Zobrazeno 1 - 10
of 30
pro vyhledávání: '"David N. Douda"'
Autor:
Meraj A. Khan, Armin Farahvash, David N. Douda, Johann-Christoph Licht, Hartmut Grasemann, Neil Sweezey, Nades Palaniyar
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Neutrophils cast neutrophil extracellular traps (NETs) to ensnare microbial pathogens. Nevertheless, the molecular rheostats that regulate NETosis in response to bacteria are not clearly established. We hypothesized that stress-activated pro
Externí odkaz:
https://doaj.org/article/2755d4df15b743fba2daff2f45656a21
Autor:
Joshua eYuen, Fred G. Pluthero, David N. Douda, Magdalena eRiedl, Ahmed eCherry, Marina eUlanova, Walter H.A. Kahr, Nades ePalaniyar, Christoph eLicht
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Neutrophils deposit antimicrobial proteins such as myeloperoxidase and proteases on chromatin, which they release as neutrophil extracellular traps (NETs). Neutrophils also carry key components of the complement alternative pathway (AP) such as prope
Externí odkaz:
https://doaj.org/article/7bea660d8dc941dcb3885490050d0e3e
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Pulmonary exacerbations in cystic fibrosis airways are accompanied by inflammation, neutrophilia, and mucous thickening. Cystic fibrosis sputum contains a large amount of uncleared DNA contributed by neutrophil extracellular trap (NET) formation from
Externí odkaz:
https://doaj.org/article/93e298e90b1c4148bd88b301c75e5f96
Autor:
Madonna R. Peter, Mirjana Jerkic, Valentin Sotov, David N. Douda, Daniela S. Ardelean, Niousha Ghamami, Flavia Lakschevitz, Meraj A. Khan, Susan J. Robertson, Michael Glogauer, Dana J. Philpott, Nades Palaniyar, Michelle Letarte
Publikováno v:
Mediators of Inflammation, Vol 2014 (2014)
Endoglin is a coreceptor of the TGF-β superfamily predominantly expressed on the vascular endothelium and selective subsets of immune cells. We previously demonstrated that Endoglin heterozygous (Eng+/−) mice subjected to dextran sulfate sodium (D
Externí odkaz:
https://doaj.org/article/344bf2cbeff046c28e604eb1f699f0e3
Autor:
Lisa Newhook, Purva P. Bhojane, Peter W. Repenning, Diego Perez Escanda, Nichole K. Escalante, Patricia Zwierzchowski, Alec Robinson, Lauren Clifford, Harsh Pratap, David N. Douda, Chayne L. Piscitelli, Nicole J. Afacan, Thomas Spreter von Kreudenstein, Nina E. Weisser
Publikováno v:
Cancer Research. 83:5121-5121
Bispecific T cell engager (TCE) therapies have exhibited clinical utility against hematological cancers, but limited success in solid tumors. Treatment of solid tumors has additional challenges - including immunosuppressive environments and low T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce0b30ab0d4c4263c81cb50f1010c356
https://doi.org/10.1158/1538-7445.am2023-5121
https://doi.org/10.1158/1538-7445.am2023-5121
Autor:
Charles N. Serhan, Jennifer K. Colby, Katherine H. Walker, Ho Pan Sham, Bruce D. Levy, Nandini Krishnamoorthy, David N. Douda, Raja-Elie E. Abdulnour, Ioanna Barkas, Sarah Benito-Figueroa, Paul C. Norris
Publikováno v:
The Journal of Immunology. 200:2757-2766
Specialized proresolving mediators (SPMs) decrease NF-κB activity to prevent excessive tissue damage and promote the resolution of acute inflammation. Mechanisms for NF-κB regulation by SPMs remain to be determined. In this study, after LPS challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d77d4907c589ca147aea8158a9b794ef
https://doi.org/10.4049/jimmunol.1602090
https://doi.org/10.4049/jimmunol.1602090
Autor:
Nizar N. Jarjour, Serpil C. Erzurum, Raja-Elie E. Abdulnour, Xiao Wang, Isabell Ricklefs, David T. Mauger, David N. Douda, Melody G. Duvall, Daniel Irimia, Bruce D. Levy, Luciana P. Tavares, Mario Castro, Sally E. Wenzel, Denisa D. Wagner, Benjamin Gaston, Eugene R. Bleecker, Nandini Krishnamoorthy, John V. Fahy, Thayse Regina Brüggemann, Elliot Israel, Kimberly Martinod, Manuela Cernadas, Eleanor M. Dunican
Publikováno v:
Science Immunology. 3
Severe asthma is a debilitating and treatment refractory disease. As many as half of these patients have complex neutrophil-predominant lung inflammation that is distinct from milder asthma with type 2 eosinophilic inflammation. New insights into sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0319a3d4ab0ad0300da2160c15fe1d5b
https://doi.org/10.1126/sciimmunol.aao4747
https://doi.org/10.1126/sciimmunol.aao4747
Autor:
Nandini, Krishnamoorthy, David N, Douda, Thayse R, Brüggemann, Isabell, Ricklefs, Melody G, Duvall, Raja-Elie E, Abdulnour, Kimberly, Martinod, Luciana, Tavares, Xiao, Wang, Manuela, Cernadas, Elliot, Israel, David T, Mauger, Eugene R, Bleecker, Mario, Castro, Serpil C, Erzurum, Benjamin M, Gaston, Nizar N, Jarjour, Sally, Wenzel, Eleanor, Dunican, John V, Fahy, Daniel, Irimia, Denisa D, Wagner, Bruce D, Levy
Publikováno v:
Science immunology. 3(26)
Severe asthma is a debilitating and treatment refractory disease. As many as half of these patients have complex neutrophil-predominant lung inflammation that is distinct from milder asthma with type 2 eosinophilic inflammation. New insights into sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8f7e97c1f481dfdcafe0408b67cd8b2
https://pubmed.ncbi.nlm.nih.gov/30143797
https://pubmed.ncbi.nlm.nih.gov/30143797
Autor:
Rebecca M. Baron, Taylor E. Miller, David N. Douda, Julian Gomez-Cambronero, Alexander H. Tavares, Bruce D. Levy, Judie A. Howrylak, Raja-Elie E. Abdulnour, Karen M. Henkels, Laura E. Fredenburgh
Publikováno v:
Journal of leukocyte biology. 103(5)
Phospholipase D (PLD) plays important roles in cellular responses to tissue injury that are critical to acute inflammatory diseases, such as the acute respiratory distress syndrome (ARDS). We investigated the expression of PLD isoforms and related ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb6989d5ba9a15dbca2b8c7bf01b3e9
https://pubmed.ncbi.nlm.nih.gov/29437245
https://pubmed.ncbi.nlm.nih.gov/29437245
Autor:
Hartmut Grasemann, Meraj A. Khan, Neil B. Sweezey, Johann-Christoph Licht, David N. Douda, Armin Farahvash, Nades Palaniyar
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Neutrophils cast neutrophil extracellular traps (NETs) to ensnare microbial pathogens. Nevertheless, the molecular rheostats that regulate NETosis in response to bacteria are not clearly established. We hypothesized that stress-activated protein kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6a2c607ff10b9197d58bd306bfb2d2
https://doi.org/10.1038/s41598-017-03257-z
https://doi.org/10.1038/s41598-017-03257-z