Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David N. Saenz"'
Autor:
Yimin Qian, Warren Fiskus, Christopher P. Mill, David N. Saenz, John H. Bushweller, Tapan M. Kadia, Cristian Coarfa, Dyana T. Saenz, Kanak Raina, Andrew Futreal, Kimal Rajapakshe, Koichi Takahashi, Anuradha Illendula, Michael R. Green, Kapil N. Bhalla, Courtney D. DiNardo, Steven M. Kornblau, Craig M. Crews, Dimuthu Perera, Joseph D. Khoury
Publikováno v:
Blood
RUNX1 transcription factor regulates normal and malignant hematopoiesis. Somatic or germline mutant RUNX1 (mtRUNX1) is associated with poorer outcome in acute myeloid leukemia (AML). Knockdown or inhibition of RUNX1 induced more apoptosis of AML expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2dbd781ff7737120c5745ca6f768cf
https://doi.org/10.1182/blood.2018893982
https://doi.org/10.1182/blood.2018893982
Autor:
Christopher P. Mill, Prithviraj Bose, Yu Shen, Cristian Coarfa, Tapan M. Kadia, Gautam Borthakur, Dyana T. Saenz, Lucia Masarova, Baohua Sun, Kapil N. Bhalla, Courtney D. DiNardo, David N. Saenz, Kimal Rajapakshe, Dimuthu Perera, Marina Konopleva, Steven M. Kornblau, Joseph D. Khoury, Warren Fiskus, Tianyu Cai, Naveen Pemmaraju
Publikováno v:
Blood Cancer Journal
Blood Cancer Journal, Vol 9, Iss 2, Pp 1-13 (2019)
Blood Cancer Journal, Vol 9, Iss 2, Pp 1-13 (2019)
First-generation bromodomain extra-terminal protein (BETP) inhibitors (BETi) (e.g., OTX015) that disrupt binding of BETP BRD4 to chromatin transcriptionally attenuate AML-relevant progrowth and prosurvival oncoproteins. BETi treatment induces apoptos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e24a129a36d61546d9de9f358320ee7
https://doi.org/10.1038/s41408-018-0165-5
https://doi.org/10.1038/s41408-018-0165-5
Autor:
Srdan Verstovsek, Steve Horrigan, Christopher P. Mill, Sunil Sharma, Steven M. Kornblau, Craig M. Crews, Taghi Manshouri, Baohua Sun, Kapil N. Bhalla, Prithviraj Bose, Agnieszka J Nowak, Tapan M. Kadia, Peng Qiu, Kimal Rajapakshe, Raffaella Soldi, David N. Saenz, Gautam Borthakur, Warren Fiskus, Dyana T. Saenz, Kanak Raina, Cristian Coarfa, Lucia Masarova, Joseph D. Khoury, Yimin Qian
Publikováno v:
Leukemia. 33(6)
Transformation of post-myeloproliferative neoplasms into secondary (s) AML exhibit poor clinical outcome. In addition to increased JAK-STAT and PI3K-AKT signaling, post-MPN sAML blast progenitor cells (BPCs) demonstrate increased nuclear β-catenin l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c056297cceeee15fce9aa3e9c09917
https://pubmed.ncbi.nlm.nih.gov/30575820
https://pubmed.ncbi.nlm.nih.gov/30575820
Autor:
Yu Shen, Dyana T. Saenz, Thurika Ganesh, David N. Saenz, Gautam Borthakur, Kapil N. Bhalla, Vaishnavi Rao, Christopher P. Mill, Joseph D. Khoury, Steven M. Kornblau, Wendy Jin, Warren Fiskus, Marina Konopleva, Courtney D. DiNardo, Baohua Sun, Agnieszka J Nowak, Tianyu Cai, Tapan M. Kadia
Publikováno v:
Blood. 132:1351-1351
Bromodomain extra-terminal (BET) protein (BETP) family of chromatin reader proteins includes BRD4 that binds to acetylated lysine in the active chromatin and transcription factors (TFs) at enhancers and promoters, as well as increases RNA pol II (RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa48495a28a86e5044331fc345d3e512
https://doi.org/10.1182/blood-2018-99-113976
https://doi.org/10.1182/blood-2018-99-113976
Autor:
Sunil Sharma, Joseph D. Khoury, Gautam Borthakur, Kapil N. Bhalla, Christopher P. Mill, Courtney D. DiNardo, Roulan Han, Vaishnavi Rao, Wendy Jin, Tapan M. Kadia, David N. Saenz, Dyana T. Saenz, Thurika Ganesh, Warren Fiskus, Raffaella Soldi, Baohua Sun, Agnieszka J Nowak
Publikováno v:
Blood. 132:3930-3930
There is a clear need to develop novel therapies that would overcome differentiation block and eliminate AML stem/progenitor cells. Genetic and epigenetic dysregulation of enhancers regulates expressions of myeloid lineage transcriptional regulators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04512d4392002900852a30cba74a688e
https://doi.org/10.1182/blood-2018-99-114198
https://doi.org/10.1182/blood-2018-99-114198
Autor:
David N. Saenz, Christopher P. Mill, Warren Fiskus, Dyana T. Saenz, Steven M. Kornblau, Kapil N. Bhalla, Baohua Sun, Agnieszka J Nowak, Courtney D. DiNardo
Publikováno v:
Cancer Research. 78:3884-3884
RUNX1 is a master-regulator transcription factor involved in normal and malignant hematopoiesis. In addition to chromosomal translocations involving the RUNX1 locus, somatic, heterozygous RUNX1 mutations commonly occur in MDS, CMML, as well as in sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3f0bfd99750b59c6cc35bd8dce7c637
https://doi.org/10.1158/1538-7445.am2018-3884
https://doi.org/10.1158/1538-7445.am2018-3884
Autor:
Kapil Bhalla, Steven M. Kornblau, Sunil Sharma, David N. Saenz, Christopher P. Mill, Baohua Sun, Dyana T. Saenz, Agnieszka J Nowak, Warren Fiskus
Publikováno v:
Cancer Research. 78:802-802
KDM1A is an FAD-dependent amine oxidase that demethylates H3K4Me1/2 chromatin, which regulates enhancer maintenance and transcription in stem/progenitor cells. GFI1 is a zinc-finger transcriptional repressor that binds and recruits KDM1A-CoREST-HDAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f6c141edf4e7485a0394ee527861a38
https://doi.org/10.1158/1538-7445.am2018-802
https://doi.org/10.1158/1538-7445.am2018-802