Zobrazeno 1 - 5
of 5
pro vyhledávání: '"David Neil Watkins"'
Autor:
Hayley S Ma, William Matsui, Donald Small, Akil Merchant, Luigi Marchionni, Mark J. Levis, Emily Chang, Li Li, Yiting Lim, David Neil Watkins, Sarah Foerster, Lukasz P. Gondek, Bruce Douglas Smith, David L. Huso, Karen McGovern, Qiuju Wang, Craig D. Peacock
Publikováno v:
Science Translational Medicine. 7
FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations resulting in constitutive kinase activity are common in acute myeloid leukemia (AML) and carry a poor prognosis. Several agents targeting FLT3 have been developed, but thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71fa55311060c04a821823ac88249bfe
https://doi.org/10.1126/scitranslmed.aaa5731
https://doi.org/10.1126/scitranslmed.aaa5731
Publikováno v:
Clinical & Experimental Allergy. 32:571-577
BACKGROUND The bronchial epithelium is exposed to reactive oxygen species (ROS) derived from cigarette smoke, air pollutants and activated leucocytes. Glutathione (GSH) prevents ROS-mediated loss of cell function, tissue injury and inflammation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec72f4486e9bcf96024c4845dceeab4c
https://doi.org/10.1046/j.0954-7894.2002.01294.x
https://doi.org/10.1046/j.0954-7894.2002.01294.x
Autor:
David Neil Watkins, James G. Herman, H-C Tsai, Wei Zhang, Xiaobei Zeng, Ray-Whay Chiu Yen, Gregory S Gesell, Stephen B. Baylin, Robert Beaty, Kimberley J Briggs, Brian W. Simons, M A Tyler, Ying Ye
The tumor suppressor gene hypermethylated in cancer 1 (HIC1), which encodes a transcriptional repressor, is epigenetically inactivated in various human cancers. In this study, we show that HIC1 is a direct transcriptional repressor of the gene encodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12a7205feb0b32681babab005b46bbd
https://europepmc.org/articles/PMC3025282/
https://europepmc.org/articles/PMC3025282/
Autor:
Jason E. Cain, Stephen B. Baylin, Lisa McKenzie, Samantha Jayesekara, Fernando J. Rossello, David Neil Watkins, Prue Russell, Gavin M. Wright, Anette Szczepny
Publikováno v:
Cancer Research. 74:LB-81
HIC1 is a zinc-finger transcriptional repressor frequently targeted for deletion and/or epigenetic gene silencing in cancer. In cancer cell lines, re-expression of HIC1 results in the downregulation of target genes thought to promote context-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f09bb9b11826f6032fd5b0e5d31a79f
https://doi.org/10.1158/1538-7445.am2014-lb-81
https://doi.org/10.1158/1538-7445.am2014-lb-81
Autor:
Helai P. Mohammad, James G. Herman, David L. Huso, Benjamin Leadem, Minsi Zhang, Wei Zhang, Baktiar O. Karim, Helen Selonick, David Neil Watkins, Craig M. Hooker, Stephen B. Baylin
Publikováno v:
Cancer Research. 70:LB-92
Mutations in the Adenomatous Polyposis Colt (APC) gene have been implicated both in familial as well as sporadic gastrointestinal (GI) cancers. APC mutations are associated with autosomal dominant inheritance of disease in humans. Similarly, mice tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c78d306c388b02642216895af2872058
https://doi.org/10.1158/1538-7445.am10-lb-92
https://doi.org/10.1158/1538-7445.am10-lb-92