Zobrazeno 1 - 10
of 80
pro vyhledávání: '"David N. Garboczi"'
Autor:
Nicholas J. MacDonald, Kavita Singh, Karine Reiter, Vu Nguyen, Richard Shimp, Apostolos G. Gittis, Beth Chen, Martin Burkhardt, Baoshan Zhang, Zhixiong Wang, Raul Herrera, Mackenzie Moler, Duck-Yeon Lee, Sachy Orr-Gonzalez, Jessica Herrod, Lynn E. Lambert, Kelly M. Rausch, Olga Muratova, David S. Jones, Yimin Wu, Albert J. Jin, David N. Garboczi, Patrick E. Duffy, David L. Narum
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Development of a malaria vaccine that blocks transmission of different parasite stages to humans and mosquitoes is considered critical for elimination efforts. A vaccine using Pfs25, a protein on the surface of zygotes and ookinetes, is unde
Externí odkaz:
https://doaj.org/article/744dd43cb85546b1a8f8ee76086ef8c5
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The S9.6 monoclonal antibody is widely used to map R-loops genome wide. Here, Bou-Nader et al., define the nucleic acid-binding specificity of S9.6 and report its crystal structures free and bound to a hybrid, which reveal the asymmetric recognition
Externí odkaz:
https://doaj.org/article/72b7f5732f7c4a07a879fd125d37cd1f
Autor:
Olivia Kern, Paola Carolina Valenzuela Leon, Apostolos G. Gittis, Brian Bonilla, Phillip Cruz, Andrezza Campos Chagas, Sundar Ganesan, Jose M.C. Ribeiro, David N. Garboczi, Ines Martin-Martin, Eric Calvo
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 95-105 (2021)
Female mosquitoes require blood meals for egg development. The saliva of blood feeding arthropods contains biochemically active molecules, whose anti-hemostatic and anti-inflammatory properties facilitate blood feeding on vertebrate hosts. While tran
Externí odkaz:
https://doaj.org/article/ebbe72364e61453cb6fb1c06a9f81770
Autor:
Ines Martin-Martin, Andrew Paige, Paola Carolina Valenzuela Leon, Apostolos G. Gittis, Olivia Kern, Brian Bonilla, Andrezza Campos Chagas, Sundar Ganesan, Leticia Barion Smith, David N. Garboczi, Eric Calvo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
D7 proteins are highly abundant in the salivary glands of several blood feeding insects. Here, the authors study the ligand binding specificity and physiological roles of the mosquito D7 proteins CxD7L1 and CxD7L2, showing that CxD7L1 acquired ADP-bi
Externí odkaz:
https://doaj.org/article/dada7b2dad22487ba29eabdf46abee8b
Autor:
David N. Garboczi, Andrezza C. Chagas, Paola Carolina Valenzuela Leon, Eric Calvo, Ines Martin-Martin, Phillip Cruz, José M. C. Ribeiro, Apostolos G. Gittis, Brian Bonilla, Olivia Kern, Sundar Ganesan
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss, Pp 95-105 (2021)
Female mosquitoes require blood meals for egg development. The saliva of blood feeding arthropods contains biochemically active molecules, whose anti-hemostatic and anti-inflammatory properties facilitate blood feeding on vertebrate hosts. While tran
Autor:
Karine Reiter, Daniel Veltri, Raul Herrera, Baoshan Zhang, Vu Nguyen, David L. Narum, Sofia Nakuchima, David N. Garboczi, Bruce J. Swihart, Martin Burkhardt, Emily Kelnhofer, Apostolos G. Gittis, Patrick E. Duffy, Olga Muratova, Nicholas J. MacDonald, Richard L. Shimp, Kavita Singh, Margery G. Smelkinson
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology
Communications Biology
Proteins Pfs230 and Pfs48/45 are Plasmodium falciparum transmission-blocking (TB) vaccine candidates that form a membrane-bound protein complex on gametes. The biological role of Pfs230 or the Pfs230-Pfs48/45 complex remains poorly understood. Here,
Publikováno v:
Nature communications. 13(1)
R-loops are ubiquitous, dynamic nucleic-acid structures that play fundamental roles in DNA replication and repair, chromatin and transcription regulation, as well as telomere maintenance. The DNA-RNA hybrid–specific S9.6 monoclonal antibody is wide
Autor:
Patricia H. Alvarenga, Denis R. Dias, Xueqing Xu, Ivo M.B. Francischetti, Apostolos G. Gittis, Gabriela Arp, David N. Garboczi, José M.C. Ribeiro, John F. Andersen
Publikováno v:
Insect Biochem Mol Biol
The D7 proteins are highly expressed in the saliva of hematophagous Nematocera and bind biogenic amines and eicosanoid compounds produced by the host during blood feeding. These proteins are encoded by gene clusters expressing forms having one or two
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
The poxvirus F9 protein is a component of the vaccinia virus entry fusion complex (EFC) which consists of 11 proteins. The EFC forms a unique apparatus among viral fusion proteins and complexes. We solved the atomic structure of the F9 ectodomain at
Autor:
Olivia, Kern, Paola Carolina, Valenzuela Leon, Apostolos G, Gittis, Brian, Bonilla, Phillip, Cruz, Andrezza Campos, Chagas, Sundar, Ganesan, Jose M C, Ribeiro, David N, Garboczi, Ines, Martin-Martin, Eric, Calvo
Publikováno v:
Current Research in Structural Biology
Female mosquitoes require blood meals for egg development. The saliva of blood feeding arthropods contains biochemically active molecules, whose anti-hemostatic and anti-inflammatory properties facilitate blood feeding on vertebrate hosts. While tran