Výsledky vyhledávání - "David O. Callagaro"

Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity of N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine

Autor: G. Erik Jagdmann, Joseph P. Tizzano, David O. Callagaro, Darryle D. Schoepp, Michael P. Johnson, Thomas H. Large, James A. Monn, Thomas C. Britton, Melvyn Baez

Publikováno v: Journal of Medicinal Chemistry. 46:3189-3192

This report describes recently discovered novel allosteric modulators of metabotropic glutamate2 (mGlu2) receptors. These pyridylmethylsulfonamides (e.g., 3) potentiate glutamate, shifting agonist potency by 2-fold. This effect was specific for mGlu2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cfce582d17cc9ab1d5c4038c66071f
https://doi.org/10.1021/jm034015u

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