Zobrazeno 1 - 6
of 6
pro vyhledávání: '"David N Harrison"'
Autor:
Hannah A D King, Chan-Sien Lay, Heidi E. Drummer, Vani G.S. Narasimhulu, Annamarie E. Laumaea, Anna Kathryn Bellamy-McIntyre, Pantelis Poumbourios, David N Harrison
Publikováno v:
Journal of Biological Chemistry. 293:6099-6120
HIV-1 is spread by cell-free virions and by cell-cell viral transfer. We asked whether the structure and function of a broad neutralizing antibody (bNAb) epitope, the membrane-proximal ectodomain region (MPER) of the viral gp41 transmembrane glycopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e55ce413a2a87ec0f2b1649ddbd405e
https://doi.org/10.1074/jbc.ra117.000537
https://doi.org/10.1074/jbc.ra117.000537
Autor:
Jessica K. Holien, Craig E. Cameron, Steven Petrou, David N. Harrison, Jamie J. Arnold, Eric D. Smidansky, Elena V. Gazina, Brett A. Cromer, Michael W. Parker
Publikováno v:
Journal of Virology. 85:10364-10374
Amiloride and its derivative 5-( N -ethyl- N -isopropyl)amiloride (EIPA) were previously shown to inhibit coxsackievirus B3 (CVB3) RNA replication in cell culture, with two amino acid substitutions in the viral RNA-dependent RNA polymerase 3D pol con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25458ce5e98d7df0552d8d43ca26bd31
https://doi.org/10.1128/jvi.05022-11
https://doi.org/10.1128/jvi.05022-11
Publikováno v:
Journal of Virology
Amiloride derivatives are known blockers of the cellular Na + /H + exchanger and the epithelial Na + channel. More recent studies demonstrate that they also inhibit ion channels formed by a number of viral proteins. We previously reported that 5-( N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3124521109b91f6af4a1c96ea16ce33f
Autor:
Stirling John Edwards, Fasséli Coulibaly, Heidi E. Drummer, Yousef M O Alhammad, Patricia Vietheer, Kathleen McCaffrey, Charles Quinn, David N Harrison, Pantelis Poumbourios, Jun Gu, S F Irene Boo
Publikováno v:
Journal of Virology
Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a heterodimer and mediate receptor interactions and viral fusion. Both E1 and E2 are targets of the neutralizing antibody (NAb) response and are candidates for the production of vaccines t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428bd9d612fb439c6391cac950b5d44d
https://pubmed.ncbi.nlm.nih.gov/26378182
https://pubmed.ncbi.nlm.nih.gov/26378182
Autor:
Heneu Tan, Meryem Jefferies, David A. Anderson, Steven Petrou, Elena V. Gazina, David N. Harrison, David A. Williams
Publikováno v:
Antiviral Research. 67:98-106
Picornavirus replication causes leakage of cytoplasmic K+ and an influx of Na+ and Ca2+. In this study, we have explored the possibility that a blockade of Ca2+ and Na+ influx would reduce rhinovirus production and/or release. The Ca2+-channel blocke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1334c5a921e2f201f3ae135f5fb4b01b
https://doi.org/10.1016/j.antiviral.2005.05.003
https://doi.org/10.1016/j.antiviral.2005.05.003
Autor:
Pantelis Poumbourios, Ashraf I Khasawneh, Annemarie Laumaea, Heidi E. Drummer, Anna Kathryn Bellamy-McIntyre, David N Harrison
Publikováno v:
Retrovirology
Background The disulfide-bonded region (DSR) of HIV-1 gp41 mediates association with gp120 and plays a role in transmission of receptor-induced conformational changes in gp120 to gp41 that activate membrane fusion function. In this study, forced vira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45c4903d791d3b04ae059363e32a6e6
https://pubmed.ncbi.nlm.nih.gov/23618462
https://pubmed.ncbi.nlm.nih.gov/23618462