Zobrazeno 1 - 10
of 35
pro vyhledávání: '"David P. Astling"'
Autor:
Igor Kogut, Sandra M. McCarthy, Maryna Pavlova, David P. Astling, Xiaomi Chen, Ana Jakimenko, Kenneth L. Jones, Andrew Getahun, John C. Cambier, Anna M. G. Pasmooij, Marcel F. Jonkman, Dennis R. Roop, Ganna Bilousova
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Induced pluripotent stem cells (iPSCs) have potential for regenerative medicine applications, but are generated with very low efficiency. Here, the authors show highly efficient reprogramming of human primary fibroblasts to iPSCs via the synergistic
Externí odkaz:
https://doaj.org/article/279523f467794ff7bb0f3d426b9968a3
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background DUF1220 protein domains found primarily in Neuroblastoma BreakPoint Family (NBPF) genes show the greatest human lineage-specific increase in copy number of any coding region in the genome. There are 302 haploid copies of DUF1220 i
Externí odkaz:
https://doaj.org/article/ab922f62a8b24d3988ac8a7ca0e6c4b1
Autor:
Alexandra M. Gehring, David P. Astling, Rie Matsumi, Brett W. Burkhart, Zvi Kelman, John N. Reeve, Kenneth L. Jones, Thomas J. Santangelo
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
The initiation of DNA replication is typically tightly regulated by proteins that form initiation complexes at specific sequences known as replication origins. In Archaea and Eukaryotes, Cdc6, a near-universally conserved protein binds and facilitate
Externí odkaz:
https://doaj.org/article/16d3490f41564cedbb2e272ded197272
Autor:
Antonio Jimeno, Aik-Choon Tan, Marileila Varella-Garcia, Barbara A. Frederick, Francois Wilhelm, Dara L. Aisner, Sarah M. Takimoto, Daniel Sehrt, Brian W. Vogler, Gregory N. Gan, Justin Eagles-Soukup, Adrian Umpierrez, Phuong Le, J. Jason Morton, David P. Astling, Magdalena J. Glogowska, Daniel W. Bowles, Stephen B. Keysar, Ryan T. Anderson
PDF file - 64K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8e7717de4950956e210d0d4a5249dc
https://doi.org/10.1158/1535-7163.22497478
https://doi.org/10.1158/1535-7163.22497478
Autor:
Antonio Jimeno, Aik-Choon Tan, Marileila Varella-Garcia, Barbara A. Frederick, Francois Wilhelm, Dara L. Aisner, Sarah M. Takimoto, Daniel Sehrt, Brian W. Vogler, Gregory N. Gan, Justin Eagles-Soukup, Adrian Umpierrez, Phuong Le, J. Jason Morton, David P. Astling, Magdalena J. Glogowska, Daniel W. Bowles, Stephen B. Keysar, Ryan T. Anderson
The dual pathway inhibitor rigosertib inhibits phosphoinositide 3-kinase (PI3K) pathway activation as well as polo-like kinase 1 (PLK1) activity across a broad spectrum of cancer cell lines. The importance of PIK3CA alterations in squamous cell carci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36906326f4b2438531275d5ad4819da3
https://doi.org/10.1158/1535-7163.c.6535627.v1
https://doi.org/10.1158/1535-7163.c.6535627.v1
Autor:
Antonio Jimeno, Wells A. Messersmith, S. Gail Eckhardt, Manoj Maniar, Francois Wilhelm, Aik-Chook Tan, Chen Ren, Dara L. Aisner, Elizabeth Freas, Stephen B. Keysar, Brian W. Vogler, Marileila Varella-Garcia, Lia Gore, Stephen Leong, Ryan T. Anderson, David P. Astling, Colin D. Weekes, Elaine T. Lam, Jennifer R. Diamond, Daniel W. Bowles
Purpose: To determine the pharmacokinetics (PK), maximum tolerated dose (MTD), safety, and antitumor activity of an oral formulation of rigosertib, a dual phosphoinositide 3-kinase (PI3K) and polo-like kinase 1 (Plk1) pathway inhibitor, in patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5821806c41159b147bc979b7d3495244
https://doi.org/10.1158/1078-0432.c.6522141.v1
https://doi.org/10.1158/1078-0432.c.6522141.v1
Autor:
Antonio Jimeno, Wells A. Messersmith, S. Gail Eckhardt, Manoj Maniar, Francois Wilhelm, Aik-Chook Tan, Chen Ren, Dara L. Aisner, Elizabeth Freas, Stephen B. Keysar, Brian W. Vogler, Marileila Varella-Garcia, Lia Gore, Stephen Leong, Ryan T. Anderson, David P. Astling, Colin D. Weekes, Elaine T. Lam, Jennifer R. Diamond, Daniel W. Bowles
Supplemental Figure S1: Supplemental Figure 1 shows the pharmacokinetic plasma concentration curve following a single dose of oral rigosertib, revealing dose-dependent pharmacokinetics; Supplemental Table S1: This file provides individual patient cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6aba3c32b70b6fb714ad732fb1c09e2
https://doi.org/10.1158/1078-0432.22451247.v1
https://doi.org/10.1158/1078-0432.22451247.v1
Autor:
Paul S. MacLean, Pepper S. Schedin, Aik-Choon Tan, Sonali Jindal, Ann D. Thor, Steven M. Anderson, David P. Astling, Elizabeth A. Wellberg, Erin D. Giles
PDF file - 219K, Supplemental Methods, including: (1)Detailed description of obesity and postmenopausal breast cancer model (2)Criteria for removal of animals from the study (3)Western blotting methods (4)Detailed methods for adipocyte cellularity Su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488857a182be099c711d8e8ae7bef872
https://doi.org/10.1158/0008-5472.22395690
https://doi.org/10.1158/0008-5472.22395690
Autor:
Paul S. MacLean, Pepper S. Schedin, Aik-Choon Tan, Sonali Jindal, Ann D. Thor, Steven M. Anderson, David P. Astling, Elizabeth A. Wellberg, Erin D. Giles
Obese postmenopausal women have increased risk of breast cancers with poorer clinical outcomes than their lean counterparts. However, the mechanisms underlying these associations are poorly understood. Rodent model studies have recently identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2247c07ab4948221d83aa5f85cb0009f
https://doi.org/10.1158/0008-5472.c.6504375
https://doi.org/10.1158/0008-5472.c.6504375
Autor:
Larry Gold, Nebojsa Janjic, Edward N. Brody, Guillot Jessica, Steven K. Wolk, David P. Astling, Wesley S. Mayfield, Amy D. Gelinas
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The modern version of the RNA World Hypothesis begins with activated ribonucleotides condensing (nonenzymatically) to make RNA molecules, some of which possess (perhaps slight) catalytic activity. We propose that noncanonical ribonucleotides, which w