Zobrazeno 1 - 10
of 548
pro vyhledávání: '"David P Fairlie"'
Autor:
Shivam K Purohit, Lauren Stern, Alexandra J Corbett, Jeffrey Y W Mak, David P Fairlie, Barry Slobedman, Allison Abendroth
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012372 (2024)
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that respond to riboflavin biosynthesis and cytokines through TCR-dependent and -independent pathways, respectively. MAIT cell activation plays an immunoprotective role against se
Externí odkaz:
https://doaj.org/article/d13784a93f044bc0859490b3039f8b99
Autor:
Thao Thanh Tran, Carmen D Mathmann, Marcela Gatica-Andrades, Rachel F Rollo, Melanie Oelker, Johanna K Ljungberg, Tam T K Nguyen, Alina Zamoshnikova, Lalith K Kummari, Orry J K Wyer, Katharine M Irvine, Javier Melo-Bolívar, Annette Gross, Darren Brown, Jeffrey Y W Mak, David P Fairlie, Karl A Hansford, Matthew A Cooper, Rabina Giri, Veronika Schreiber, Shannon R Joseph, Fiona Simpson, Timothy C Barnett, Jörgen Johansson, Wendy Dankers, James Harris, Timothy J Wells, Ronan Kapetanovic, Matthew J Sweet, Eleanor A Latomanski, Hayley J Newton, Romain J R Guérillot, Abderrahman Hachani, Timothy P Stinear, Sze Ying Ong, Yogeswari Chandran, Elizabeth L Hartland, Bostjan Kobe, Jennifer L Stow, A Elisabeth Sauer-Eriksson, Jakob Begun, Jessica C Kling, Antje Blumenthal
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010166 (2022)
A hallmark of Listeria (L.) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which is required for rapid bacterial replication in the host cell cytoplasm and cell-to-cell spread. The bacterial transcriptional activator Prf
Externí odkaz:
https://doaj.org/article/dd9f42f4ae984ed9acddb02c872b0742
Autor:
Chansavath Phetsouphanh, Prabhjeet Phalora, Carl-Philipp Hackstein, John Thornhill, C Mee Ling Munier, Jodi Meyerowitz, Lyle Murray, Cloete VanVuuren, Dominique Goedhals, Linnea Drexhage, Rebecca A Russell, Quentin J Sattentau, Jeffrey YW Mak, David P Fairlie, Sarah Fidler, Anthony D Kelleher, John Frater, Paul Klenerman
Publikováno v:
eLife, Vol 10 (2021)
Human MAIT cells sit at the interface between innate and adaptive immunity, are polyfunctional and are capable of killing pathogen infected cells via recognition of the Class IB molecule MR1. MAIT cells have recently been shown to possess an antivira
Externí odkaz:
https://doaj.org/article/d6fa8c71230d4e7a8e706bccfc9eda6b
Autor:
Christudas Morais, Retnagowri Rajandram, Jade S Blakeney, Abishek Iyer, Jacky Y Suen, David W Johnson, Glenda C Gobe, David P Fairlie, David A Vesey
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248983 (2021)
Expression of the protease sensing receptor, protease activated receptor-2 (PAR2), is elevated in a variety of cancers and has been promoted as a potential therapeutic target. With the development of potent antagonists for this receptor, we hypothesi
Externí odkaz:
https://doaj.org/article/e7104d0971374f3496ae964db6472cc7
Autor:
Caroline Boulouis, Wan Rong Sia, Muhammad Yaaseen Gulam, Jocelyn Qi Min Teo, Yi Tian Png, Thanh Kha Phan, Jeffrey Y W Mak, David P Fairlie, Ivan K H Poon, Tse Hsien Koh, Peter Bergman, Chwee Ming Lim, Lin-Fa Wang, Andrea Lay Hoon Kwa, Johan K Sandberg, Edwin Leeansyah
Publikováno v:
PLoS Biology, Vol 18, Iss 6, p e3000644 (2020)
Mucosa-associated invariant T (MAIT) cells are abundant antimicrobial T cells in humans and recognize antigens derived from the microbial riboflavin biosynthetic pathway presented by the MHC-Ib-related protein (MR1). However, the mechanisms responsib
Externí odkaz:
https://doaj.org/article/1a7439938aa940da856fd9dd1aad64f2
Autor:
Wilko Duprez, Prabhakar Bachu, Martin J Stoermer, Stephanie Tay, Róisín M McMahon, David P Fairlie, Jennifer L Martin
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133805 (2015)
Antibacterial drugs with novel scaffolds and new mechanisms of action are desperately needed to address the growing problem of antibiotic resistance. The periplasmic oxidative folding system in Gram-negative bacteria represents a possible target for
Externí odkaz:
https://doaj.org/article/2f95337ff29749fc959b5c5d047c8662
Autor:
Fabian Kurth, Kieran Rimmer, Lakshmanane Premkumar, Biswaranjan Mohanty, Wilko Duprez, Maria A Halili, Stephen R Shouldice, Begoña Heras, David P Fairlie, Martin J Scanlon, Jennifer L Martin
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80210 (2013)
Bacterial DsbA enzymes catalyze oxidative folding of virulence factors, and have been identified as targets for antivirulence drugs. However, DsbA enzymes characterized to date exhibit a wide spectrum of redox properties and divergent structural feat
Externí odkaz:
https://doaj.org/article/8ed23e1c163445409bb3a2cacc10b8c6
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59415 (2013)
Protein-based therapeutics feature large interacting surfaces. Protein folding endows structural stability to localised surface epitopes, imparting high affinity and target specificity upon interactions with binding partners. However, short synthetic
Externí odkaz:
https://doaj.org/article/79d79d2f77d44a0fb8774105cc86847a
Autor:
Patricia M Walden, Maria A Halili, Julia K Archbold, Fredrik Lindahl, David P Fairlie, Kenji Inaba, Jennifer L Martin
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81440 (2013)
The α-proteobacterium Wolbachia pipientis infects more than 65% of insect species worldwide and manipulates the host reproductive machinery to enable its own survival. It can live in mutualistic relationships with hosts that cause human disease, inc
Externí odkaz:
https://doaj.org/article/8ab836e21a37448581a777dff3304497
Autor:
Katherine T Andrews, Archna P Gupta, Thanh N Tran, David P Fairlie, Geoffrey N Gobert, Zbynek Bozdech
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31847 (2012)
Histone deacetylase (HDAC) inhibitors are being intensively pursued as potential new drugs for a range of diseases, including malaria. HDAC inhibitors are also important tools for the study of epigenetic mechanisms, transcriptional control, and other
Externí odkaz:
https://doaj.org/article/2662f5cb0f714304aad887d85ebc595f