Zobrazeno 1 - 10
of 138
pro vyhledávání: '"David Oupický"'
Autor:
Laura Flores, Richard Sleightholm, Beth Neilsen, Michael Baine, Andjela Drincic, William Thorell, Nicole Shonka, David Oupicky, Chi Zhang
Publikováno v:
Case Reports in Oncology, Vol 12, Iss 1, Pp 139-146 (2019)
Background: Pituitary tumors typically remain silent unless interaction with nearby structures occurs. Rare subsets of pituitary tumors display aggressive phenotypes: highly mitotic, locally invasive, metastatic, chemotherapy and radiation resistant,
Externí odkaz:
https://doaj.org/article/2eebe8c273114bbda4b3da371866a9d7
Autor:
Tracy Murray-Stewart, Elena Ferrari, Ying Xie, Fei Yu, Laurence J Marton, David Oupicky, Robert A Casero
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178102 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0175917.].
Externí odkaz:
https://doaj.org/article/0d46307286994a9b96a2e3ed61ba3387
Autor:
Tracy Murray-Stewart, Elena Ferrari, Ying Xie, Fei Yu, Laurence J Marton, David Oupicky, Robert A Casero
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175917 (2017)
Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert nanocarriers. We recently described nanocarriers formed from a first-generation polyamine analogue, b
Externí odkaz:
https://doaj.org/article/bb99cdd867ba49acb4ce1c6c0927efe0
Autor:
Farhana Islam, Srijanee Das, Md Ashaduzzaman, Brady Sillman, Pravin Yeapuri, Mohammad Ullah Nayan, David Oupický, Howard E. Gendelman, Bhavesh D. Kevadiya
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract An extended action fostemsavir (FTR) lipid nanoparticle (LNP) formulation prevents human immunodeficiency virus type one (HIV-1) infection. This FTR formulation establishes a drug depot in monocyte-derived macrophages that extend the drug’
Externí odkaz:
https://doaj.org/article/724d71a1580b4ef987734da42550c3e9
Publikováno v:
Bioactive Materials, Vol 25, Iss , Pp 569-579 (2023)
Crosstalk between Kupffer cells (KCs) and hepatic stellate cells (HSCs) plays an important role in multiple liver disease conditions, including the formation of liver fibrosis in alcohol-associated liver disease (AALD). Therapeutic targeting of the K
Externí odkaz:
https://doaj.org/article/a0d8062911cf4c3daf6333314f8a0a5b
Autor:
Zheng-Hong Peng, Chinmay M. Jogdeo, Jing Li, Ying Xie, Yazhe Wang, Yuri M. Sheinin, Jindřich Kopeček, David Oupický
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1725 (2022)
Tremendous progress has been made in the field of nanomedicine for cancer treatment. However, most of the research to date has been focused on inhibiting primary tumor growth with comparatively less efforts directed towards managing tumor metastasis.
Externí odkaz:
https://doaj.org/article/487549c48e8e444596c2ca8476944ef8
Autor:
Diptesh Sil, Sudipta Panja, Chinmay M. Jogdeo, Raj Kumar, Ao Yu, Cassandra E. Holbert, Ling Ding, Jackson R. Foley, Tracy Murray Stewart, Robert A. Casero, David Oupický
Publikováno v:
Molecules, Vol 27, Iss 8, p 2441 (2022)
Conformationally restrained polyamine analog PG11047 is a well-known drug candidate that modulates polyamine metabolism and inhibits cancer cell growth in a broad spectrum of cancers. Here, we report a structure–activity relationship study of the P
Externí odkaz:
https://doaj.org/article/d5eb1279941147268625daa3f0da0089
Autor:
Chuhan Zhang, Yu Hang, Weimin Tang, Diptesh Sil, Heather C. Jensen-Smith, Robert G. Bennett, Benita L. McVicker, David Oupický
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 669 (2022)
Alcohol-associated liver disease (AALD) is a major cause of liver disorders worldwide. Current treatment options are limited, especially for AALD-associated fibrosis. Promising approaches include RNA interference for miR-155 overexpression in Kupffer
Externí odkaz:
https://doaj.org/article/372bcf1685d943d29308743cd40e5f69
Autor:
Amit Wani, Galbokka H. Layan Savithra, Ayat Abyad, Shrey Kanvinde, Jing Li, Stephanie Brock, David Oupický
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Mesoporous silica nanomaterials show great potential to deliver chemotherapeutics for cancer treatment. The key challenges in the development of injectable mesoporous silica formulations are colloidal instability, hemolysis and inefficient d
Externí odkaz:
https://doaj.org/article/fd5f7aded9874910a0599871b2e5257a
Autor:
Yashpal S. Chhonker, Shrey Kanvinde, Rizwan Ahmad, Amar B. Singh, David Oupický, Daryl J. Murry
Publikováno v:
Metabolites, Vol 11, Iss 2, p 106 (2021)
Eicosanoids are key mediators and regulators of inflammation and oxidative stress that are often used as biomarkers for severity and therapeutic responses in various diseases. We here report a highly sensitive LC-MS/MS method for the simultaneous qua
Externí odkaz:
https://doaj.org/article/d4e4f53830a64c4dbc893adbe4b6f8aa