Zobrazeno 1 - 10
of 58
pro vyhledávání: '"David Nettleton"'
Autor:
David Nettleton
Whether you are brand new to data mining or working on your tenth predictive analytics project, Commercial Data Mining will be there for you as an accessible reference outlining the entire process and related themes. In this book, you'll learn that y
Autor:
Daniel Wall, Charles Babu, Tejas P. Pathak, Swastik Phulera, Qin Hao, Piro Siuti, Christopher J. Schwalen, David Nettleton
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 44, Pp 29555-29566 (2021)
ACS Omega, Vol 6, Iss 44, Pp 29555-29566 (2021)
Knotted peptides present a wealth of structurally diverse, biologically active molecules, with the inhibitor cystine knot/knottin class among the most ecologically common ones. Many of these natural products interact with extracellular targets such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e42f9aca80e4f7dee7781d771c8a04
http://europepmc.org/articles/PMC8582066
http://europepmc.org/articles/PMC8582066
Publikováno v:
Proceedings of the International AAAI Conference on Web and Social Media. 5:610-613
User influence is an important topic of research for online social networks. Recent work has shown that a user's influence is not directly related with node in-degree. However, the definition of what is an influential or relevant user is still an ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ae8352af88be06ff6657daad63a9186
https://doi.org/10.1609/icwsm.v5i1.14164
https://doi.org/10.1609/icwsm.v5i1.14164
Autor:
Laurie P Volak, Heide Marika Duevel, Sara Humphreys, David Nettleton, Colin Phipps, Andy Pike, Caroline Rynn, Paul Scott-Stevens, Donglu Zhang, Michael Zientek
Publikováno v:
Drug Metabolism and Disposition. :DMD-AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15157c684e786e7379b9c06455c45b7c
https://doi.org/10.1124/dmd.122.001154
https://doi.org/10.1124/dmd.122.001154
Autor:
Christian M. Gampe, Jingzhou Li, Patel Tajesh Jayprakash, Jakal Amin, Charles Babu, Lihua Yang, Eugene Liu, Andrei Golosov, Katsumasa Nakajima, David Nettleton, Patrick C. Reid, Lauren G. Monovich, Flyer Alec
Publikováno v:
Journal of Medicinal Chemistry. 64:2622-2633
Advances in the design of permeable peptides and in the synthesis of large arrays of macrocyclic peptides with diverse amino acids have evolved on parallel but independent tracks. Less precedent combines their respective attributes, thereby limiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dd9795db77b2153f204b31c1dd80d9
https://doi.org/10.1021/acs.jmedchem.0c01505
https://doi.org/10.1021/acs.jmedchem.0c01505
Autor:
Margaret E Brousseau, Kevin B Clairmont, Glen Spraggon, Alec N Flyer, Andrei A Golosov, Philipp Grosche, Jérôme André, Shari Caplan, Guanjing Chen, Li Fan, Raphael Gattlen, Alexander Koch, Ian Lewis, Jingzhou Li, Eugene Liu, Danuta Lubicka, Andreas Marzinzik, Katsumasa Nakajima, David Nettleton, Johannes Ottl, Meihui Pan, Tajesh Patel, Stephanie Pickett, Jennifer Poirier, Patrick C Reid, Xavier Pelle, Vanitha Subramanian, Victoria Vera, Mei Xu, Lihua Yang, Qing Yang, jinghua yu, Guoming Zhu, Lauren G Monovich
Publikováno v:
Circulation. 144
Elevated LDL-C is a major risk factor for atherosclerotic cardiovascular disease, the leading cause of death worldwide. Proprotein convertase subtilisin/kexin type 9 (PCSK9) has pronounced effects on LDL-C levels via its modulation of hepatic LDL rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c41fa5183540594ef99cce950597f62
https://doi.org/10.1161/circ.144.suppl_1.10516
https://doi.org/10.1161/circ.144.suppl_1.10516
Autor:
Katsumasa Nakajima, David Nettleton, Guoming Zhu, Debra Burdick, Alexander W. Koch, Qing Yang, Glen Spraggon, Margaret E. Brousseau, Guanjing Chen, Lisa Ames, Raphael Gattlen, Flyer Alec, Jennifer Poirier, Jingzhou Li, Mohindra Seepersaud, Dawn Kelly-Sullivan, Stephanie Pickett, Xavier Pelle, Lauren Perry, Raj Chopra, Jakal Amin, Jerome Andre, Danuta Lubicka, Victoria Vera, Philipp Grosche, Patel Tajesh Jayprakash, Ian Lewis, Lihua Yang, Eugene Liu, Andrei Golosov, jinghua yu, Li Fan, Patrick C. Reid, Lauren G. Monovich, Shari L. Caplan, Meihui Pan, Diana Dubiel, Vanitha Subramanian, Kevin B. Clairmont, Johannes Ottl, Mei Xu, Andreas Marzinzik
Publikováno v:
Cell Chemical Biology. 29:249-258.e5
Summary Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation. Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b646053b683b9aba0f84b9efef17df
https://doi.org/10.1016/j.chembiol.2021.08.012
https://doi.org/10.1016/j.chembiol.2021.08.012
The first examples of biologically active monocyclic 1,2-azaborines have been synthesized and demonstrated to exhibit not only improved in vitro aqueous solubility in comparison with their corresponding carbonaceous analogues, but in the context of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f5cd6d8d08eb19ef4d5419b90822ab
https://europepmc.org/articles/PMC5654323/
https://europepmc.org/articles/PMC5654323/
Publikováno v:
Revista Colombiana de Computación, Vol 13, Iss 2, Pp 53-72 (2012)
Los datos de los archivos de registro de actividades Web (Web log data) han sido la base del analisis del comportamiento de los usuarios durante muchos años, sin embargo, estos datos tienen algunos defectos importantes, el principal es que no permit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::ba8ca89f1b51615cbb9e6f2af9cea620
https://revistas.unab.edu.co/index.php/rcc/article/view/2125/1892
https://revistas.unab.edu.co/index.php/rcc/article/view/2125/1892
Autor:
Heidi J Einolf, David Nettleton
Publikováno v:
Current Topics in Medicinal Chemistry. 11:382-403
Evaluation of the potential of a drug candidate to inhibit or inactivate cytochrome P450 (CYP) enzymes remains an important part of pharmaceutical drug Discovery and Development programs. CYP enzymes are considered to be one of the most important enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b5bdd399eab9e608dd819d8e826d75
https://doi.org/10.2174/156802611794480882
https://doi.org/10.2174/156802611794480882