Zobrazeno 1 - 10
of 243
pro vyhledávání: '"David P Finn"'
Autor:
Michelle Roche, David P Finn
Publikováno v:
Pharmaceuticals, Vol 3, Iss 8, Pp 2517-2553 (2010)
Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB2 receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression of the CB2 receptor in the b
Externí odkaz:
https://doaj.org/article/b965278831344050b0ae8ad6f789c2e8
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115714- (2023)
Chronic wounds represent a significant burden on the individual, and the healthcare system. Individuals with chronic wounds report pain to be the most challenging aspect of living with a chronic wound, with current therapeutic options deemed insuffic
Externí odkaz:
https://doaj.org/article/fd5c39922c584bcc8992d300f50ff475
Autor:
Niamh McCombe, Jake Bamrah, Jose M. Sanchez‐Bornot, David P. Finn, Paula L. McClean, KongFatt Wong‐Lin, Alzheimer's Disease Neuroimaging Initiative (ADNI)
Publikováno v:
Healthcare Technology Letters, Vol 9, Iss 6, Pp 102-109 (2022)
Abstract Biomarkers for Alzheimer's disease (AD) diagnosis do not always correlate reliably with cognitive symptoms, making clinical diagnosis inconsistent. In this study, the performance of a graphical neural network (GNN) classifier based on data
Externí odkaz:
https://doaj.org/article/d2adecc6ed4a41499ab50a32cb7c79ca
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Dementia is a group of symptoms that largely affects older people. The majority of patients face behavioural and psychological symptoms (BPSD) during the course of their illness. Alzheimer’s disease (AD) and vascular dementia (V
Externí odkaz:
https://doaj.org/article/f686719faeba439d86f60b6a08e63e90
Autor:
Mehnaz I. Ferdousi, Patricia Calcagno, Connie Sanchez, Karen L. Smith, John P. Kelly, Michelle Roche, David P. Finn
Publikováno v:
Frontiers in Pain Research, Vol 4 (2023)
IntroductionChronic pain is often associated with comorbid anxiety and cognitive dysfunction, negatively affecting therapeutic outcomes. The influence of genetic background on such interactions is poorly understood. The stress-hyperresponsive Wistar
Externí odkaz:
https://doaj.org/article/10e5361d06f441ba8957d01cacccae79
Publikováno v:
Frontiers in Pain Research, Vol 3 (2023)
Chronic post-surgical pain affects up to 85% of individuals depending on the type of surgery, the extent of inflammation, tissue and/or nerve damage. Pre-surgical stress is associated with greater pain intensity, prolonged recovery and is one of the
Externí odkaz:
https://doaj.org/article/44dd824c96f94d89a017a9bc780f97c2
Autor:
KongFatt Wong-Lin, Paula L. McClean, Niamh McCombe, Daman Kaur, Jose M. Sanchez-Bornot, Paddy Gillespie, Stephen Todd, David P. Finn, Alok Joshi, Joseph Kane, Bernadette McGuinness
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-10 (2020)
Abstract Background Dementia is caused by a variety of neurodegenerative diseases and is associated with a decline in memory and other cognitive abilities, while inflicting an enormous socioeconomic burden. The complexity of dementia and its associat
Externí odkaz:
https://doaj.org/article/abb460529daa49cf90be570bd2b629c1
Autor:
Bethan Young, John Stephenson, Barira Islam, Nikita N. Burke, Elaine M. Jennings, David P. Finn, Patrick C. McHugh
Publikováno v:
Molecular Neurobiology. 60:1179-1194
Neuropathic pain is a common chronic condition, which remains poorly understood. Many patients receiving treatment continue to experience severe pain, due to limited diagnostic/treatment management programmes. The development of objective clinical di
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 129, Iss , Pp 110456- (2020)
Background: Modulation of the endocannabinoid system has been shown to alleviate neuropathic pain. The aim of this study was to evaluate if treatment with paclitaxel, a chemotherapeutic agent that induces neuropathic pain, affects endocannabinoid lev
Externí odkaz:
https://doaj.org/article/6fc6c4a155c44e4d86dfc0b040291617
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Conflicting results on dementia risk factors have been reported across studies. We hypothesize that variation in data preparation methods may partially contribute to this issue. Methods We propose a comprehensive data preparatio
Externí odkaz:
https://doaj.org/article/89d58d8cb3ab49ab94bb2cf2a0c737f1