Zobrazeno 1 - 4
of 4
pro vyhledávání: '"David N. A. Mekhaiel"'
Autor:
David N. A. Mekhaiel, Paul G. Hitchen, Stuart M. Haslam, Anne Dell, Maria Panico, Richard J. Pleass, Howard R. Morris, Jane E. Hewitt, Rebecca Harrison
Publikováno v:
Glycobiology. 22:662-675
α-Dystroglycan (DG) is a key component of the dystrophin-glycoprotein complex. Aberrant glycosylation of the protein has been linked to various forms of congenital muscular dystrophy. Unusually α-DG has previously been demonstrated to be modified w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9406e4d3e3016f7a3576076630785f
https://doi.org/10.1093/glycob/cws002
https://doi.org/10.1093/glycob/cws002
Publikováno v:
Trends in Parasitology. 27:523-529
The 'hygiene hypothesis', or lack of microbial and parasite exposure during early life, is postulated as an explanation for the recent increase in autoimmune and allergic diseases in developed countries. The favored mechanism is that microbial and pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec597805dc09b65bfa12e89968a35fc4
https://doi.org/10.1016/j.pt.2011.08.003
https://doi.org/10.1016/j.pt.2011.08.003
Autor:
Zhifeng Shao, Gang Wu, Daniel M. Czajkowsky, David N. A. Mekhaiel, Shona C Moore, Stuart M. Haslam, Richard J. Pleass, Marco Colonna, Jianfeng He, Inger Sandlie, Anja Fuchs, Patricia A. Blundell, Anne Dell, Daniel A. Mitchell, Tim Wilson, Katy A. Lloyd, Jan Terje Andersen
Publikováno v:
Scientific Reports
The remarkable clinical success of Fc-fusion proteins has driven intense investigation for even more potent replacements. Using quality-by-design (QbD) approaches, we generated hexameric-Fc (hexa-Fc), a ~20 nm oligomeric Fc-based scaffold that we her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06e24677e5bbb787291379379c0537a
http://europepmc.org/articles/PMC5224519
http://europepmc.org/articles/PMC5224519
Autor:
Jianfeng He, Zhifeng Shao, Jun Hu, Marwa H. El-Faham, Jianguo Shi, Richard J. Pleass, Michael J. Doenhoff, Jan Terje Andersen, Inger Sandlie, David N. A. Mekhaiel, Daniel M. Czajkowsky, Richard S. McIntosh
Publikováno v:
Scientific Reports
The success of Fc-fusion bio-therapeutics has spurred the development of other Fc-fusion products for treating and/or vaccinating against a range of diseases. We describe a method to modulate their function by converting them into well-defined stable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e2302eb8b96166c2e5d6d42b654aa1
http://hdl.handle.net/10852/54164
http://hdl.handle.net/10852/54164
