corneal thickness (CCT), one of the most highly heritable human traits (h(2) typically>0.9), is important for the diagnosis of glaucoma and a potential risk factor for glaucoma susceptibility. We conducted genome-wide association studies in f
Externí odkaz:
https://doaj.org/article/99e1c7bb125743df91c7a154f6832d64
Autor:
David P. Dimasi, David A. Mackey, Carmel Toomes, Amy C Cohn, Neil Howell, Jamie E Craig, Alex W. Hewitt
Publikováno v:
British Journal of Ophthalmology. 90:1420-1424
Aims: To investigate the role of the common OPTN Met98Lys variant as a risk allele in open-angle glaucoma (OAG), autosomal dominant optic atrophy (ADOA) and Leber’s hereditary optic neuropathy (LHON). Methods: The presence of the Met98Lys variant w
Autor:
Kathryn P. Burdon, Jamie E Craig, John P. M. Wood, Shiwani Sharma, Robert J Casson, David P. Dimasi, Glyn Chidlow
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75067 (2013)
PLoS ONE
PLoS ONE
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
It has re
It has re
Autor:
Ananth C. Viswanathan, Jian Yang, Ozren Polasek, Paul Mitchell, James F. Wilson, Caroline Hayward, Unnur Thorsteinsdottir, Colin E. Willoughby, Kathryn P. Burdon, Grant W. Montgomery, Wishal D. Ramdas, Jie Jin Wang, Ching-Yu Cheng, Michael G. Anderson, Richard A. Mills, Roger C. W. Wolfs, Veronique Vitart, Jae H. Kang, Jianjun Liu, Alireza Mirshahi, David A. Mackey, Brian W Fleck, Terri L. Young, Yaron S. Rabinowitz, Eranga N. Vithana, Jamie E Craig, Kent D. Taylor, Zoran Vatavuk, Jenny Mountain, Clement C Y Tham, Caroline C W Klaver, Tin Aung, Allison E. Ashley-Koch, Alan F. Wright, Alex MacLeod, Tanja Zeller, Sarah Ennis, Nicholas G. Martin, David S. Siscovick, Sayoko E. Moroi, Li J. Chen, David P. Dimasi, Yelena Bykhovskaya, Kari Stefansson, Yi Lu, Seyhan Yazar, Pirro G. Hysi, Angela J. Cree, Louis R. Pasquale, Wei Ang, Ayse Bilge Ozel, Megan Ulmer, Stuart MacGregor, Janey L. Wiggs, Dexter Y L Leung, Harry Campbell, Jonathan L. Haines, Cornelia M. van Duijn, Igor Rudan, Tim D. Spector, René Hoehn, E. Shyong Tai, Wan Ting Tay, Michael A. Hauser, Jun Li, Craig E. Pennell, Henriët Springelkamp, Karl J. Lackner, Tien Yin Wong, Jane Gibson, Norbert Pfeiffer, Seang-Mei Saw, Virginie J. M. Verhoeven, Gudmar Thorleifsson, R. Rand Allingham, Julia E. Richards, Jia Nee Foo, Raphaële Castagné, Christopher J Hammond, Fridbert Jonasson, Belinda K. Cornes, Andrew J. Lotery, Brian L. Yaspan, Franz H. Grus, Chi P. Pang, Chiea Chuen Khor, Jerome I. Rotter, Xiaohui Li, Demelza Koehn, Alex W. Hewitt
Publikováno v:
Lu, Y, Vitart, V, Burdon, K P, Khor, C C, Bykhovskaya, Y, Mirshahi, A, Hewitt, A W, Koehn, D, Hysi, P G, Ramdas, W D, Zeller, T, Vithana, E N, Cornes, B K, Tay, W-T, Tai, E S, Cheng, C-Y, Liu, J, Foo, J-N, Saw, S M, Thorleifsson, G, Stefansson, K, Dimasi, D P, Mills, R A, Mountain, J, Ang, W, Hoehn, R, Verhoeven, V J M, Grus, F, Wolfs, R, Castagne, R, Lackner, K J, Springelkamp, H, Yang, J, Jonasson, F, Leung, D Y L, Chen, L J, Tham, C C Y, Rudan, I, Vatavuk, Z, Hayward, C, Gibson, J, Cree, A J, Macleod, A, Ennis, S, Polasek, O, Campbell, H, Wilson, J F, Viswanathan, A C & Fleck, B & Wright, A F 2013, ' Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus ', Nature Genetics, vol. 45, no. 2, pp. 155-163 . https://doi.org/10.1038/ng.2506
Nature Genetics, 45(2), 155-163. Nature Publishing Group
Nature Genetics, 45(2), 155-163. Nature Publishing Group
The author manuscript of this article is open access and is freely available online at PubMed Central
Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 i
Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8747a7955b4dfc558416424570a97d
https://www.pure.ed.ac.uk/ws/files/14425060/Genome_wide_association_analyses_identify_multiple_loci_associated_with_central_corneal_thickness_and_keratoconus.pdf
https://www.pure.ed.ac.uk/ws/files/14425060/Genome_wide_association_analyses_identify_multiple_loci_associated_with_central_corneal_thickness_and_keratoconus.pdf
Autor:
John Landers, Paul Mitchell, Patrick Danoy, April Crawford, Kathryn P. Burdon, Shahrbanou Javadiyan, Shiwani Sharma, David P. Dimasi, Sarah Martin, David A. Mackey, Glyn Chidlow, Sonja Klebe, Jamie E Craig, John P. M. Wood, Alex W. Hewitt, Kim M. Griggs, Robert J Casson, Alpana Dave
Publikováno v:
IndraStra Global.
Purpose. Glaucoma is the leading cause of irreversible blindness worldwide. Primary open angle glaucoma (POAG) is the most common subtype. We recently reported association of genetic variants at chromosomal loci, 1q24 and 9p21, with POAG. In this stu
Autor:
David P, Dimasi, Kathryn P, Burdon, Alex W, Hewitt, Ravi, Savarirayan, Paul R, Healey, Paul, Mitchell, David A, Mackey, Jamie E, Craig
Publikováno v:
Molecular Vision
Purpose The genetic component underlying variation in central corneal thickness (CCT) in the normal population remains largely unknown. As CCT is an identified risk factor for open-angle glaucoma, understanding the genes involved in CCT determination
Publikováno v:
The British journal of ophthalmology. 94(8)
Evidence in the recent literature has highlighted the importance of central corneal thickness (CCT) in relation to several ocular and non-ocular conditions. Most notably, thinner CCT has been identified as a risk factor for open-angle glaucoma. Despi