Zobrazeno 1 - 10
of 105
pro vyhledávání: '"David Neuhaus"'
Autor:
Leo Kiss, Tyler Rhinesmith, Jakub Luptak, Claire F. Dickson, Jonas Weidenhausen, Shannon Smyly, Ji-Chun Yang, Sarah L. Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C. James
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract TRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular antibody receptor TRIM21, which is responsible for mediating targeted protein degradation during Trim-Away. Despite their importance, the ubiquitin
Externí odkaz:
https://doaj.org/article/9847497c03534f53b81f80ff92484d91
Autor:
Anna Sefer, Eleni Kallis, Tobias Eilert, Carlheinz Röcker, Olga Kolesnikova, David Neuhaus, Sebastian Eustermann, Jens Michaelis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Sm FRET studies of PARP-1 recognition of DNA lesion show that binding of F1F2 fragment results in a kinked DNA, while binding of F2 fragment alone yields an intermediate state. This dynamic equilibrium of states is influenced by inhibitors.
Externí odkaz:
https://doaj.org/article/642a60ff46824c648ef3c679a670721e
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The mechanism by which RING E3-anchored ubiquitin chains are formed is not well understood. Here, the authors solve a crystal structure of the RING E3 enzyme TRIM21 trapped in the process of self-anchored chain elongation and provide biochemical and
Externí odkaz:
https://doaj.org/article/0f644432debf47e98e75f25c8144c7a6
Autor:
Harriet Crawley-Snowdon, Ji-Chun Yang, Nathan R. Zaccai, Luther J. Davis, Lena Wartosch, Emily K. Herman, Nicholas A. Bright, James S. Swarbrick, Brett M. Collins, Lauren P. Jackson, Matthew N. J. Seaman, J. Paul Luzio, Joel B. Dacks, David Neuhaus, David J. Owen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
VARP is bound to endosomes and functions as a protein:protein interaction platform. Here, the authors present the NMR structure of the complex between the retromer subunit VPS29 and a VARP Zn-fingernail microdomain that is structurally distinct from
Externí odkaz:
https://doaj.org/article/5179c14a82ba4080bfd7a8f14df6270f
Autor:
Leo Kiss, Jingwei Zeng, Claire F. Dickson, Donna L. Mallery, Ji-Chun Yang, Stephen H. McLaughlin, Andreas Boland, David Neuhaus, Leo C. James
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The E3 ligase TRIM21 targets a broad range of pathogenic proteins using a unique mechanism. Here, the authors combine structural, biochemical and cell biological approaches to elucidate how TRIM21 selectively recruits its canonical E2 partner enzyme
Externí odkaz:
https://doaj.org/article/470293ee22be4d32ba89b9430667e524
Autor:
Claire Dickson, Adam J Fletcher, Marina Vaysburd, Ji-Chun Yang, Donna L Mallery, Jingwei Zeng, Christopher M Johnson, Stephen H McLaughlin, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W Chin, David Neuhaus, Leo C James
Publikováno v:
eLife, Vol 7 (2018)
Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but how this is regulated is unknow
Externí odkaz:
https://doaj.org/article/5202b947b0ec499ebb78db70bf28d54e
Autor:
Leo Kiss, Tyler Rhinesmith, Claire F Dickson, Jonas Weidenhausen, Shannon Smyly, Jakub Luptak, Ji-Chun Yang, Sarah L Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C James
TRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular antibody receptor TRIM21, which is responsible for mediating targeted protein degradation during Trim-Away. Despite their importance, the ubiquitination mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ff087e88dc61ef593889cbe848b8038
https://doi.org/10.1101/2022.06.29.498105
https://doi.org/10.1101/2022.06.29.498105
Autor:
Marie-France Langelier, Michael McCauley, Elizabeth Underwood, Laura E. Easton, Ji-Chun Yang, David Neuhaus, Kevin J. Embrey, Philip B. Rawlins, John M. Pascal, Marianne Schimpl, Tom E. H. Ogden
Publikováno v:
Nucleic Acids Research
PARP-1 is a key early responder to DNA damage in eukaryotic cells. An allosteric mechanism links initial sensing of DNA single-strand breaks by PARP-1’s F1 and F2 domains via a process of further domain assembly to activation of the catalytic domai
Autor:
J. Paul Luzio, Brett M. Collins, Nicholas A. Bright, Joel B. Dacks, James S. Swarbrick, Lena Wartosch, Harriet Crawley-Snowdon, Ji-Chun Yang, Luther J. Davis, Nathan R. Zaccai, Lauren P. Jackson, David J. Owen, Matthew N.J. Seaman, David Neuhaus, Emily K. Herman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Funder: Discovery Grants from the Natural Sciences and Engineering Research Council of Canada (RES0043758, RES0046091)
VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retrograde trafficking from endosomes. Using an NMR/X-r
VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retrograde trafficking from endosomes. Using an NMR/X-r
Autor:
David Neuhaus
Publikováno v:
Progress in nuclear magnetic resonance spectroscopy.
Zinc fingers can be loosely defined as protein domains containing one or more tetrahedrally-co-ordinated zinc ions whose role is to stabilise the structure rather than to be involved in enzymatic chemistry; such zinc ions are often referred to as "st