Výsledky vyhledávání - "David P, Kelsell"

Akademický článek

Investigating iRHOM2-Associated Transcriptional Changes in Tylosis With Esophageal Cancer

Autor: Stephen Murtough, Deepak Babu, Catherine M. Webb, Hélène Louis dit Picard, Lisa A. McGinty, Jennifer Chao-Chu, Ryan Pink, Andrew R. Silver, Howard L. Smart, John K. Field, Philip Woodland, Janet M. Risk, Diana C. Blaydon, Daniel J. Pennington, David P. Kelsell

Publikováno v: Gastro Hep Advances, Vol 3, Iss 3, Pp 385-395 (2024)

Background and Aims: Survival rates for esophageal squamous cell carcinoma (ESCC) are extremely low due to the late diagnosis of most cases. An understanding of the early molecular processes that lead to ESCC may facilitate opportunities for early di

Externí odkaz: https://doaj.org/article/a85cc09e91124fee910a8d340d8707ab

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Akademický článek

Identification of novel immune cell signature in gastroesophageal reflux disease: altered mucosal mast cells and dendritic cell profile

Autor: Ahsen Ustaoglu, Fatema Arif Daudali, Manfredi D’afflitto, Stephen Murtough, Chung Lee, Estefania Moreno, Diana C. Blaydon, David P. Kelsell, Daniel Sifrim, Philip Woodland, Madusha Peiris

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionHeartburn pathogenesis in GERD remains incompletely understood. We aimed to identify differences in the immune cell signature and sensory mucosal markers between reflux phenotypes and healthy asymptomatic subjects.MethodsThirty-seven pati

Externí odkaz: https://doaj.org/article/1ba469e3be464ba592e80e4bda5dc3d3

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Akademický článek

Modeling of Temporal Exposure to the Ambient Environment and Eczema Severity

Autor: Bjorn R. Thomas, Xiang L. Tan, Shagayegh Javadzadeh, Elizabeth J. Robinson, Bryan S. McDonald, Malvina A. Krupiczojc, Syedia R. Rahman, Samiha Rahman, Rehana A. Ahmed, Rubina Begum, Habiba Khanam, David P. Kelsell, Jonathan Grigg, Robert J. Knell, Edel A. O’Toole

Publikováno v: JID Innovations, Vol 2, Iss 1, Pp 100062- (2022)

Atopic eczema is a common and complex disease. Missing genetic hereditability and increasing prevalence in industrializing nations point toward an environmental driver. We investigated the temporal association of weather and pollution parameters with

Externí odkaz: https://doaj.org/article/fd950e63ed2f41b484e5167f6f99ff72

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Deep palmar phenotyping in atopic eczema: patterns associated with filaggrin variants, disease severity and barrier function in a South Asian population

Autor: Bjorn R Thomas, Xiang Li Tan, Stefan Van Duijvenboden, Sarah C Hogan, Aaron J Hughes, Soha S Tawfik, Sasha Dhoat, Ravinder Atkar, Elizabeth J Robinson, Syedia R Rahman, Samiha Rahman, Rehana A Ahmed, Rubina Begum, Habiba Khanam, Emma L Bourne, Eva L Wozniak, Charles A Mein, David P Kelsell, Edel A O’Toole

Publikováno v: British Journal of Dermatology. 188:785-792

Background Hyperlinear palms are described as a feature of loss-of-function (LoF) variants in filaggrin (FLG). Objectives To explore the phenotype of participants (age < 31 years) with atopic eczema of Bangladeshi ancestry from East London and invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc6ad6270e880c510f72f2d0b25b2bf3
https://doi.org/10.1093/bjd/ljad036

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Dermatology Quality of Life Index scores in Bangladeshi patients with atopic eczema and their families in East London

Autor: Soha S Tawfik, Bjorn R Thomas, David P Kelsell, Jonathan Grigg, Edel A O’Toole

Publikováno v: British Journal of Dermatology. 188:524-532

Background Atopic eczema (AE) is a chronic relapsing, pruritic disease that greatly affects the child and family’s quality of life (QoL). It is usually common and severe among children of Bangladeshi ethnicity. Objectives This is a cross-sectional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2a534a789038a9252b7e8a4859805ae
https://doi.org/10.1093/bjd/ljac131

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Akademický článek

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response

Autor: Paola Arcidiacono, Catherine M. Webb, Matthew A. Brooke, Huiqing Zhou, Paul J. Delaney, Keat-Eng Ng, Diana C. Blaydon, Andrew Tinker, David P. Kelsell, Anissa Chikh

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Mutations in the gene encoding iRHOM2 are associated with hyperproliferative epidermal disorders. Here, the authors show that iRHOM2 is a target gene of p63, that together they regulate inflammation, cell survival and response to oxidative stress, an

Externí odkaz: https://doaj.org/article/c3aea6eca2d04247a2f4d1f9bed1b658

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Akademický článek

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

Autor: Thiviyani Maruthappu, Anissa Chikh, Benjamin Fell, Paul J. Delaney, Matthew A. Brooke, Clemence Levet, Angela Moncada-Pazos, Akemi Ishida-Yamamoto, Diana Blaydon, Ahmad Waseem, Irene M. Leigh, Matthew Freeman, David P. Kelsell

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Keratin 16 is an epithelial protein highly expressed at pressure bearing sites and during wound healing and cancer. Here the authors show that K16 interacts with the inactive protease Rhbdf2, associated with Tylosis with oesophageal cancer, and that

Externí odkaz: https://doaj.org/article/b4cfedfe8b0b4b1e98605a9262df868a

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