Zobrazeno 1 - 3
of 3
pro vyhledávání: '"David N. Fiflis"'
Autor:
David N. Fiflis, Nicolas A. Rey, Harshitha Venugopal-Lavanya, Beatrice Sewell, Aaron Mitchell-Dick, Katie N. Clements, Sydney Milo, Abigail R. Benkert, Alan Rosales, Sophia Fergione, Aravind Asokan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Type VI CRISPR enzymes have been developed as programmable RNA-guided Cas proteins for eukaryotic RNA editing. Notably, Cas13 has been utilized for site-targeted single base edits, demethylation, RNA cleavage or knockdown and alternative spl
Externí odkaz:
https://doaj.org/article/4a9e799fbf1b4f619012e055594df9cf
Autor:
Ezra J. Loeb, Patrick L. Havlik, Zachary C. Elmore, Alan Rosales, Sophia M. Fergione, Trevor J. Gonzalez, Timothy J. Smith, Abigail R. Benkert, David N. Fiflis, Aravind Asokan
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113902- (2024)
Summary: Adeno-associated virus (AAV) is a member of the genus Dependoparvovirus, which infects a wide range of vertebrate species. Here, we observe that, unlike most primate AAV isolates, avian AAV is transcriptionally silenced in human cells. By sw
Externí odkaz:
https://doaj.org/article/80e360eb884e4f9ebe6cb54049ee9c77
Autor:
Anshuman Das, Madhuvanthi Vijayan, Eric M. Walton, V. Grace Stafford, David N. Fiflis, Aravind Asokan
Publikováno v:
Journal of virology. 96(4)
The single-stranded DNA genome of adeno-associated viruses (AAV) undergoes second-strand synthesis and transcription in the host cell nucleus. While wild-type AAV genomes are naturally silenced upon integration into the host genome, recombinant AAV (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514ca69bcda8d165fdd2e556cae523cd
https://pubmed.ncbi.nlm.nih.gov/34878926
https://pubmed.ncbi.nlm.nih.gov/34878926