Zobrazeno 1 - 10
of 453
pro vyhledávání: '"David O'Hagan"'
Publikováno v:
IUCrData, Vol 8, Iss 4, p x230300 (2023)
A new isoxazole-based iodonoium salt, C13H13INO5+·C2F3O2−, has been synthesized and structurally characterized. In the crystal, ions are linked by short I...O contacts to form a neutral tetra-ion aggregate. These combine with C—H...F and C—H..
Externí odkaz:
https://doaj.org/article/afac430608a446a7a7d35be5a5c586ff
Autor:
Tiia Kittilä, Patricia Calero, Folmer Fredslund, Phillip T. Lowe, David Tezé, Manuel Nieto‐Domínguez, David O’Hagan, Pablo I. Nikel, Ditte H. Welner
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 5, Pp 1622-1632 (2022)
Summary The fluorinase enzyme represents the only biological mechanism capable of forming stable C–F bonds characterized in nature thus far, offering a biotechnological route to the biosynthesis of value‐added organofluorines. The fluorinase is k
Externí odkaz:
https://doaj.org/article/30a605b318914efbbf5a7a77aa635e6c
Autor:
Patricia Calero, Daniel C. Volke, Phillip T. Lowe, Charlotte H. Gotfredsen, David O’Hagan, Pablo I. Nikel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Addition of fluorine to organic structures is a unique strategy for tuning molecular properties, but approaches to integrate fluorometabolites into the biochemistry of living cells are scarce. Here, the authors develop a fluoride-responsive genetic c
Externí odkaz:
https://doaj.org/article/1a6013c572344c6f92fbaa1ff47e21f1
Autor:
Zeguo Fang, Nawaf Al-Maharik, Peer Kirsch, Matthias Bremer, Alexandra M. Z. Slawin, David O’Hagan
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 674-680 (2020)
This paper describes the synthesis of a series of organic liquid crystals (LCs) containing selectively fluorinated cyclopropanes at their termini. The syntheses used difluorocarbene additions to olefin precursors, an approach which proved straightfor
Externí odkaz:
https://doaj.org/article/f688a8e36afa4f89b9f69cf178810115
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 1441-1447 (2019)
We report the metabolism of the recently introduced α,α-difluoroethyl thioether motif to explore further its potential as a substituent for bioactives discovery chemistry. Incubation of two aryl–SCF2CH3 ethers with the model yeast organism Cunnin
Externí odkaz:
https://doaj.org/article/f472c82d982e40fa80b649abe58c69f7
Autor:
Neil S. Keddie, Pier Alexandre Champagne, Justine Desroches, Jean-François Paquin, David O'Hagan
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 106-113 (2018)
In recent years, the highly polar C–F bond has been utilised in activation chemistry despite its low reactivity to traditional nucleophiles, when compared to other C–X halogen bonds. Paquin’s group has reported extensive studies on the C–F ac
Externí odkaz:
https://doaj.org/article/973a1210e2264aaebefcc969cde13578
Autor:
David O’Hagan
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 737-738 (2021)
Externí odkaz:
https://doaj.org/article/ea56a1e1ef7e41f9994ee156ed8e4af5
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 728-733 (2017)
This paper reports the synthesis of three amine stereoisomers 5a–c of the tetrafluorocyclohexyl ring system, as building blocks for discovery chemistry programmes. The synthesis starts from a Birch reduction of benzonitrile, followed by an in situ
Externí odkaz:
https://doaj.org/article/60d6e491642442f88ea2cba76bdcaa02
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2823-2827 (2016)
2,2-Dimethyl-5-phenyl-1,1,3,3-tetrafluororocyclohexane has been prepared and characterised as an example of a facially polarised cyclohexane containing 1,3 related CF2 groups. The dipolar nature of the ring arises from the axial orientation of two of
Externí odkaz:
https://doaj.org/article/79f613df87e94c67a39bab366383ade2
Autor:
Shigeyuki Yamada, Yizhou Wang, Masato Morita, Qingzhi Zhang, David O’Hagan, Masakazu Nagata, Tomohiro Agou, Hiroki Fukumoto, Toshio Kubota, Mitsuo Hara, Tsutomu Konno
Publikováno v:
Crystals, Vol 11, Iss 4, p 450 (2021)
Photoluminescent liquid crystals (PLLCs) have attracted significant attention owing to their broad applicability in thermosensing and PL switching. Extensive efforts have been made to develop bistolane-based PLLCs containing flexible units at both mo
Externí odkaz:
https://doaj.org/article/c534a2c1ac904556924bacf8b06efc57