The creation and characterisation of a National Compound Collection:the Royal Society of Chemistry pilot

Autor: David M. Andrews, Richard Kidd, Paul J. Edwards, Stephen L. Garland, David N. A. Fox, Timothy Gallagher, Laura M. Broad, Joseph B. Sweeney

Publikováno v: Andrews, D, Broad, L M, Edwards, P, Fox, D, Gallagher, T, Garland, S, Kidd, R & Sweeney, J 2016, ' The creation and characterisation of a National Compound Collection : the Royal Society of Chemistry pilot ', Chemical Science, vol. 7, no. 6, pp. 3869-3878 . https://doi.org/10.1039/C6SC00264A
Chemical Science

We report the extraction of compound data from historical literature, making it chemically searchable. Evaluation by drug discovery groups reveals the utility of this approach.
We present a summary of the National Compound Collection (NCC) pilot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7674c4943bd870faaca550bf86a35a
https://research-information.bris.ac.uk/en/publications/dea9b0b3-6d2c-4a09-8df6-741d443a7fe4

ChemInform Abstract: Enantioselective Synthesis of Pumiliotoxin 251D. A Strategy Employing an Allene-Based Electrophile-Mediated Cyclization

Autor: David N. A. Fox, Mary F. Mahon, David Lathbury, Kieran C. Molloy, Timothy Gallagher

Publikováno v: ChemInform. 22

The enantioselective synthesis of pumiliotoxin 251D (1) (nine steps, 6.3% overall yield) is described in which the Pd II -mediated cyclization of the optically pure allenic amine 6 to give pyrrolidine 7a plays a central role. The functionality that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e187feaf21d660106111d18a3d13890
https://doi.org/10.1002/chin.199129270

ChemInform Abstract: Cationic Mono- and Bi-Nuclear Iron Complexes as Lewis Acid Catalysts in Mukaiyama Reactions

Autor: David N. A. Fox, Thorsten Bach, Manfred T. Reetz

Publikováno v: ChemInform. 24

Organometallic Lewis acids derived from photolysis of mono- and bi-nuclear cationic iron carbonyl complexes function as excellent catalysts for the Mukaiyama aldol reaction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae09a07968a89ae8a0fcf56184684531
https://doi.org/10.1002/chin.199307087

A rapid injection NMR study of the chelation controlled Mukaiyama aldol addition: TiCl4 versus LiClO4 as the Lewis acid

Autor: Charles F. Marth, Helmut M. Hügel, Manfred T. Reetz, Burkhard Raguse, Thorsten Bach, David N. A. Fox

Publikováno v: Tetrahedron. 48:5731-5742

The concept of chelation controlled addition to chiral alkoxy aldehydes using Lewis acids and mild C-nucleophiles has been extended to include cyclopropylation. The mechanism of the TiCl4-mediated chelation controlled addition of enolsilanes and ally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90f927acf55056a7e0c2aeeb3938bcda
https://doi.org/10.1016/0040-4020(92)80024-a

Asymmetric synthesis via electrophile-mediated cyclisations

Autor: Timothy Gallagher, David N. A. Fox

Publikováno v: Tetrahedron. 46:4697-4710

The electrophile-mediated cyclisation of a series of allenic amines (8a-e), carrying a chiral benzylic residue on nitrogen, has been examined using Ag(I) and Pd(II). The cyclised products, (9/10)(using Ag(I)) and (12/13)(using Pd(II), CO, MeOH), are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f373f0c9191cd2d92c7a9b7fa4e28384
https://doi.org/10.1016/s0040-4020(01)85590-3