Zobrazeno 1 - 10
of 207
pro vyhledávání: '"David O. Morgan"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The authors used novel single-molecule technology to measure the affinity of interactions between the ubiquitin ligase APC/C and its substrates, providing insights into the control of APC/C substrate destruction during mitosis.
Externí odkaz:
https://doaj.org/article/e7d8f08955e54071893dc443e997af0d
Autor:
Arda Mizrak, David O. Morgan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Activation of APC/C depends on transient interactions with an activator subunit. Here, the authors show that cellular polyanions trigger APC/C-activator dissociation and that high-affinity substrates block this effect, suggesting that substrate avail
Externí odkaz:
https://doaj.org/article/869fdb2adcb8456499a4ef87da848460
Autor:
Laura E. Rosen, Joseph E. Klebba, Jonathan B. Asfaha, Chloe M. Ghent, Melody G. Campbell, Yifan Cheng, David O. Morgan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Prior to anaphase, securin binds separase and thereby prevents cohesin cleavage. Here, the authors develop a method to produce active securin-free separase, identify a docking motif in cohesin that promotes cleavage, and show that securin interferes
Externí odkaz:
https://doaj.org/article/0aa2e46a831d4778b0b71ae518c06875
Publikováno v:
Biology Open, Vol 3, Iss 10, Pp 904-912 (2014)
The Anaphase Promoting Complex or Cyclosome (APC/C) is critical to the control of mitosis. The APC/C is an ubiquitin ligase that targets specific mitotic regulators for proteolysis at distinct times in mitosis, but how this is achieved is not well un
Externí odkaz:
https://doaj.org/article/619343418e474cf89be1005b3d6be8bf
Publikováno v:
Biochemical Society Transactions.
Sister chromatid segregation is the final irreversible step of mitosis. It is initiated by a complex regulatory system that ultimately triggers the timely activation of a conserved cysteine protease named separase. Separase cleaves the cohesin protei
The nucleocapsid (N) protein of coronaviruses is responsible for compaction of the ∼30-kb RNA genome in the ∼100-nm virion. Cryo-electron tomography suggests that each virion contains 35-40 viral ribonucleoprotein (vRNP) complexes, or ribonucleos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35889ba3b5ba430cf5ab0b2ae3b034d9
https://doi.org/10.1101/2022.05.23.493138
https://doi.org/10.1101/2022.05.23.493138
Autor:
Mihkel Örd, Mart Loog, David O. Morgan, Jonathan B. Asfaha, Christopher R. Carlson, Ilona Faustova
Publikováno v:
Current biology : CB, vol 32, iss 1
Curr Biol
bioRxiv
Curr Biol
bioRxiv
SummaryCell-cycle progression is driven by the phosphorylation of cyclin-dependent kinase (Cdk) substrates1–3. The order of substrate phosphorylation depends in part on the general rise in Cdk activity during the cell cycle4–7, together with vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a6fe378168c4dccd7529f50f277563
https://escholarship.org/uc/item/40g2p35s
https://escholarship.org/uc/item/40g2p35s
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Nature communications, vol 13, iss 1
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Nature communications, vol 13, iss 1
Robust regulatory signals in the cell often depend on interactions between short linear motifs (SLiMs) and globular proteins. Many of these interactions are poorly characterized because the binding proteins cannot be produced in the amounts needed fo
Robust regulatory signals in the cell often depend on interactions between short linear motifs (SLiMs) and globular proteins. Many of these interactions are poorly characterized because the binding proteins cannot be produced in the amounts needed fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a01642cfc9a128d6def21037bb46e720
https://doi.org/10.1101/2021.09.25.461797
https://doi.org/10.1101/2021.09.25.461797
Autor:
Yashar Sadian, Tobias Raisch, David Barford, Pramod M Sabale, Chloe M. Ghent, Pierre Raia, Simone Cavadini, Andreas Boland, Jun Yu, David O. Morgan, Stefan Raunser
Publikováno v:
Nature
In early mitosis, the duplicated chromosomes are held together by the ring-shaped cohesin complex1. Separation of chromosomes during anaphase is triggered by separase—a large cysteine endopeptidase that cleaves the cohesin subunit SCC1 (also known