Zobrazeno 1 - 10
of 85
pro vyhledávání: '"David P Rotella"'
Autor:
Andrew M Tobias, Dea Toska, Keith Lange, Tyler Eck, Rohit Bhat, Cheryl A Janson, David P Rotella, Ueli Gubler, Nina M Goodey
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197173 (2018)
Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia malayi DHFR
Externí odkaz:
https://doaj.org/article/2c8a0df7e2ef4f8b811d5074508981ba
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79834 (2013)
(-)-Epigallocatechin 3-O-gallate (EGCG) a molecule found in green tea and known for a plethora of bioactive properties is an inhibitor of heat shock protein 90 (HSP90), a protein of interest as a target for cancer and neuroprotection. Determination o
Externí odkaz:
https://doaj.org/article/4145d762aa7146a995af3c6f5167b119
Autor:
David P. Rotella
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery. :1-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fec73016da7ca429b8b0627ecbe0ec1
https://doi.org/10.1002/0471266949.bmc200.pub2
https://doi.org/10.1002/0471266949.bmc200.pub2
Autor:
Tyler Eck, Mariana Laureano de Souza, Melvin Delvillar, Kutub Ashraf, Rammohan R. Yadav Bheemanaboina, Ramappa Chakrasali, Tamara Kreiss, John J. Siekierka, David P. Rotella, Purnima Bhanot, Nina M. Goodey
Publikováno v:
Chembiochem
P. falciparum cGMP-dependent protein kinase (PfPKG) is an enticing anti-malarial drug target. Novel chemotypes are needed because existing inhibitors have safety issues that may prevent further development. This work demonstrates isoxazole-based comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cbf8dfbddf28ef59a5017fb94c15ac
https://pubmed.ncbi.nlm.nih.gov/35044710
https://pubmed.ncbi.nlm.nih.gov/35044710
Autor:
Tyler Eck, John Gordon, Wayne E. Childers, Brandon S. Pybus, Dennis J. Colussi, Tamara Kreiss, Alison Roth, Rammohan R. Yadav Bheemanaboina, David P. Rotella, Shams Ul Mahmood, Patricia J. Lee, Purnima Bhanot, Samantha O. Aylor, Mariana Laureano de Souza, Mariana Lozano Gonzalez, John J. Siekierka
Publikováno v:
ACS Med Chem Lett
[Image: see text] The discovery of new targets for the treatment of malaria, in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8fe3378b6bb8e06313fdebf1e4dbd7
https://europepmc.org/articles/PMC8667308/
https://europepmc.org/articles/PMC8667308/
Autor:
Purnima Bhanot, Mariana Lozano Gonzalez, Brandon S. Pybus, John Gordon, Wayne E. Childers, David P. Rotella, Rammohan R. Yadav Bheemanaboina, Alison Roth, Shams Ul Mahmood, Tamara Kreiss, Tyler Eck, Mariana Laureano de Souza, John J. Siekierka, Dennis J. Colussi, Patricia J. Lee, Samantha O. Aylor
The discovery of new targets for treatment of malaria and in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-dependent protein k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77f95d28b1facf94164495dca7105a0f
https://doi.org/10.1101/2021.11.05.467463
https://doi.org/10.1101/2021.11.05.467463
Autor:
Mariana Lozano Gonzalez, Dennis J. Colussi, Tyler Eck, Samantha O. Aylor, Patty J. Lee, Shams Ul Mahmood, Tamara Kreiss, David P. Rotella, Brandon S. Pybus, Purnima Bhanot, Wayne E. Childers, John Gordon, Alison Roth, Rammohan R. Yadav Bheemanaboina, M. L. de Souza, John J. Siekierka
The discovery of new targets for treatment of malaria advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) could clear infection in a murine model. This enthusiasm was temp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c612db0e19258f774179b67ca88c35b6
https://doi.org/10.1101/2021.08.24.457553
https://doi.org/10.1101/2021.08.24.457553
Autor:
Nina M. Goodey, Bheemanoboina Rry, Tyler Eck, John J. Siekierka, Ramappa Chakrasali, Purnima Bhanot, Laureano de Souza M, Tamara Kreiss, David P. Rotella
P. falciparum cGMP-dependent protein kinase (PfPKG) is an enticing anti-malarial drug target. Structurally novel isoxazole-based compounds were shown to be ATP competitive inhibitors of PfPKG. Isoxazoles 3 and 5 had Ki values of 0.7 ± 0.2 and 2.3 ±
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::354171d010b685e50cfad3da790134e4
https://doi.org/10.1101/2021.06.24.449800
https://doi.org/10.1101/2021.06.24.449800
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 11 (2021)
Frontiers in Microbiology, Vol 11 (2021)
The primary effector of cGMP signaling in Plasmodium is the cGMP-dependent protein kinase (PKG). Work in human-infective Plasmodium falciparum and rodent-infective Plasmodium berghei has provided biological validation of P. falciparum PKG (PfPKG) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d7440894a62d915dd4dcf89471c110
http://europepmc.org/articles/PMC7886688
http://europepmc.org/articles/PMC7886688
Autor:
David P. Rotella
Publikováno v:
Advances in Heterocyclic Chemistry ISBN: 9780128201817
In recent years, understanding ways to improve the value and impact of heterocycles, in drug discovery and medicinal chemistry has increased with understanding of the multitude ways this fragment can influence properties. This chapter defines heteroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26bf22d4c21b82fb717a8b880a4313ac
https://doi.org/10.1016/bs.aihch.2020.10.002
https://doi.org/10.1016/bs.aihch.2020.10.002