Zobrazeno 1 - 10
of 25
pro vyhledávání: '"David P Sebesta"'
Autor:
Harri Lönnberg, Luis Sanchez-Perez, Vivian Negron, David P Sebesta, Shawn Zinnen, Monica M. Reinholz, Diane F. Jelinek, Anthony J. Croatt, Amylou C. Dueck, Leslie M. Jonart, Henry B F Hal Dixon, James N. Ingle, Wilma L. Lingle, Thomas C. Spelsberg, Toshiyuki Yoneda, Gregory G. Reinholz, David Dingli, Kathleen A Kitzmann, Karl A. Nath, Abdalla K Abdalla, Bonnie K. Arendt, Stephen J. Russell, Alexander Karpeisky, Amy K Bruzek
Publikováno v:
Bone. 47:12-22
Despite palliative treatments, tumor-induced bone disease (TIBD) remains highly debilitating for many cancer patients and progression typically results in death within two years. Therefore, more effective therapies with enhanced anti-resorptive and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551b1530cde98df8044875e1157ad4f0
https://doi.org/10.1016/j.bone.2010.03.006
https://doi.org/10.1016/j.bone.2010.03.006
Autor:
Kurt Vagle, Michael Leuck, Ken Hill, Jeffrey D. Carter, Jon Taunton-Rigby, Danny P. C. McGee, Dominic J. Anziano, David P. Sebesta, Wolfgang Pieken, Gregory M. Husar, Eric Kropp
Publikováno v:
The Journal of Organic Chemistry. 66:5352-5358
In an effort to offer complementary technology for covalent biomolecule modification (bioconjugation), we have developed a method that exploits the aqueous acceleration of Diels--Alder reactions for this purpose. Three different diene phosphoramidite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d246810c2e923405baf23895dc34ac
https://doi.org/10.1021/jo0100190
https://doi.org/10.1021/jo0100190
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 20:559-566
The importance of chemically modified and surface immobilized nucleic acids has inspired the development of a wide variety of complementary techniques for covalent oligonucleotide preparation and immobilization. We are developing technology based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a9df25943083fb27c877ea6106b5a5
https://doi.org/10.1081/ncn-100002332
https://doi.org/10.1081/ncn-100002332
Autor:
and David P. Sebesta, Randall S. Smith, Wolfgang Pieken, Gretchen M. Pratt, Kurt Vagle, Christopher J. Tompkins, T. Brian Hurley, John Yegge, Jeffery C. Mihaichuk
Publikováno v:
Organic Process Research & Development. 4:214-224
Presented is a conceptually novel approach to oligonucleotide synthesis referred to herein as dimethoxytrityl resin product anchored sequential synthesis (DMT PASS). The DMT PASS process is characterized by the reaction of a 3‘-protected nucleoside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd0ea47848fe164e390107a9d4127d18
https://doi.org/10.1021/op990095t
https://doi.org/10.1021/op990095t
Publikováno v:
Tetrahedron. 53:8825-8836
The stereoselectivity of the reactions of d -glucal derivatives with PhSCl and PhSeCl is dependent on the presence of an electronegative heteroatom substituent at C(6) and the nature of the functionality at C(4). The C(6)-substituent influences the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a27dac147a23288c4c8a303bcb121447
https://doi.org/10.1016/s0040-4020(97)90394-x
https://doi.org/10.1016/s0040-4020(97)90394-x
Publikováno v:
Tetrahedron. 53:8837-8852
We have demonstrated that 4-O-acetyl-6-bromo-3-O-(tert-butyldimethylsilyl)-2-deoxy-2-thiophenyl-1-trichloroacetimido-α- d -glucopyranose 11b is the most efficient and selective donor for use in the synthesis of 2-deoxy-β-glycosides of the series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f757aacd88bb838dac0d8fd94c1b214
https://doi.org/10.1016/s0040-4020(97)90395-1
https://doi.org/10.1016/s0040-4020(97)90395-1
Publikováno v:
Tetrahedron. 52:14385-14402
Natural and unnatural modified nucleosides and nucleotides play important roles in biology, medicine, and as biomedical research tools. Reported herein is an application of synthetic methodology developed for the stereo- and regiospecific introductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::614927c13844c589dbf22e95c75a43e3
https://doi.org/10.1016/0040-4020(96)00870-8
https://doi.org/10.1016/0040-4020(96)00870-8
Autor:
Michael E. Jung, S. S. O'rourke, David P. Sebesta, Rogelio L. Martinez, Danny P. C. McGee, Wolfgang Pieken
Publikováno v:
Tetrahedron Letters. 37:1995-1998
The generation of novel ribonucleoside analogues derived from 2,2′-anhydrouridines by a 3′-hydroxyl directed intramolecular nucleophilic substitution of the 2′-position is described. The methodology allows for the efficient, regio- and stereose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bddfcc1a9c589edb25ae2b768af8e713
https://doi.org/10.1016/0040-4039(96)00227-4
https://doi.org/10.1016/0040-4039(96)00227-4
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::073b86795c095f5128af92c7c3afde99
https://doi.org/10.1002/chin.199403218
https://doi.org/10.1002/chin.199403218