Zobrazeno 1 - 10
of 657
pro vyhledávání: '"David P Ryan"'
Autor:
Albiruni RA Razak, James M Cleary, Michael Boyer, Emiliano Calvo Aller, William Edenfield, R Donald Harvey, Annemie Rutten, David P Ryan, Hansen Wong, Neelesh Soman, Marie-Anne Damiette Smit
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background To determine the safety and efficacy of the anti-colony-stimulating factor 1 receptor (anti-CSF1R) monoclonal antibody AMG 820 in combination with pembrolizumab in patients with select solid tumors.Patients and methods Patients had advance
Externí odkaz:
https://doaj.org/article/c86d4e961e1c408ea5c8168b4d7c83df
Autor:
Ilaria Pergolini, Vicente Morales-Oyarvide, Mari Mino-Kenudson, Kim C Honselmann, Matthew W Rosenbaum, Sabikun Nahar, Marina Kem, Cristina R Ferrone, Keith D Lillemoe, Nabeel Bardeesy, David P Ryan, Sarah P Thayer, Andrew L Warshaw, Carlos Fernández-Del Castillo, Andrew S Liss
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182855 (2017)
Patient-derived xenograft (PDX) tumors are powerful tools to study cancer biology. However, the ability of PDX tumors to model the biological and histological diversity of pancreatic ductal adenocarcinoma (PDAC) is not well known. In this study, we s
Externí odkaz:
https://doaj.org/article/bf4d5669542f4d358dfa11126546b659
Publikováno v:
Radiology Case Reports, Vol 19, Iss 1, Pp 78-81 (2024)
Chronic exertional compartment syndrome is well documented in the distal extremities, but is rare in the thighs. We present the case of a 19-year-old male who presented with chronic, recurrent bilateral thigh pain induced by physical activity, which
Externí odkaz:
https://doaj.org/article/ef1ad6c5bd504851b9d1e039bbd19ab7
Publikováno v:
Radiology Case Reports, Vol 18, Iss 9, Pp 3287-3290 (2023)
We report the case of a 50-year old woman with a known history of lipodystrophy. A pelvic radiograph was taken for the investigation of right hip pain. The image shown demonstrates an indeterminate artefact projected over the right iliac fossa. A pre
Externí odkaz:
https://doaj.org/article/483650f3ed84436fa6b07b55c5917ffa
Publikováno v:
Children, Vol 11, Iss 2, p 256 (2024)
Cystic fibrosis (CF) is one of the most common progressive life-shortening genetic conditions worldwide. Ground-breaking translational research has generated therapies that target the primary cystic fibrosis transmembrane conductance regulator (CFTR)
Externí odkaz:
https://doaj.org/article/cfb3149dc2e54fed9e8f6fac80faeb5d
Publikováno v:
European Cardiology Review, Vol 17, Iss , Pp - (2022)
Chronic kidney disease (CKD) is increasingly prevalent in patients with heart failure (HF) and HF is one of the leading causes of hospitalisation, morbidity and mortality in patients with impaired renal function. Currently, there is strong evidence t
Externí odkaz:
https://doaj.org/article/bfaf17f59ee64b169f3ada1c50f740b2
Autor:
Yves Boucher, Jessica M. Posada, Sonu Subudhi, Ashwin S. Kumar, Spencer R. Rosario, Liqun Gu, Heena Kumra, Mari Mino-Kenudson, Nilesh P. Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P. Ryan, Carlos Fernandez-Del Castillo, Theodore S. Hong, Mikael J. Pittet, Rakesh K. Jain
Publikováno v:
Clinical Cancer Research. 29:1605-1619
Purpose: Adding losartan (LOS) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer (LAPC). Here we identify potential mechan
Autor:
Richard Kim, Alexis D. Leal, Aparna Parikh, David P. Ryan, Shining Wang, Brittany Bahamon, Neeraj Gupta, Aaron Moss, Joanna Pye, Harry Miao, Haig Inguilizian, James M. Cleary
Publikováno v:
Cancer Chemotherapy and Pharmacology. 91:291-300
Purpose Guanylyl cyclase C (GCC) is highly expressed in several gastrointestinal malignancies and preclinical studies suggest that it is a promising target for antibody-based therapeutics. This phase I trial assessed the safety and tolerability of TA
Autor:
Jun Tian, Jonathan H. Chen, Sherry X. Chao, Karin Pelka, Marios Giannakis, Julian Hess, Kelly Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, Tomonori Oka, Mei Huang, David Lieb, Maxwell Spurrell, Jill N. Allen, Thomas A. Abrams, Jeffrey W. Clark, Andrea C. Enzinger, Peter C. Enzinger, Samuel J. Klempner, Nadine J. McCleary, Jeffrey A. Meyerhardt, David P. Ryan, Matthew B. Yurgelun, Katie Kanter, Emily E. Van Seventer, Islam Baiev, Gary Chi, Joy Jarnagin, William B. Bradford, Edmond Wong, Alexa G. Michel, Isobel J. Fetter, Giulia Siravegna, Angelo J. Gemma, Arlene Sharpe, Shadmehr Demehri, Rebecca Leary, Catarina D. Campbell, Omer Yilmaz, Gad A. Getz, Aparna R. Parikh, Nir Hacohen, Ryan B. Corcoran
Publikováno v:
Nature Medicine. 29:458-466
While BRAF inhibitor combinations with EGFR and/or MEK inhibitors have improved clinical efficacy in BRAFV600E colorectal cancer (CRC), response rates remain low and lack durability. Preclinical data suggest that BRAF/MAPK pathway inhibition may augm
Autor:
Zhi Ven Fong, Fidel Lopez Verdugo, Carlos Fernandez-del Castillo, Cristina R Ferrone, Jill N Allen, Lawrence S Blaszkowsky, Jeffrey W Clark, Aparna R Parikh, David P Ryan, Colin D Weekes, Theodore S Hong, Jennifer Y Wo, Keith D Lillemoe, Motaz Qadan
Publikováno v:
Journal of the American College of Surgeons. 236:1126-1136