Zobrazeno 1 - 10
of 276
pro vyhledávání: '"David O Bates"'
Autor:
Monica Gamez, Hesham E. Elhegni, Sarah Fawaz, Kwan Ho Ho, Neill W. Campbell, David A. Copland, Karen L. Onions, Matthew J. Butler, Elizabeth J. Wasson, Michael Crompton, Raina D. Ramnath, Yan Qiu, Yu Yamaguchi, Kenton P. Arkill, David O. Bates, Jeremy E. Turnbull, Olga V. Zubkova, Gavin I. Welsh, Denize Atan, Simon C. Satchell, Rebecca R. Foster
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Background Diabetes mellitus is a chronic disease which is detrimental to cardiovascular health, often leading to secondary microvascular complications, with huge global health implications. Therapeutic interventions that can be applied to m
Externí odkaz:
https://doaj.org/article/330be12c4f514058b4ffcf2e9c2f0251
Autor:
David O Bates, Athina Mavrou, Yan Qiu, James G Carter, Maryam Hamdollah-Zadeh, Shaney Barratt, Melissa V Gammons, Ann B Millar, Andrew H J Salmon, Sebastian Oltean, Steven J Harper
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68399 (2013)
Vascular Endothelial Growth Factor-A (VEGF-A) can be generated as multiple isoforms by alternative splicing. Two families of isoforms have been described in humans, pro-angiogenic isoforms typified by VEGF-A165a, and anti-angiogenic isoforms typified
Externí odkaz:
https://doaj.org/article/c5e11b23554f49f3992873cd602d0d0f
Autor:
Kyaw Zwar Myint, Mireia Sueca-Comes, Pamela Collier, Brinda Balasubramanian, Simran Venkatraman, John Gordan, Abed M. Zaitoun, Abhik Mukherjee, Arvind Arora, Noppadol Larbcharoensub, Chinnawut Suriyonplengsaeng, Kanokpan Wongprasert, Tavan Janvilisri, Dhanny Gomez, Anna M. Grabowska, Rutaiwan Tohtong, David O. Bates, Kiren Yacqub-Usman
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionBile duct cancer (cholangiocarcinoma, CCA) has a poor prognosis for patients, and despite recent advances in targeted therapies for other cancer types, it is still treated with standard chemotherapy. Anaplastic lymphoma kinase (ALK) has b
Externí odkaz:
https://doaj.org/article/169ad49512ff4bd2ae8d553a1e4dd8f5
Autor:
Michael A. Portelli, Sangita Bhaker, Vincent Pang, David O. Bates, Simon R. Johnson, Andrew P. Mazar, Dominick Shaw, Christopher Brightling, Ian Sayers
Publikováno v:
Clinical and Translational Allergy, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown. Object
Externí odkaz:
https://doaj.org/article/b98b2138b6a345bba5e4c156f9115f19
Autor:
Roaa H. Alalwany, Tom Hawtrey, Kevin Morgan, Jonathan C. Morris, Lucy F. Donaldson, David O. Bates
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Alzheimer’s disease (AD) is the most common cause of dementia, the chronic and progressive deterioration of memory and cognitive abilities. AD can be pathologically characterised by neuritic plaques and neurofibrillary tangles, formed by the aberra
Externí odkaz:
https://doaj.org/article/440c5e871b4a4cc58d6172dcaed53313
Autor:
Monica Gamez, Hesham E. Elhegni, Sarah Fawaz, Kwan Ho Ho, Neill W. Campbell, David A. Copland, Karen L. Onions, Matthew J. Butler, Elizabeth J. Wasson, Michael Crompton, Raina D. Ramnath, Yan Qiu, Yu Yamaguchi, Kenton P. Arkill, David O. Bates, Jeremy E. Turnbull, Olga V. Zubkova, Gavin I. Welsh, Denize Atan, Simon C. Satchell, Rebecca R. Foster
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/1958e1ee5d4b47d2a70284f0b87673c4
Autor:
Kyaw Zwar Myint, Brinda Balasubramanian, Simran Venkatraman, Suchada Phimsen, Supisara Sripramote, Jeranan Jantra, Chaiwat Choeiphuk, Somkit Mingphruedhi, Paramin Muangkaew, Narongsak Rungsakulkij, Pongsatorn Tangtawee, Wikran Suragul, Watoo Vassanasiri Farquharson, Kanokpan Wongprasert, Somchai Chutipongtanate, Pimtip Sanvarinda, Marisa Ponpuak, Naravat Poungvarin, Tavan Janvilisri, Tuangporn Suthiphongchai, Kiren Yacqub-Usman, Anna M. Grabowska, David O. Bates, Rutaiwan Tohtong
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 197 (2024)
Cholangiocarcinoma (CCA) is a difficult-to-treat cancer, with limited therapeutic options and surgery being the only curative treatment. Standard chemotherapy involves gemcitabine-based therapies combined with cisplatin, oxaliplatin, capecitabine, or
Externí odkaz:
https://doaj.org/article/61c5f9c5650f4995b33765a79df28a4a
Autor:
Jinchutha Duangdara, Boonyakorn Boonsri, Apinya Sayinta, Kittiya Supradit, Pakpoom Thintharua, Supeecha Kumkate, Chinnawut Suriyonplengsaeng, Noppadol Larbcharoensub, Somkit Mingphruedhi, Narongsak Rungsakulkij, Paramin Muangkaew, Pongsatorn Tangtawee, Watoo Vassanasiri, Wikran Suragul, Tavan Janvilisri, Rutaiwan Tohtong, David O. Bates, Kanokpan Wongprasert
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 9 (2023)
Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) play essential roles in promoting cholangiocarcinoma (CCA) cell survival by mediating paracrine crosstalk between tumor and cancer-associated fibroblasts (CAFs), indicating the poten
Externí odkaz:
https://doaj.org/article/cb30564eb065479f9a10b008793cc418
Autor:
Eleanor Star, Megan Stevens, Clare Gooding, Christopher W. J. Smith, Ling Li, Monica Lamici Ayine, Steve J. Harper, David O. Bates, Sebastian Oltean
Publikováno v:
Oncogenesis, Vol 10, Iss 5, Pp 1-12 (2021)
Abstract Alternative splicing of the vascular endothelial growth factor A (VEGF-A) terminal exon generates two protein families with differing functions. Pro-angiogenic VEGF-Axxxa isoforms are produced via selection of the proximal 3′ splice site o
Externí odkaz:
https://doaj.org/article/b2b9f454833f4965855002d89dcada06
Hydrogen Sulfide Is a Novel Protector of the Retinal Glycocalyx and Endothelial Permeability Barrier
Autor:
Claire L. Allen, Katarzyna Wolanska, Naseeb K. Malhi, Andrew V. Benest, Mark E. Wood, Winfried Amoaku, Roberta Torregrossa, Matthew Whiteman, David O. Bates, Jacqueline L. Whatmore
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Significantly reduced levels of the anti-inflammatory gaseous transmitter hydrogen sulfide (H2S) are observed in diabetic patients and correlate with microvascular dysfunction. H2S may protect the microvasculature by preventing loss of the endothelia
Externí odkaz:
https://doaj.org/article/045343c009d94e33ab351eef1c22e116