Zobrazeno 1 - 10
of 48
pro vyhledávání: '"David Orain"'
Autor:
Florence Ecoeur, Jessica Weiss, Klemens Kaupmann, Samuel Hintermann, David Orain, Christine Guntermann
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The nuclear hormone receptor retinoic acid receptor-related-orphan-receptor-gamma t (RORγt) is the key transcription factor required for Th17 cell differentiation and for production of IL-17 family cytokines by innate and adaptive immune cells. Dysr
Externí odkaz:
https://doaj.org/article/2ae3c3ad1f7f4e38aa8ddb45487cc657
Autor:
Ulf Guendisch, Jessica Weiss, Florence Ecoeur, Julia Christina Riker, Klemens Kaupmann, Joerg Kallen, Samuel Hintermann, David Orain, Janet Dawson, Andreas Billich, Christine Guntermann
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188391 (2017)
Retinoic acid receptor-related-orphan-receptor-C (RORγt) is the key transcription factor that is driving the differentiation of IL-17 producing T-helper 17 (Th17) cells that are implicated in the pathology of various autoimmune and inflammatory dise
Externí odkaz:
https://doaj.org/article/6839b528280445038584f573c6fe3d0d
Publikováno v:
CHIMIA, Vol 57, Iss 5 (2003)
The core structure of a natural product was selected as scaffold for combinatorial library synthesis. The key step for the construction of the 3,9-diazabicyclo[3.3.1]non-6-ene core is a novel Dakin-West/Pictet-Spengler reaction sequence. Route select
Externí odkaz:
https://doaj.org/article/9e86f75ca86c435b92e6287ef7b3b734
Autor:
Christine Guntermann, Janet Dawson, Anna Vulpetti, Andreas Billich, Rowan Stringer, Johannes Ottl, Samuel Hintermann, Henri Mattes, Eric Vangrevelinghe, Nigel Graham Cooke, Klemens Kaupmann, Romain M. Wolf, Juergen Wagner, Klemens Hoegenauer, Joerg Kallen, David Orain, David Carcache
Publikováno v:
Journal of Medicinal Chemistry. 61:6724-6735
The transcription factor RORγt is an attractive drug-target due to its role in the differentiation of IL-17 producing Th17 cells that play a critical role in the etiopathology of several autoimmune diseases. Identification of starting points for ROR
Autor:
Klaus Weigand, Andrea Vaupel, Roland Feifel, Berndt Oberhauser, Janet Dawson King, Mark Nash, Pius Loetscher, Amanda Littlewood-Evans, David Orain, Wolfgang Miltz, Juraj Velcicky
Publikováno v:
Journal of Medicinal Chemistry. 60:3672-3683
A novel, selective, and efficacious GPR4 antagonist 13 was developed starting from lead compound 1a. While compound 1a showed promising efficacy in several disease models, its binding to a H3 receptor as well as a hERG channel prevented it from furth
Autor:
Christine Guntermann, Juergen Wagner, David Orain, Andreas Billich, Joerg Kallen, Samuel Hintermann, Janet Dawson, Rowan Stringer, Henri Mattes, Klemens Kaupmann, David Carcache, Anna Vulpetti
Publikováno v:
ChemMedChem. 11:2640-2648
Retinoic-acid-related orphan receptor γt (RORγt) is a key transcription factor implicated in the production of pro-inflammatory Th17 cytokines, which drive a number of autoimmune diseases. Despite diverse chemical series having been reported, combi
Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist
Autor:
David Orain, Kurt Lingenhoehl, Sandrine Desrayaud, David Carcache, Joerg Kallen, Anne Picard, Stephan Urwyler, Phillip Floersheim, Engin Tasdelen, Manuel Koller, Celine Dubois, Samuel Haessig, Henri Mattes
Publikováno v:
ChemMedChem. 12:197-201
A series of potent quinazolinedione sulfonamide antagonists of the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor were designed and synthesized. The structure-activity relationships (SAR) and in vivo activity of the series wer
Autor:
David Orain, Christine Guntermann, Samuel Hintermann, Jessica Weiss, Florence Ecoeur, Julia Christina Riker, Janet Dawson, Ulf Guendisch, Andreas Billich, Joerg Kallen, Klemens Kaupmann
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0188391 (2017)
PLoS ONE, Vol 12, Iss 11, p e0188391 (2017)
Retinoic acid receptor-related-orphan-receptor-C (RORγt) is the key transcription factor that is driving the differentiation of IL-17 producing T-helper 17 (Th17) cells that are implicated in the pathology of various autoimmune and inflammatory dise
Publikováno v:
Synlett. 26:1815-1818
A novel and efficient synthesis of orthogonally protected spirocyclic amines is described for the first time.
Autor:
Christine Guntermann, Joerg Kallen, David Orain, Klemens Hoegenauer, Klemens Kaupmann, Celine Be, Samuel Hintermann, Aude Izaac, Luca Arista
Publikováno v:
ChemMedChem. 12(13)
The T-cell-specific retinoic acid receptor (RAR)-related orphan receptor-γ (RORγt) is a key transcription factor for the production of pro-inflammatory Th17 cytokines, which are implicated in the pathogenesis of autoimmune diseases. Over the years,