Zobrazeno 1 - 10
of 310
pro vyhledávání: '"David P Siderovski"'
Autor:
Adam B Schroer, Junaith S Mohamed, Melinda D Willard, Vincent Setola, Emily Oestreich, David P Siderovski
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0216167 (2019)
Regulators of G Protein Signaling (RGS proteins) inhibit G protein-coupled receptor (GPCR) signaling by accelerating the GTP hydrolysis rate of activated Gα subunits. Some RGS proteins exert additional signal modulatory functions, and RGS12 is one s
Externí odkaz:
https://doaj.org/article/91c5797ef9b144e89da277b344d6565d
Autor:
Tresa George, Matthew Bell, Mainak Chakraborty, David P Siderovski, Mark A Giembycz, Robert Newton
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170269 (2017)
The GTPase-accelerating protein, regulator of G-protein signalling 2 (RGS2) reduces signalling from G-protein-coupled receptors (GPCRs) that signal via Gαq. In humans, RGS2 expression is up-regulated by inhaled corticosteroids (ICSs) and long-acting
Externí odkaz:
https://doaj.org/article/572fe8d91a2047e4a7e647fc646c4bf5
Autor:
Michel Guipponi, Federico A Santoni, Vincent Setola, Corinne Gehrig, Maud Rotharmel, Macarena Cuenca, Olivier Guillin, Dimitris Dikeos, Georgios Georgantopoulos, George Papadimitriou, Logos Curtis, Alexandre Méary, Franck Schürhoff, Stéphane Jamain, Dimitri Avramopoulos, Marion Leboyer, Dan Rujescu, Ann Pulver, Dominique Campion, David P Siderovski, Stylianos E Antonarakis
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141630 (2015)
Externí odkaz:
https://doaj.org/article/963ed32e16e74ae781d3e8f65c32befa
Autor:
Michel Guipponi, Federico A Santoni, Vincent Setola, Corinne Gehrig, Maud Rotharmel, Macarena Cuenca, Olivier Guillin, Dimitris Dikeos, Georgios Georgantopoulos, George Papadimitriou, Logos Curtis, Alexandre Méary, Franck Schürhoff, Stéphane Jamain, Dimitri Avramopoulos, Marion Leboyer, Dan Rujescu, Ann Pulver, Dominique Campion, David P Siderovski, Stylianos E Antonarakis
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112745 (2014)
Schizophrenia (SCZ) is a severe, debilitating mental illness which has a significant genetic component. The identification of genetic factors related to SCZ has been challenging and these factors remain largely unknown. To evaluate the contribution o
Externí odkaz:
https://doaj.org/article/64361a017d1d41eb8033734ff0470ebd
Autor:
Jennie Garcia-Olivares, Delany Torres-Salazar, William A Owens, Tracy Baust, David P Siderovski, Susan G Amara, Jun Zhu, Lynette C Daws, Gonzalo E Torres
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59788 (2013)
Uptake through the Dopamine Transporter (DAT) is the primary mechanism of terminating dopamine signaling within the brain, thus playing an essential role in neuronal homeostasis. Deregulation of DAT function has been linked to several neurological an
Externí odkaz:
https://doaj.org/article/42b8cc8b80754619b13b8ac662609f99
Autor:
Dustin E Bosch, Francis S Willard, Ravikrishna Ramanujam, Adam J Kimple, Melinda D Willard, Naweed I Naqvi, David P Siderovski
Publikováno v:
PLoS Pathogens, Vol 8, Iss 2, p e1002553 (2012)
Heterotrimeric G-proteins are molecular switches integral to a panoply of different physiological responses that many organisms make to environmental cues. The switch from inactive to active Gαβγ heterotrimer relies on nucleotide cycling by the G
Externí odkaz:
https://doaj.org/article/c8d316eb8abe46629e2463a57a3ec01b
Autor:
Dustin E Bosch, Adam J Kimple, Robin E Muller, Patrick M Giguère, Mischa Machius, Francis S Willard, Brenda R S Temple, David P Siderovski
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1003040 (2012)
Heterotrimeric G-protein signaling pathways are vital components of physiology, and many are amenable to pharmacologic manipulation. Here, we identify functional heterotrimeric G-protein subunits in Entamoeba histolytica, the causative agent of amoeb
Externí odkaz:
https://doaj.org/article/4362270682cc4067a9e0e1c85c876670
Autor:
Francis S Willard, Melinda D Willard, Adam J Kimple, Meera Soundararajan, Emily A Oestreich, Xiaoyan Li, Nathaniel A Sowa, Randall J Kimple, Declan A Doyle, Channing J Der, Mark J Zylka, William D Snider, David P Siderovski
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4884 (2009)
Regulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Galpha-mediated GTP hydrolysis ("GTPase-accelerating proteins" or GAPs). However, RGS proteins with complex domain architectures are now known to regulate muc
Externí odkaz:
https://doaj.org/article/e73be97520f24b928d7268fff21c829a
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Cognitive decline in Parkinson’s disease (PD) is a critical premotor sign that may occur in approximately 40% of PD patients up to 10 years prior to clinical recognition and diagnosis. Delineating the mechanisms and specific behavioral signs of cog
Externí odkaz:
https://doaj.org/article/96f62cda69934543be6094b7c62b33e8
Potential for Kappa-Opioid Receptor Agonists to Engineer Nonaddictive Analgesics: A Narrative Review
Publikováno v:
Anesth Analg
A serious adverse effect of prescription opioid analgesics is addiction, both to these analgesics and to illicit drugs like heroin that also activate the mu opioid receptor (MOR). Opioid Use Disorder (OUD) and opioid overdose deaths represent a curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfffafc723977b8649f3fd4b565e6a8
https://doi.org/10.1213/ane.0000000000005309
https://doi.org/10.1213/ane.0000000000005309