Výsledky vyhledávání - "David N. Orth"

The effect of feeding on cerebrospinal fluid corticotropin-releasing hormone levels in humans

Autor: Dewleen G. Baker, Mary M. Hagan, Nosakhare N. Ekhator, Peter T. Loosen, Thomas D. Geracioti, Wendell E. Nicholson, David N. Orth, Jeffrey R. Strawn, John Kasckow, J.J. Mulchahey

Publikováno v: Brain Research. 904:218-224

Corticotropin-releasing hormone (CRH) is a neuropeptide thought to play a role in appetite regulation. In this report, we used a serial cerebrospinal fluid (CSF) sampling technique to examine the relationship between CSF CRH, plasma ACTH and cortisol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f13fd84e2269fd67e8a55dd107cd58
https://doi.org/10.1016/s0006-8993(01)02461-1

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Serial CSF Corticotropin-Releasing Hormone Levels and Adrenocortical Activity in Combat Veterans With Posttraumatic Stress Disorder

Autor: Nosa N. Ekhator, Wendall E. Nicholson, Dewleen G. Baker, John Kasckow, Thomas D. Geracioti, Scott A. West, Ann B. Bruce, David N. Orth, Kelly K. Hill

Publikováno v: American Journal of Psychiatry. 156:585-588

The authors sought to carefully test, by using a technique of continuous CSF sampling, the hypothesis that basal elevations in CSF corticotropin-releasing hormone (CRH) concentrations exist in patients with posttraumatic stress disorder (PTSD). They

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a194be1d3f8f21f8049d863da62e26
https://doi.org/10.1176/ajp.156.4.585

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Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid

Autor: Stephan Arndt, Peter T. Loosen, E B S Wendell Nicholson, Nosa N. Ekhator, David N. Orth, Thomas D. Geracioti

Publikováno v: Depression and Anxiety. 10:77-80

Despite strong evidence of a physiologic relationship between cholecystokinin (CCK) and corticotropin-releasing hormone (CRH) in the rat central nervous system (CNS), evidence of such a relationship between the two hormones in the human CNS is lackin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5086d7002e127914e0eae1f0241eb431
https://doi.org/10.1002/(sici)1520-6394(1999)10:2<77::aid-da7>3.0.co

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Low cerebrospinal fluid corticotropin-releasing hormone concentrations in eucortisolemic depression

Autor: Thomas D. Geracioti, Peter T. Loosen, David N. Orth

Publikováno v: Biological Psychiatry. 42:165-174

Hypersecretion of corticotropin-releasing hormone (CRH) and resulting hypercortisolism have been implicated in the pathogenesis of major depression. To test this CRH hypersecretion hypothesis, cerebrospinal fluid (CSF) was continuously withdrawn from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c067d68fe4a30387bb32465ad03c12
https://doi.org/10.1016/s0006-3223(96)00312-5

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Preprothyrotropin-releasing hormone-(178-199) does not inhibit corticotropin release

Autor: David N. Orth, Wendell E. Nicholson

Publikováno v: Endocrinology. 137:2171-2174

Pituitary ACTH synthesis and secretion are positively regulated by hypothalamic factors and negatively regulated by adrenal corticosteroids. Negative hypothalamic regulation of pituitary ACTH synthesis and secretion has been postulated, but not prove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ace7c059e571b3662c16139d828d675
https://doi.org/10.1210/endo.137.5.8612564

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Role of lipoxygenase metabolites of arachidonic acid in the regulation of adrenocorticotropin secretion by perifused rat anterior pituitary cells

Autor: Justin G. S. Won, David N. Orth

Publikováno v: Endocrinology. 135:1496-1503

Arachidonic acid metabolites have been implicated in the regulation of ACTH secretion. To define further which eicosanoid(s) is primarily involved, we examined the effects of both inhibitors of the three arachidonate metabolic pathways (cyclooxygenas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432cdb3ad85052b6ef95b16ac56ae017
https://doi.org/10.1210/endo.135.4.7523100

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Multiple Recurrent Carcinoid Tumors That Secreted Adrenocorticotropin (ACTH) Over a Period of 26 Years

Autor: David N. Orth, Thomas B. Connor, Julia-Betts Williams, Colin Wood, Barry K. Lance

Publikováno v: The Endocrinologist. 4:177-183

We report a patient who first developed ACTH-dependent Cushing's syndrome in early 1963 and, because the source of ACTH could not be found, was adrenalectomized in September 1963. He thed suddenly in 1989 at age 70, after suffering brief chest pain.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97138dfa3ddc2e6e15b86c95497ded1f
https://doi.org/10.1097/00019616-199405000-00005

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Concentrations of Corticotropin-Releasing Hormone, Norepinephrine, MHPG, 5-Hydroxyindoleacetic Acid, and Tryptophan in the Cerebrospinal Fluid of Alcoholic Patients: Serial Sampling Studies

Autor: Peter T. Loosen, David N. Orth, Thomas D. Geracioti, Nosa N. Ekhator, Michael H. Ebert, Wendell E. Nicholson, Donna Burns

Publikováno v: Neuroendocrinology. 60:635-642

Abnormalities in corticotropin-releasing hormone (CRH) secretion, noradrenergic neurotransmission, and serotonergic activity in the central nervous system (CNS) have all been hypothesized to exist in alcoholic patients, as have abnormalities in hypot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d56ca316655598dbb07881c9d2ccfaa
https://doi.org/10.1159/000126807

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