Zobrazeno 1 - 10
of 185
pro vyhledávání: '"David P Bartel"'
Publikováno v:
eLife, Vol 11 (2022)
MicroRNAs (miRNAs), in association with Argonaute (AGO) proteins, direct repression by pairing to sites within mRNAs. Compared to pairing preferences of the miRNA seed region (nucleotides 2–8), preferences of the miRNA 3′ region are poorly unders
Externí odkaz:
https://doaj.org/article/215a66502c1541fea6bb99de0d44e083
Autor:
Kehui Xiang, David P Bartel
Publikováno v:
eLife, Vol 10 (2021)
In animal oocytes and early embryos, mRNA poly(A)-tail length strongly influences translational efficiency (TE), but later in development this coupling between tail length and TE disappears. Here, we elucidate how this coupling is first established a
Externí odkaz:
https://doaj.org/article/7737bd3ba53542a6a98b01b3461f498a
Autor:
Stephen W Eichhorn, Alexander O Subtelny, Iva Kronja, Jamie C Kwasnieski, Terry L Orr-Weaver, David P Bartel
Publikováno v:
eLife, Vol 5 (2016)
Because maturing oocytes and early embryos lack appreciable transcription, posttranscriptional regulatory processes control their development. To better understand this control, we profiled translational efficiencies and poly(A)-tail lengths througho
Externí odkaz:
https://doaj.org/article/9e766beef5c54d13b5626e53ed04c166
Publikováno v:
eLife, Vol 4 (2015)
MicroRNA targets are often recognized through pairing between the miRNA seed region and complementary sites within target mRNAs, but not all of these canonical sites are equally effective, and both computational and in vivo UV-crosslinking approaches
Externí odkaz:
https://doaj.org/article/a795d72f226e46a8803f727538963f18
Autor:
Eric A Miska, Ezequiel Alvarez-Saavedra, Allison L Abbott, Nelson C Lau, Andrew B Hellman, Shannon M McGonagle, David P Bartel, Victor R Ambros, H Robert Horvitz
Publikováno v:
PLoS Genetics, Vol 3, Iss 12, p e215 (2007)
MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expan
Externí odkaz:
https://doaj.org/article/66adfa1501d9497e90c6c7944b050fa3
Autor:
Peter Y. Wang, David P. Bartel
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background One strategy for identifying targets of a regulatory factor is to perturb the factor and use high-throughput RNA sequencing to examine the consequences. However, distinguishing direct targets from secondary effects and experimenta
Externí odkaz:
https://doaj.org/article/a0013a31e2844e8cbc5b1f021bbf36e5
Autor:
Elena R. Kingston, David P. Bartel
Publikováno v:
RNA
Target-directed microRNA (miRNA) degradation (TDMD), which is mediated by the protein ZSWIM8, plays a widespread role in shaping miRNA abundances across bilateria. Some endogenous small interfering RNAs (siRNAs) of Drosophila cells have target sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e03feaa150f5e049dbe4db79e1919b
https://doi.org/10.1261/rna.078746.121
https://doi.org/10.1261/rna.078746.121
Publikováno v:
eLife. 11
MicroRNAs (miRNAs), in association with Argonaute (AGO) proteins, direct repression by pairing to sites within mRNAs. Compared to pairing preferences of the miRNA seed region (nucleotides 2–8), preferences of the miRNA 3′ region are poorly unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3583157adbc37c230eeab7611ba1ff
https://doi.org/10.7554/elife.69803
https://doi.org/10.7554/elife.69803
Publikováno v:
RNA (New York, N.Y.), vol 28, iss 6
Neurons provide a rich setting for studying post-transcriptional control. Here, we investigate the landscape of translational control in neurons and search for mRNA features that explain differences in translational efficiency (TE), considering the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b2b316a0e0f165d7b0ed4897ba358a
https://pubmed.ncbi.nlm.nih.gov/35273099
https://pubmed.ncbi.nlm.nih.gov/35273099