Zobrazeno 1 - 10
of 180
pro vyhledávání: '"David Norton"'
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Whole genome analysis of a novel species of enterococci, Enterococcus lacertideformus, causing multi-systemic and invariably fatal disease in critically endangered Christmas Island reptiles was undertaken to determine the genetic elements and potenti
Externí odkaz:
https://doaj.org/article/e55ae49e80854bfd92079baf12630db5
Autor:
Francla J. Gouillart, David Norton
Publikováno v:
RAE: Revista de Administração de Empresas, Vol 35, Iss 2 (1995)
A Reengenharía é apenas um sub-set da Transformação. Mais do que um redesenho de processos individuais - frequentemente com ajuda de benchmarking -, a Transformação é o redesenho simultâneo e integrado de vários processos e sistemas.
Externí odkaz:
https://doaj.org/article/ee85fd3fa50e4810b5df031508d959dc
Autor:
David Norton
The King James Bible was the result of an extraordinary effort over nearly a century to make many good English translations and turn them into what the translators called'one principal good one, not justly to be excepted against'. David Norton traces
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary tables 1-6 summarise the kinase panel screen data (1) mouse PK parameters (2) and further details of the anti-tumour activity (5) conferred by ASTX029, plus details of cell lines used in this study (3 and 4) and further details of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c83a97aa3dd2ed35fbdc9ef36e9bb5
https://doi.org/10.1158/1535-7163.22521489.v1
https://doi.org/10.1158/1535-7163.22521489.v1
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary figures 1-7 show the effects of AST029 on ERK signalling in RAS-mutant cell lines (1) and tumour xenograft tissue (3), ASTX029 plasma PK linearity (2), ASTX029 activity in a cell line panel showing MAPK mutation status (4) the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185aef78c19fca4a606a8b2c178f1341
https://doi.org/10.1158/1535-7163.22521498.v1
https://doi.org/10.1158/1535-7163.22521498.v1
Autor:
Caroline Richardson, Zining Wu, Henriëtte M. G. Willems, William E. Wixted, Alison Jo-Anne Woolford, Charlotte Mary Griffiths-Jones, Yolanda Sanchez, David Norton, Jeffrey K. Kerns, T.G. Davies, William G. Bonnette, Sharna J. Rich, James F. Callahan, Hong Nie, Lawrence Wolfe, Maria Grazia Carr, Marcel L. Verdonk, William L. Rumsey, Tom D. Heightman
Publikováno v:
Journal of Medicinal Chemistry. 64:15949-15972
The NRF2-mediated cytoprotective response is central to cellular homoeostasis, and there is increasing interest in developing small-molecule activators of this pathway as therapeutics for diseases involving chronic oxidative stress. The protein KEAP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba196f8cf42319174247f8aba6d5c760
https://doi.org/10.1021/acs.jmedchem.1c01351
https://doi.org/10.1021/acs.jmedchem.1c01351
Autor:
Bradley Case, Adam Forbes, Margaret Stanley, Graham Hinchcliffe, David Norton, Febyanna Suryaningrum, Rebecca Jarvis, David Hall, Hannah Buckley
Publikováno v:
New Zealand Journal of Ecology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::012cf3ef544ea097ef0e0e61bec49ffa
https://doi.org/10.20417/nzjecol.47.3504
https://doi.org/10.20417/nzjecol.47.3504
Autor:
Neil T. Thompson, Nicola G. Wallis, Michael Reader, Christopher J. Hindley, Juan Castro, John Lyons, David C. Rees, Nicola E. Wilsher, Caroline Richardson, Tom D. Heightman, Lukas Stanczuk, Alpesh Shah, Sharna J. Rich, Charlotte East, Valerio Berdini, Marc O'Reilly, Justyna Kucia-Tran, Jessica L. Brothwood, Joanne M. Munck, Alison Jo-Anne Woolford, Sandra Muench, Christopher William Murray, David Norton, Luke Bevan, Aurélie Courtin, Roberta Ferraldeschi, Vanessa Martins
Publikováno v:
Molecular Cancer Therapeutics. 20:1757-1768
The MAPK signaling pathway is commonly upregulated in human cancers. As the primary downstream effector of the MAPK pathway, ERK is an attractive therapeutic target for the treatment of MAPK-activated cancers and for overcoming resistance to upstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6856599564530823950e091fd6e69a67
https://doi.org/10.1158/1535-7163.mct-20-0909
https://doi.org/10.1158/1535-7163.mct-20-0909
Autor:
David Norton
Revised and condensed from David Norton's acclaimed A History of the Bible as Literature, this book, first published in 2000, tells the story of English literary attitudes to the Bible. At first jeered at and mocked as English writing, then denigrate