Zobrazeno 1 - 10
of 26
pro vyhledávání: '"David Ortega-Alarcon"'
Autor:
Maria Nuria Peralta-Moreno, Yago Mena, David Ortega-Alarcon, Ana Jimenez-Alesanco, Sonia Vega, Olga Abian, Adrian Velazquez-Campoy, Timothy M. Thomson, Marta Pinto, José M. Granadino-Roldán, Maria Santos Tomas, Juan J. Perez, Jaime Rubio-Martinez
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6119 (2024)
The development of specific antiviral therapies targeting SARS-CoV-2 remains fundamental because of the continued high incidence of COVID-19 and limited accessibility to antivirals in some countries. In this context, dark chemical matter (DCM), a set
Externí odkaz:
https://doaj.org/article/112df38d75b74c1394a53416a4e0597f
Autor:
Maria Nuria Peralta-Moreno, Vanessa Anton-Muñoz, David Ortega-Alarcon, Ana Jimenez-Alesanco, Sonia Vega, Olga Abian, Adrian Velazquez-Campoy, Timothy M. Thomson, José Manuel Granadino-Roldán, Claudia Machicado, Jaime Rubio-Martinez
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 585 (2023)
Over 750 million cases of COVID-19, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), have been reported since the onset of the global outbreak. The need for effective treatments has spurred intensive research for therapeuti
Externí odkaz:
https://doaj.org/article/1390327187704505aca265db9fd93a30
Autor:
Luca Sancineto, Carmine Ostacolo, David Ortega-Alarcon, Ana Jimenez-Alesanco, Laura Ceballos-Laita, Sonia Vega, Olga Abian, Adrian Velazquez-Campoy, Silvia Moretti, Agnieszka Dabrowska, Pawel Botwina, Aleksandra Synowiec, Anna Kula-Pacurar, Krzysztof Pyrc, Nunzio Iraci, Claudio Santi
Publikováno v:
Molecules, Vol 26, Iss 19, p 6062 (2021)
The COVID-19 pandemic outbreak prompts an urgent need for efficient therapeutics, and repurposing of known drugs has been extensively used in an attempt to get to anti-SARS-CoV-2 agents in the shortest possible time. The glycoside rutin shows manifol
Externí odkaz:
https://doaj.org/article/afeb9c5e129745119c7a3b24c486a263
Autor:
Bruno Rizzuti, Laura Ceballos-Laita, David Ortega-Alarcon, Ana Jimenez-Alesanco, Sonia Vega, Fedora Grande, Filomena Conforti, Olga Abian, Adrian Velazquez-Campoy
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 892 (2021)
Inhibiting the main protease 3CLpro is the most common strategy in the search for antiviral drugs to fight the infection from SARS-CoV-2. We report that the natural compound eugenol is able to hamper in vitro the enzymatic activity of 3CLpro, the SAR
Externí odkaz:
https://doaj.org/article/0fd098b68f074739a2149cc059f34f64
Autor:
David Ortega-Alarcon, Rafael Claveria-Gimeno, Sonia Vega, Olga C. Jorge-Torres, Manel Esteller, Olga Abian, Adrian Velazquez-Campoy
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1216 (2021)
Intrinsic disorder plays an important functional role in proteins. Disordered regions are linked to posttranslational modifications, conformational switching, extra/intracellular trafficking, and allosteric control, among other phenomena. Disorder pr
Externí odkaz:
https://doaj.org/article/021217ece19341faaa05c9450fc183ad
Autor:
Francesca Mangiavacchi, Pawel Botwina, Elena Menichetti, Luana Bagnoli, Ornelio Rosati, Francesca Marini, Sérgio F. Fonseca, Laura Abenante, Diego Alves, Agnieszka Dabrowska, Anna Kula-Pacurar, David Ortega-Alarcon, Ana Jimenez-Alesanco, Laura Ceballos-Laita, Sonia Vega, Bruno Rizzuti, Olga Abian, Eder J. Lenardão, Adrian Velazquez-Campoy, Krzysztof Pyrc, Luca Sancineto, Claudio Santi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 7048 (2021)
The development of new antiviral drugs against SARS-CoV-2 is a valuable long-term strategy to protect the global population from the COVID-19 pandemic complementary to the vaccination. Considering this, the viral main protease (Mpro) is among the mos
Externí odkaz:
https://doaj.org/article/c7d9660954664d04a1e48134cbfc386c
Autor:
Bruno Rizzuti, Fedora Grande, Filomena Conforti, Ana Jimenez-Alesanco, Laura Ceballos-Laita, David Ortega-Alarcon, Sonia Vega, Hugh T. Reyburn, Olga Abian, Adrian Velazquez-Campoy
Publikováno v:
Biomedicines, Vol 9, Iss 4, p 375 (2021)
The pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has stimulated the search for antivirals to tackle COVID-19 infection. Molecules with known pharmacokinetics and already approved for human use have been demonstrated
Externí odkaz:
https://doaj.org/article/9a466abe98f84716bd028e11b582d7f0
Autor:
David Ortega-Alarcon, Rafael Claveria-Gimeno, Sonia Vega, Olga C. Jorge-Torres, Manel Esteller, Olga Abian, Adrian Velazquez-Campoy
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1533 (2020)
Methyl-CpG binding protein 2 (MeCP2) is a transcriptional regulator and a chromatin-binding protein involved in neuronal development and maturation. Loss-of-function mutations in MeCP2 result in Rett syndrome (RTT), a neurodevelopmental disorder that
Externí odkaz:
https://doaj.org/article/0a95739694494719b4ff128e916fc048
Antiviral compounds are crucial to controlling the SARS-CoV-2 pandemic. Approved drugs have been tested for their efficacy against COVID-19, and new pharmaceuticals are being developed as a complementary tool to vaccines However, there are not any ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbd32d9e15c5bca654768b5237b6c14
http://hdl.handle.net/10261/303136
http://hdl.handle.net/10261/303136
Autor:
Margarida Bastos, Olga Abian, Christopher M. Johnson, Frederico Ferreira-da-Silva, Sonia Vega, Ana Jimenez-Alesanco, David Ortega-Alarcon, Adrian Velazquez-Campoy
Publikováno v:
Nature Reviews Methods Primers. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dda1d6a1ab17f5838f85129709a74fff
https://doi.org/10.1038/s43586-023-00199-x
https://doi.org/10.1038/s43586-023-00199-x